Patents by Inventor Kyouji Doi

Kyouji Doi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9746555
    Abstract: The planar antenna has a dielectric substrate; an antenna main body portion including first and second antenna elements on first and second sides, respectively, of the dielectric substrate and functioning as a balanced antenna; a signal line portion including first and second feed lines on the first and second sides, respectively, and a coplanar line on the first side and formed by a signal line and the first ground conductors, the signal line connected to the first feed line; a second ground conductor on the second side and connected to the second feed line; and via holes connecting the first ground conductors to the second ground conductor provided at ends of edges of the first ground conductors facing the end of the signal line where the signal line connects to the first feed line, to allow the first and second feed lines to function as balanced transmission lines.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: August 29, 2017
    Assignee: MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Yasunari Mori, Kyouji Doi, Takayoshi Yumii, Yumi Asano
  • Patent number: 9291563
    Abstract: FRET measurement uses a FRET probe that includes a probe element X containing a donor fluorescent substance and a probe element Y containing an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. The modulation frequency of laser light with which the FRET probe is irradiated is adjusted to an optimum modulation frequency that maximizes a difference between the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET occurs and the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET does not occur.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 22, 2016
    Assignees: MITSUI ENGINEERING & SHIPBUILDING, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shigeyuki Nakada, Yusuke Ohba, Kyouji Doi, Yumi Asano
  • Publication number: 20150130659
    Abstract: The planar antenna has a dielectric substrate; an antenna main body portion including first and second antenna elements on first and second sides, respectively, of the dielectric substrate and functioning as a balanced antenna; a signal line portion including first and second feed lines on the first and second sides, respectively, and a coplanar line on the first side and formed by a signal line and the first ground conductors, the signal line connected to the first feed line; a second ground conductor on the second side and connected to the second feed line; and via holes connecting the first ground conductors to the second ground conductor provided at ends of edges of the first ground conductors facing the end of the signal line where the signal line connects to the first feed line, to allow the first and second feed lines to function as balanced transmission lines.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 14, 2015
    Inventors: Yasunari MORI, Kyouji DOI, Takayoshi YUMII, Yumi ASANO
  • Publication number: 20150044690
    Abstract: FRET measurement uses a FRET probe that includes a probe element X containing a donor fluorescent substance and a probe element Y containing an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. The modulation frequency of laser light with which the FRET probe is irradiated is adjusted to an optimum modulation frequency that maximizes a difference between the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET occurs and the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET does not occur.
    Type: Application
    Filed: March 22, 2013
    Publication date: February 12, 2015
    Applicants: Mitsui Engineering & Shipbuilding Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shigeyuki Nakada, Yusuke Ohba, Kyouji Doi, Yumi Asano
  • Publication number: 20150044763
    Abstract: FRET measurement uses a FRET probe that includes a probe element X labeled with a donor fluorescent substance and a probe element Y labeled with an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. A test sample as a measuring object in FRET measurement contains a test object about which it is unknown whether or not it has an approaching/binding property of allowing the probe element X and the probe element Y to approach to each other or bind together or a separating property of separating from each other the probe element X and the probe element Y that are in a state where they adjoin each other or bind together. A plurality of sets of a fluorescence lifetime ?sample and a ratiometry Rsample obtained by this measurement are used to judge whether or not the test object has the approaching/binding property or the separating property.
    Type: Application
    Filed: March 22, 2013
    Publication date: February 12, 2015
    Applicants: Mitsui Engineering & Shipbuilding Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shigeyuki Nakada, Yusuke Ohba, Kyouji Doi, Yumi Asano
  • Patent number: 8772739
    Abstract: A fluorescence detection device generates a modulation signal for modulating the intensity of the laser light and modulates the laser light using the modulation signal. The detection device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light, and calculates, from the fluorescent signal, a fluorescence intensity and the phase delay of the fluorescence with respect to the modulation signal. At the time, the detection device controls the operation amounts of the signal level of a DC component of the modulation signal and the gain of amplification just after the output of the fluorescent signal so that the value of a fluorescence intensity signal falls within a preset range. After the operation amounts are settled, the detection device calculates the fluorescence intensity and then calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object using the phase delay.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: July 8, 2014
    Assignee: Mitsui Engineering & Shipbuilding Co., Ltd.
    Inventors: Shigeyuki Nakada, Kyouji Doi
  • Patent number: 8642976
    Abstract: A fluorescence detecting device generates a modulation signal for modulating an intensity of laser light and modulates the laser light by using the modulation signal, when receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit. The fluorescence detecting device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light and calculates, from the fluorescent signal, the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detecting device controls the frequency of the modulation signal so that the value of the phase delay comes close to a preset value. The fluorescence detecting device calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object by using a phase delay obtained under the condition of frequency of the modulation signal at the time when the control is settled.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: February 4, 2014
    Assignee: Mitsui Engineering & Shipbuilding Co., Ltd.
    Inventors: Shigeyuki Nakada, Kyouji Doi
  • Patent number: 8415627
    Abstract: Fluorescence detection device employed in a flow site meter emits laser light intensity-modulated by a modulation signal and acquires the fluorescence signal of fluorescence emitted from a measurement object passing through a measurement point of the laser light. The device generates the reference signal, separately from the modulation signal, the reference signal having a frequency different from the frequency of the modulation signal and having a phase synchronized with a phase of the modulation. The device determines fluorescence relaxation time of the measurement object from the fluorescence signal using the reference signal.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: April 9, 2013
    Assignee: Mitsui Engineering & Shipbuilding Co., Ltd.
    Inventors: Kyouji Doi, Shigeyuki Nakada, Hironori Hayashi, Kazuteru Hoshishima
  • Patent number: 8330124
    Abstract: A fluorescence detection device for a flow site meter emits laser light intensity-modulated in accordance with a modulation signal and acquires a fluorescent signal of fluorescence emitted from a measurement object that passes through a measurement point of the laser light. The fluorescence detection device generates, separately from the modulation signal, a reference signal having a frequency different from a frequency of the modulation signal and a phase in synchronization with a phase of the modulation signal. The fluorescence detection device determines a fluorescent relaxation time of the measurement object from the fluorescent signal by using the reference signal.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: December 11, 2012
    Assignee: Mitsui Engineering & Shipbuilding Co., Ltd.
    Inventors: Kyouji Doi, Shigeyuki Nakada, Hironori Hayashi, Kazuteru Hoshishima
  • Publication number: 20120282649
    Abstract: Disclosed herein is a fluorescence detecting apparatus. The fluorescence detecting apparatus includes a light-receiving element that receives fluorescence emitted from an object to be measured irradiated with laser light modulated at a predetermined frequency and outputs a fluorescence signal at an adjusted output level; a signal processing unit that mixes the outputted fluorescence signal and a modulation signal with the frequency to generate fluorescence data including information about phase and intensity; and an analyzing device that calculates a first phase shift of the fluorescence emitted from the object to be measured with respect to the modulation signal, calculates a second phase shift by correcting the calculated first phase shift depending on conditions for adjusting the output level, and calculates a fluorescence relaxation time of the fluorescence emitted from the object to be measured using the calculated second phase shift.
    Type: Application
    Filed: January 5, 2011
    Publication date: November 8, 2012
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Hironori Hayashi, Shigeyuki Nakada, Kazuteru Hoshishima, Kyouji Doi
  • Publication number: 20120085933
    Abstract: A fluorescence emitted by a measurement object at a measurement point is measured. When the fluorescence is measured, a measurement object is irradiated with laser light whose intensity is time-modulated by using a modulation signal at a predetermined frequency. Then, the fluorescence emitted by the measurement object is formed to a flux of the fluorescence having uniform distribution of light intensity, and a plurality of partial fluorescent signals are generated by receiving a plurality of divided portions of the flux of the fluorescence. At least some of the partial fluorescent signals are added altogether to generate a single fluorescent signal. Finally, a fluorescence relaxation time of the fluorescence emitted by the measurement object is calculated from the generated fluorescent signal by using the modulation signal. When fluorescence intensity of the fluorescence calculated from the fluorescent signal exceeds a predetermined threshold, the partial fluorescent signals to be added are limited in number.
    Type: Application
    Filed: May 27, 2010
    Publication date: April 12, 2012
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Kyouji Doi, Hironori Hayashi, Kazuteru Hoshishima, Yumi Asano
  • Publication number: 20120025098
    Abstract: When receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit, a fluorescence detection device generates a modulation signal for modulating the intensity of the laser light and modulates the laser light using the modulation signal. The fluorescence detection device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light, and calculates, from the fluorescent signal, a fluorescence intensity and the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detection device controls the operation amounts of the signal level of a DC component of the modulation signal and the gain of amplification just after the output of the fluorescent signal so that the value of a fluorescence intensity signal falls within a preset range.
    Type: Application
    Filed: February 8, 2010
    Publication date: February 2, 2012
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Shigeyuki Nakada, Kyouji Doi
  • Publication number: 20110284770
    Abstract: A fluorescence detecting device generates a modulation signal for modulating an intensity of laser light and modulates the laser light by using the modulation signal, when receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit. The fluorescence detecting device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light and calculates, from the fluorescent signal, the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detecting device controls the frequency of the modulation signal so that the value of the phase delay comes close to a preset value. The fluorescence detecting device calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object by using a phase delay obtained under the condition of frequency of the modulation signal at the time when the control is settled.
    Type: Application
    Filed: February 8, 2010
    Publication date: November 24, 2011
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD
    Inventors: Shigeyuki Nakada, Kyouji Doi
  • Publication number: 20110266462
    Abstract: When a fluorescence relaxation time of a fluorochrome is determined using a measurement object obtained by attaching the fluorochrome to an analyte, a first laser beam is intensity-modulated by a modulation signal with a frequency of f1 and a second laser beam is intensity-modulated by a modulation signal with a frequency of f2. A first fluorescent signal and a second fluorescent signal are obtained. The first fluorescent signal is mixed with the modulation signal with a frequency of f1 to produce first fluorescence data P1, and the second fluorescent signal is mixed with the modulation signal with a frequency of f2 to produce second fluorescence data P2. The fluorescence relaxation time is calculated using fluorescence data obtained by subtracting the result of multiplication of the second fluorescence data P2 by a second constant from the result of multiplication of the first fluorescence data P1 by a first constant.
    Type: Application
    Filed: January 4, 2010
    Publication date: November 3, 2011
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD
    Inventor: Kyouji Doi
  • Publication number: 20110168916
    Abstract: Fluorescence detection device employed in a flow site meter emits laser light intensity-modulated by a modulation signal and acquires the fluorescence signal of fluorescence emitted from a measurement object passing through a measurement point of the laser light. The device generates the reference signal, separately from the modulation signal, the reference signal having a frequency different from the frequency of the modulation signal and having a phase synchronized with a phase of the modulation. The device determines fluorescence relaxation time of the measurement object from the fluorescence signal using the reference signal.
    Type: Application
    Filed: September 16, 2009
    Publication date: July 14, 2011
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Kyouji Doi, Shigeyuki Nakada, Hironori Hayashi, Kazuteru Hoshishima
  • Publication number: 20110168917
    Abstract: A fluorescence detection device for a flow site meter emits laser light intensity-modulated in accordance with a modulation signal and acquires a fluorescent signal of fluorescence emitted from a measurement object that passes through a measurement point of the laser light. The fluorescence detection device generates, separately from the modulation signal, a reference signal having a frequency different from a frequency of the modulation signal and a phase in synchronization with a phase of the modulation signal. The fluorescence detection device determines a fluorescent relaxation time of the measurement object from the fluorescent signal by using the reference signal.
    Type: Application
    Filed: September 16, 2009
    Publication date: July 14, 2011
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO., LTD.
    Inventors: Kyouji Doi, Shigeyuki Nnakada, Hironori Hayashi, Kazuteru Hoshishima
  • Publication number: 20100193703
    Abstract: When FRET (Fluorescence Resonance Energy Transfer) detection of a large number of samples is performed in a short time for a sample consisting of a donor molecule and an acceptor molecule, the donor molecule is irradiated at first with first laser light used for exciting a donor molecule subjected to intensity modulation at a frequency of f+?f, the accepter molecule is irradiated with second laser light used for exciting an acceptor molecule subjected to intensity modulation at a frequency of f, and fluorescence emitted from the accepter molecule is received. From a fluorescence signal thus received, a first signal component of fluorescence emitted from the accepter molecule through FRET, and a second signal component of fluorescence emitted from an accepter molecule excited through irradiation with the second laser light are extracted. Phase lags of the first and second signal components thus extracted are then calculated and the presence of generation of FRET is judged based on these phase lags.
    Type: Application
    Filed: August 30, 2007
    Publication date: August 5, 2010
    Applicant: Mitsui Engineering & Shipbuilding Co., Ltd.
    Inventors: Noriaki Kimura, Shigeyuki Nakada, Kyouji Doi