Abstract: Provided is a method of treating cancer, particularly cancers associated with an overexpression of polo-like kinase (Plk1), comprising administering a compound of formula (I) or a pharmaceutically acceptable salt thereof in which ring A, X1, X2, X3, X4, X5, R2, R3, R4, n, bond a, and bond b are described herein. Exemplary compounds of formula (I) and pharmaceutically acceptable salts thereof, especially those that selectively inhibit the polo box domain of Plk1, also are provided.

Abstract: Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

Abstract: The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

Abstract: The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected pho-phoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

Abstract: Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament.

Abstract: A hydraulic power train for a hybrid vehicle is provided, which can selectively transmit power of a hydraulic driving unit or an engine to driving wheels using a double pinion planetary gear and a synchro sleeve in addition to the hydraulic driving unit. More specifically, a hydraulic power train for a hybrid vehicle is provided, which can achieve various driving modes and maximize the fuel efficiency, by combining a hydraulic driving unit, a double pinion planetary gear, and a synchro-type transmission to implement a continuously variable transmission for a hybrid vehicle that can selectively transmit power of an engine or a hydraulic driving unit.

Abstract: Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds. The compounds of the invention have potential therapeutic activity in view of their binding and inhibitory activities towards Plk1. They are based on the amino acid sequence PLHSpT (phosphorylated Thr). The PEG moiety, when present, is covalently attached at the N-terminus.

Abstract: Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament.

Abstract: Isolated peptide substrates of Plk1 and nucleic acids encoding these peptides are disclosed. The peptides include two to ten repeats of the amino acid sequence set forth as X1X2AX3X4X5PLHSTX6X7X8X9X10X11X12 (SEQ ID NO: 1), in which within each repeat X1, X2, X6, X7, X8, X9, X10, X11, and X12 are each independently any amino acid or no amino acid, and X3 and X4 are each independently any amino acid. Methods of using these peptides to detect Plk1 activity in a sample are also disclosed. In some examples, the method includes contacting a sample with a disclosed peptide substrate of Plk1 in the presence of adenosine triphosphate, or an analog thereof, for a period of time sufficient for Plk1 to phosphorylate the PBIPtide. The presence and/or amount of the phosphorylated and/or the unphosphorylated peptide is detected, thereby detecting and/or quantitating Plk1 kinase activity in the sample.

Abstract: The amino acid sequence of a polo box is provided based on residue-by-residue mutation and analysis of phenotype. Additional polo boxes in the polo kinase protein located between the first polo box and the carboxy terminal are provided. Compositions and methods are provided for obtaining inhibitors of polo box function, for use as therapeutics for treatment of cancer, infection a fungi, protozoans, and helminths, for arthropod infestation of a subject, and for treatment of tumors.

Abstract: A charged coupled device structure (CCD) and a method for fabricating the CCD structure, which induces a maximum potential distribution difference by utilizing gate insulation films having different physical properties. The charged coupled device includes a semiconductor substrate, a first insulation layer formed on the semiconductor substrate, a plurality of first electrodes spaced at fixed intervals over the first insulation layer, a second insulation layer formed only between the plurality of first electrodes and the first insulation layer, a third insulation layer formed over the entire exposed surface of the first electrodes and the first insulation layer, and a plurality of second electrodes formed only on the surface area corresponding to spaces between the plurality of first electrodes. This gate insulation layers having different physical properties induces a maximum potential distribution difference in a semiconductor substrate with a dielectric constant difference between the insulation layers.

Abstract: A semiconductor device package including a semiconductor chip formed with a plurality of bonding pads including at least two multiple-bonding pads to which identical signals are transmitted; a substrate provided with a chip-support and a plurality of conductors for electrically connecting the chip to external devices; a plurality of bonding wires for electrically connecting said bonding pads to the conductors including multiple-bonding wires for electrically connecting the multiple-bonding pads to corresponding conductors; and a current looper for screening magnetic fields generated from the bonding wires so that the magnetic fields cannot interfere each other, the current looper being located between the multiple-bonding wires and bonded to the substrate at both ends.

Abstract: A charged coupled device structure (CCD) and a method for fabricating the CCD structure, which induces a maximum potential distribution difference by utilizing gate insulation films having different physical properties. The charged coupled device includes a semiconductor substrate, a first insulation layer formed on the semiconductor substrate, a plurality of first electrodes spaced at fixed intervals over the first insulation layer, a second insulation layer formed only between the plurality of first electrodes and the first insulation layer, a third insulation layer formed over the entire exposed surface of the first electrodes and the first insulation layer, and a plurality of second electrodes formed only on the surface area corresponding to spaces between the plurality of first electrodes. This gate insulation layers having different physical properties induces a maximum potential distribution difference in a semiconductor substrate with a dielectric constant difference between the insulation layers.

Abstract: An impregnated pellet for a cathode structure according to the present invention is produced by forming a plurality of voids by arranging a plurality of metal rods within a cylinder of heat-resisting metal open at both ends thereof, impregnating the voids with electron emission material, thereby to prepare a rod-shaped pellet base, cutting the rod-shaped pellet base into respective impregnated pellets of a predetermined thickness, and finishing the cut surfaces of the pellets by vibration and tilting operation of working plate. The impregrate pellets can be extensively applied to a cathode-ray tube, an electron tube and the like, which require high current density.

Abstract: An electro static discharge protection circuit capable of achieving an improvement in ESD protection characteristic by an isolation between the inner cell ground and the ESD protection circuit ground and use of a field oxide transistor. The protection circuit includes first and third p type wells formed at a peripheral circuit region of a n type substrate and a second p type well formed at a cell region of the substrate, a first p.sup.+ type impurity-diffused region, first, second and third n.sup.+ type impurity-diffused regions, all of the impurity-diffused regions being formed in the first p type well, a second p.sup.+ type impurity-diffused region formed in the second p type well, a third p.sup.+ type impurity-diffused region, fourth, fifth and sixth n.sup.

Abstract: A coil integrated semi-conductor device and method of making the same is disclosed. First to third metal layers are in sequence formed on a semi-conductor device. The first and third metal layers of equal width are connected to each other through contact holes, to define a hollow region which is filled with the second metal layer disposed centrally therein and a circumferential region surrounding the second metal layer. The first and third metal layers are used as a coil and the second metal layer is used as a core of magnetic material. The circumferential region surrounding the second metal layer is filled with different dielectric layers. According to the invention, a coil capable of exerting the magnetic field effect can be integrated in a semiconductor chip. This makes it possible contemplation of compactness, integration and preciseness of devices in the form that the coil is wound around the care.

Abstract: A method for manufacturing an impregnated cathode wherein an impregnated pallet is fixedly fitted in a cathode cup. The method comprises the step of disposing electron emitting materials together with a porous pallet in the cathode cup and impregnating the electron emitting materials in the porous pallet to produce the impregnated pallet. The cathode cup is constituted by alloying an oxidative metal or alloy, such as silicon (Si), nickel (Ni) or chromium (Cr), which tends to react oxidatively with the electron emitting materials, in a high heat-resistant metal. In the impregnation process, a bonding of the impregnated pallet to the cathode cup can be achieved by an oxidation reaction between the electron emitting matetrials in the impregnated pallet and the oxidative material in the cathode cup, without any expensive brazing metals or alloys. As a result, it is possible to reduce the manufacturing cost and the total manufacturing processes.

Abstract: A method for manufacturing an impregnated cathode comprising the steps of forming a porous pallet having a plurality of pores by sintering metal powder at a high temperature in a reducing atmosphere and fitting the porous pallet tightly in a cathode ring made of a metal containing an oxidizable material such as silicon, nickel or chromium. In the porous pallet, an electron radiating material is impregnated which is able to react with the oxidizable material of the cathode ring, so that an fixing between the pallet and the cathode ring is achieved by the reaction between the electron radiating material and the oxidizable material. In accordance with the method, the thickness of the cathode body can be greatly reduced, thereby enabling the performance of the impregnated cathode to be improved. Also, the manufacturing process can be simplified, thereby improving the productivity.