Abstract: The present disclosure provides CFTR modulator and phosphodiesterase 4 (PDE4) inhibitor compounds of the formula (Ia): and compositions including said compounds. The compounds can provide functionality for modulating CFTR, methods for treating an eye disease or disorder, and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4 in a biological system or biological sample, for treating an inflammatory disease or disorder, and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Abstract: The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.

Abstract: A rotary type linear reciprocating motion device includes: a driving part rotatably driven by a motor; a rotating part installed at one surface of the driving part, the rotating part transferring a rotational force of the driving part to an applicator; and a reciprocating part installed at the other surface of the driving part, the reciprocating part converting the rotational force of the driving part into a linear reciprocating motion force, the reciprocating part transferring the linear reciprocating motion force to the applicator. The driving part includes: a driving plate having both surfaces at which the rotating part and the reciprocating part are respectively installed; and a driving belt installed at an edge of the driving plate, the driving belt being in contact with a motor shaft of the motor to allow a driving force of the motor to be transferred to the driving plate by a frictional force.

Abstract: An additive, a non-aqueous electrolyte solution including the same, and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution includes a lithium salt, a non-aqueous solvent including a propyl propionate, and a compound represented by Formula 1: wherein, in Formula 1, R1 and R2 are each independently hydrogen or a substituted or unsubstituted alkyl group having 1 to 6 carbon atoms.

Abstract: The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.

Abstract: An aerosol generation device providing a customized smoking experience and an aerosol-generating article applied thereto are provided. The aerosol generation device according to some embodiments of the present disclosure may include a housing which forms an accommodation space for accommodating an aerosol-generating article, and a heater part configured to heat the aerosol-generating article accommodated in the accommodation space to generate an aerosol. Here, the aerosol-generating article may include an aerosol-forming substrate part and an additive accommodation part in which an additive is accommodated, and the heater part may include a user control-type heater configured to heat the additive accommodation part. The user control-type heater may heat the additive accommodation part on the basis of a user input to provide a customized smoking experience according to a user's preferences.

Abstract: The present disclosure relates to an organic electroluminescent device including a first electrode; a second electrode; and at least one light-emitting layer(s) positioned between the first electrode and the second electrode, and wherein the light-emitting layer includes a host comprising a compound represented by formula 1 and a compound represented by formula 2, and a dopant comprising a compound represented by formula 3, so that the present disclosure may provide an organic electroluminescent device having high efficiency and long lifespan property.

Abstract: A separator for a lithium secondary battery, the separator including a separator substrate including a porous polymer resin and a heat resistance layer on at least one side of the separator substrate. The heat resistance layer includes a phenolic resin configured to be hardened when heated. The heat shrinkage at a high temperature is improved, and it is possible to prevent short circuit between electrodes.

Abstract: A method of calculating a bleeding site and a trajectory of a bloodstain scattered by impact includes: obtaining, by an electronic device calculating the bleeding site and the trajectory of the bloodstain scattered by impact, captured image information; analyzing the obtained captured image information, by the electronic device, and calculating a collision angle and measuring a direction angle of the bloodstain scattered by impact; calculating, by the electronic device, a coordinate value of the bleeding site by using a linear trajectory method; calculating, by the electronic device, a trajectory of a drop of blood based on the calculated coordinate value of the bleeding site by using a parabolic trajectory method considering gravity and air resistance; and displaying and outputting, by the electronic device, a linear trajectory of the drop of blood and a parabolic trajectory considering gravity and air resistance of the drop of blood on a 3D space.

Abstract: The present disclosure provides a biomimetic cell culture apparatus that mimics interactions among organs in a human body. The present disclosure includes a plurality of culture units for culturing cells, a conduit for connecting the plurality of culture units to each other to form a circulating path, a pump unit disposed on the conduit for forming a flow in culture medium such that the culture medium circulates through the plurality of culture units, and an agitating module for agitating the plurality of culture units.

Abstract: Compounds of Formula (I), racemates, enantiomers, diastereomers thereof or pharmaceutical acceptable salts thereof, or pharmaceutical compositions containing the compounds, racemates, enantiomers, diastereomers thereof are disclosed. These compounds have GPR40 agonist activity and are capable of modulating blood glucose levels and glucose-dependent insulin secretion mechanism, and, thus, exhibit excellent glucose lowering efficacy without the risk of hypoglycemia. These compounds could be used in preventing and/or treating type 2 diabetes through adequate control of blood glucose.

Abstract: Disclosed are a display apparatus, a voice acquiring apparatus and a voice recognition method thereof, the display apparatus including: a display unit which displays an image; a communication unit which communicates with a plurality of external apparatuses; and a controller which includes a voice recognition engine to recognize a user's voice, receives a voice signal from a voice acquiring unit, and controls the communication unit to receive candidate instruction words from at least one of the plurality of external apparatuses to recognize the received voice signal.

Abstract: The present disclosure relates to a lithium secondary battery comprising a positive electrode including a positive electrode active material, a negative electrode including a negative electrode active material, and a non-aqueous electrolyte. The non-aqueous electrolyte includes an organic solvent, a lithium salt, a coumarin-based compound represented by [Chemical Formula 1], and a halogen-substituted cyclic carbonate, and the positive electrode active material includes a lithium manganese-rich oxide represented by [Chemical Formula 2].

Abstract: The present disclosure relates to a non-aqueous electrolyte including an organic solvent, a lithium salt, and a coumarin-based compound represented by the following Chemical Formula 1 and a lithium secondary battery including the non-aqueous electrolyte: in Chemical Formula 1, R is a substituent including one or more elements selected from the group consisting of C, O, N, B, S, P, Si, and F, and n is an integer of 1 to 6.

Abstract: An aerosol-generating article with improved cooling performance and flavor persistence and a method of producing the same are provided. The aerosol-generating article according to some embodiments of the present disclosure may include an aerosol-forming substrate part and a cooling part disposed downstream of the aerosol-forming substrate part configured to cool an aerosol formed in the aerosol-forming substrate part, and a sheet-type material may be disposed in a rolled or folded form in the cooling part. Here, the sheet-type material is a material including a flavoring and may serve as a cooling material as well as a flavor expressing material to improve flavor persistence and cooling performance of the aerosol-generating article.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: An aerosol-generating article with improved cooling performance and flavor persistence and a method of producing the same are provided. The aerosol-generating article according to some embodiments of the present disclosure may include an aerosol-forming substrate part and a cooling part disposed downstream of the aerosol-forming substrate part and configured to cool an aerosol formed in the aerosol-forming substrate part, and a sheet-type material may be disposed on an inner wall of the cooling part. Here, the sheet-type material is a material including a flavoring and may serve as a cooling material as well as a flavor expressing material to improve cooling performance and flavor persistence of the aerosol-generating article.

Abstract: A multilayer electronic component includes a body including a dielectric layer and an internal electrode alternately disposed with the dielectric layer interposed therebetween in a first direction; and an external electrode disposed on the body and connected to the internal electrode, wherein 0.46 to 1.08 at% is a range of an indium (In) content compared to nickel (Ni) and indium (In) contents in a surface layer portion of the internal electrode.

Abstract: The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.

Abstract: A display device includes a display panel having a display area comprising pixels and a non-display area surrounding the display area, an encapsulation substrate which faces the display panel and is disposed on a surface of the display panel, and a sealing member disposed in the non-display area and interposed between the display panel and the encapsulation substrate for bonding. The display panel comprises a base substrate and a first conductive layer disposed on a first surface of the base substrate, the base substrate provides a through hole defined in a part of the non-display area to penetrate the base substrate in a thickness direction, the first conductive layer comprises a signal line disposed in a part of the non-display area and filling the through hole, and the sealing member does not overlap the first conductive layer and the through hole in the thickness direction.