Patents by Inventor Kytai NGUYEN

Kytai NGUYEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticles containing extracellular matrix for drug delivery
    Patent number: 11491115
    Abstract: Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering ?-Klotho (?Klotho) protein or DNA to a subject.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 8, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Connie Hsia, Yi Hong, Orson W. Moe, Kytai Nguyen
  • MUSSEL INSPIRED NANCOMPOSITE ADHESIVES FOR BIOMEDICAL APPLICATIONS
    Publication number: 20210106718
    Abstract: A tissue adhesive composition comprises a biodegradable adhesive; nanoparticles; and a tissue regenerative agent. Methods of adhering tissue comprise applying a film of the tissue adhesive composition to a first surface of a first biological tissue; contacting a second surface of a second biological tissue with the first surface of the first biological tissue, wherein the film of the composition is positioned between and in contact with both the first surface and the second surface.
    Type: Application
    Filed: October 13, 2020
    Publication date: April 15, 2021
    Inventors: YI HONG, Kytai NGUYEN, Philippe ZIMMERN, Jun LIAO
  • Compositions comprising antisense-encoded erythropoietin receptor and use thereof
    Patent number: 10912791
    Abstract: Provided herein are nanoparticles comprising antisense-encoded erythropoietin receptor (RopE) alone or in combination with erythropoietin receptor (EpoR). Also provided herein are methods of treating or preventing lungs disorders comprising administering RopE alone or in combination with EpoR.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: February 9, 2021
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Connie Hsia, Orson W. Moe, Kytai Nguyen
  • Multifunctional nanoparticle systems and methods for cancer diagnosis and combination therapy
    Patent number: 10765745
    Abstract: In one aspect, compositions comprising a population of core-shell nanoparticles are described herein. In some cases, the population of core-shell nanoparticles comprises a core component and a shell component encapsulating or surrounding the core component. Additionally, one or more radiosensitizers are disposed in or dispersed throughout the core component, or an interior region of the core component. Similarly, one or more chemotherapeutic agents are disposed in or dispersed throughout the shell component, or an interior region of the shell component. Moreover, in some cases, the core component is formed from one or more biodegradable polymers. Further, in some instances, the shell component is formed from one or more stimuli responsive polymers, such as a temperature-responsive polymer and/or pH-responsive polymer.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 8, 2020
    Assignee: Board of Regents, the University of Texas System
    Inventors: Kytai Nguyen, Jyothi Menon, Debabrata Saha
  • COMPOSITIONS COMPRISING ANTISENSE-ENCODED ERYTHROPOIETIN RECEPTOR AND USE THEREOF
    Publication number: 20190262376
    Abstract: Provided herein are nanoparticles comprising antisense-encoded erythropoietin receptor (RopE) alone or in combination with erythropoietin receptor (EpoR). Also provided herein are methods of treating or preventing lungs disorders comprising administering RopE alone or in combination with EpoR.
    Type: Application
    Filed: September 11, 2017
    Publication date: August 29, 2019
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Connie HSIA, Orson W. MOE, Kytai NGUYEN
  • NANOPARTICLES CONTAINING EXTRACELLULAR MATRIX FOR DRUG DELIVERY
    Publication number: 20180207107
    Abstract: Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering ?-Klotho (?Klotho) protein or DNA to a subject.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 26, 2018
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Connie HSIA, Yi HONG, Orson W. MOE, Kytai NGUYEN
  • MULTIFUNCTIONAL NANOPARTICLE SYSTEMS AND METHODS FOR CANCER DIAGNOSIS AND COMBINATION THERAPY
    Publication number: 20170065523
    Abstract: In one aspect, compositions comprising a population of core-shell nanoparticles are described herein. In some cases, the population of core-shell nanoparticles comprises a core component and a shell component encapsulating or surrounding the core component. Additionally, one or more radiosensitizers are disposed in or dispersed throughout the core component, or an interior region of the core component. Similarly, one or more chemotherapeutic agents are disposed in or dispersed throughout the shell component, or an interior region of the shell component. Moreover, in some cases, the core component is formed from one or more biodegradable polymers. Further, in some instances, the shell component is formed from one or more stimuli responsive polymers, such as a temperature-responsive polymer and/or pH-responsive polymer.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 9, 2017
    Inventors: Kytai NGUYEN, Jyothi Menon, Debabrata Saha