Patents by Inventor Ladislav Jankovic
Ladislav Jankovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11707253Abstract: The present invention relates to a monitoring apparatus for monitoring an ablation procedure. The monitoring apparatus comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object that is ablated. The monitoring apparatus further comprises an ablation depth determination unit for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object and for determining when the ablation has reached a desired progression.Type: GrantFiled: August 22, 2021Date of Patent: July 25, 2023Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Erik Harks, Szabolcs Deladi, Jan F. Suijver, Ladislav Jankovic, Yan Shi, Wouter H. Rensen, Maya E. Barley, Nijs C. Van Der Vaart
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Publication number: 20210378629Abstract: The present invention relates to a monitoring apparatus for monitoring an ablation procedure. The monitoring apparatus comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object that is ablated. The monitoring apparatus further comprises an ablation depth determination unit for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object and for determining when the ablation has reached a desired progression.Type: ApplicationFiled: August 22, 2021Publication date: December 9, 2021Inventors: Erik HARKS, Szabolcs DELADI, Jan F. SUIJVER, Ladislav JANKOVIC, Yan SHI, Wouter H. RENSEN, Maya E. BARLEY, Nijs C. VAN DER VAART
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Patent number: 11166691Abstract: A system (200) includes a first imaging system (201) that utilizes first radiation to image an interior region of interest of a subject, including a first agent in the region of interest and a second imaging system (218) that utilizes second radiation to image a second agent in the region of interest, wherein an output of the second imaging system is used to trigger the first imaging system to scan the region of interest, including the first agent in the region of interest.Type: GrantFiled: June 12, 2012Date of Patent: November 9, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Roland Proksa, Ladislav Jankovic
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Patent number: 11096659Abstract: The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.Type: GrantFiled: January 16, 2018Date of Patent: August 24, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Erik A. Harks, Szabolcs Deladi, Jan F. Suijver, Ladislav Jankovic, Yan Shi, Wouter H. Rensen, Maya E. Barley, Nijs C. Van Der Vaart
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Publication number: 20200253481Abstract: A photoacoustic medical-imaging device includes a wavelength conversion assembly (108) configured for outputting laser pulses at a targeted wavelength. It also includes a photoacoustic probe configured for acoustic coupling to a patient, for directing the pulses, and for acquiring, in response, radiofrequency data for photoacoustic imaging. It may include an optical fiber bundle (120) that comprises an optical fiber having an input end, and be configured for illuminating, with a homogenous beam, so as to conform to an acceptance angle (160) of the fiber at that end. It may also include a light collimator, and a diffuser for receiving the outputted laser pulses from the collimator. The diffuser may be configured for spreading a focus of the pulsed light (148) over an input aperture of the bundle to equalize the light received by different constituent optical fibers of the bundle. The assembly may include a dye cell (132), and may reside in the device.Type: ApplicationFiled: May 1, 2020Publication date: August 13, 2020Inventors: KONSTANTIN MASLOV, TODD NICHOLAS ERPELDING, LADISLAV JANKOVIC, LIHONG WANG
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Patent number: 10271733Abstract: Bubbles (118-122) are utilized in some embodiments as part of a photoacoustic contrast agent (162) and, in some embodiments, to localize one or more locations (126-38) of a source of acoustic energy. The bubbles, such as microbubbles, can be used in proximity of nanoparticles of a first photoacoustic contrast agent, thereby affording a second photoacoustic contrast agent. The bubbles can intercept and re-radiate acoustic energy emitted by light-based activation of the first photoacoustic contrast agent in the immediate vicinity of the bubbles. As a further option, if the nanoparticles permeate further to tissue structures but remain in close enough proximity, their positions can be triangulated by the nearby bubbles, based on direction (144-148) and time delays (150-160) of ultrasound received by a transducer array.Type: GrantFiled: December 12, 2011Date of Patent: April 30, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventors: William Tao Shi, Ladislav Jankovic
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Publication number: 20180199911Abstract: The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.Type: ApplicationFiled: January 16, 2018Publication date: July 19, 2018Inventors: Erik Harks, Szabolcs Deladi, Jan F. Suijver, Ladislav Jankovic, Yan Shi, Wouter H. Rensen, Maya E. Barley, Nijs C. Van Der Vaart
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Patent number: 9901321Abstract: The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.Type: GrantFiled: January 8, 2010Date of Patent: February 27, 2018Assignee: Koninklijke Philips N.V.Inventors: Erik Harks, Szabolcs Deladi, Jan Frederik Suijver, Ladislav Jankovic, Yan Shi, Wouter Harry Jacinth Rensen, Maya Barley, Nijs Cornelis Van Der Vaart
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Patent number: 9743881Abstract: Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data.Type: GrantFiled: March 27, 2012Date of Patent: August 29, 2017Assignee: Koninklijke Philips N.V.Inventors: Emil Radulescu, Sheng-Wen Huang, Ramon Erkamp, Ladislav Jankovic, Yan Shi, Khalid Shahzad
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Publication number: 20150272444Abstract: A photoacoustic medical-imaging device includes a wavelength conversion assembly (108) configured for outputting laser pulses at a targeted wavelength. It also includes a photoacoustic probe configured for acoustic coupling to a patient, for directing the pulses, and for acquiring, in response, radiofrequency data for photoacoustic imaging. It may include an optical fiber bundle (120) that comprises an optical fiber having an input end, and be configured for illuminating, with a homogenous beam, so as to conform to an acceptance angle (160) of the fiber at that end. It may also include a light collimator, and a diffuser for receiving the outputted laser pulses from the collimator. The diffuser may be configured for spreading a focus of the pulsed light (148) over an input aperture of the bundle to equalize the light received by different constituent optical fibers of the bundle. The assembly may include a dye cell (132), and may reside in the probe.Type: ApplicationFiled: August 14, 2013Publication date: October 1, 2015Inventors: Konstantin Maslov, Todd Nicholas Erpelding, Ladislav Jankovic, Lihong Wang
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Publication number: 20140121510Abstract: A system (200) includes a first imaging system (201) that utilizes first radiation to image an interior region of interest of a subject, including a first agent in the region of interest and a second imaging system (218) that utilizes second radiation to image a second agent in the region of interest, wherein an output of the second imaging system is used to trigger the first imaging system to scan the region of interest, including the first agent in the region of interest.Type: ApplicationFiled: June 12, 2012Publication date: May 1, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Roland Proksa, Ladislav Jankovic
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Publication number: 20140088418Abstract: Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data.Type: ApplicationFiled: March 27, 2012Publication date: March 27, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Emil Radulescu, Sheng-Wen Huang, Ramon Erkamp, Ladislav Jankovic, Yan Shi, Khalid Shahzad
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Patent number: 8677829Abstract: Apparatus, systems and methods are provided for production and integration of compact illumination schemes. More particularly, disclosed embodiments relate to apparatus/systems and methods for production of highly compact illumination schemes, whereby photoacoustic waves are induced in a target sample. Additionally, the disclosed apparatus/systems and methods are effective to produce compact and portable integrated transducer-illumination arrays. Apparatus disclosed generally include at least one lighting source and a beamsplitting assembly. Systems disclosed generally include one or more apparatus for the production of compact lighting schemes, an ultrasonic transducer assembly and means for coupling the one or more apparatus and US transducer assembly with a target sample.Type: GrantFiled: October 13, 2008Date of Patent: March 25, 2014Assignee: Koninklijke Philips N.V.Inventors: Khalid Shahzad, Ladislav Jankovic
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Patent number: 8617148Abstract: A tissue ablation device employs one or more energy emitters (21) and one or more photoacoustic sensors (22) in a cooperative arrangement for applying a tissue ablation therapy to a tissue (60). In operation, the energy emitters (21) emit a tissue ablation beam (TA) into a target portion of the tissue (60) to form a lesion (61) therein, and alternatively or concurrently emit a photoexcitation beam (PE) into the target portion of the tissue (60) to excite a photoacoustic response from the tissue (60). The photoacoustic sensor(s) (22) sense the photoacoustic response of the tissue (60).Type: GrantFiled: December 15, 2008Date of Patent: December 31, 2013Assignee: Koninklijke Philips N.V.Inventors: Robert Manzke, Raymond Chan, Ladislav Jankovic, Daniel R. Elgort, Khalid Shahzad
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Publication number: 20130281848Abstract: Bubbles (118-122) are utilized in some embodiments as part of a photoacoustic contrast agent (162) and, in some embodiments, to localize one or more locations (126-38) of a source of acoustic energy. The bubbles, such as microbubbles, can be used in proximity of nanoparticles of a first photoacoustic contrast agent, thereby affording a second photoacoustic contrast agent. The bubbles can intercept and re-radiate acoustic energy emitted by light-based activation of the first photoacoustic contrast agent in the immediate vicinity of the bubbles. As a further option, if the nanoparticles permeate further to tissue structures but remain in close enough proximity, their positions can be triangulated by the nearby bubbles, based on direction (144-148) and time delays (150-160) of ultrasound received by a transducer array.Type: ApplicationFiled: December 12, 2011Publication date: October 24, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: William Tao Shi, Ladislav Jankovic
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Patent number: 8328721Abstract: A system for the determination of optical coefficients in an object including an ultrasonic scanner for recording first and second pulse echoes before and after the object has been illuminated with a heating light beam from a light source. An evaluation unit determines a map of temperature increase caused by the heating light beam inside the object based on apparent displacements showing up between the second and first pulse echoes.Type: GrantFiled: September 18, 2007Date of Patent: December 11, 2012Assignee: Koninklijke Philips Electronics N.V.Inventors: David Savery, Ladislav Jankovic, Ajay Anand
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Publication number: 20120004547Abstract: The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.Type: ApplicationFiled: January 8, 2010Publication date: January 5, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Erik Harks, Szabolcs Deladi, Jan Frederik Suijver, Ladislav Jankovic, Yan Shi, Wouter Harry Jacinth Rensen, Maya Barley, Nijs Cornelis Van Der Vaart
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Publication number: 20100280504Abstract: A tissue ablation device employs one or more energy emitters (21) and one or more photoacoustic sensors (22) in a cooperative arrangement for applying a tissue ablation therapy to a tissue (60). In operation, the energy emitters (21) emit a tissue ablation beam (TA) into a target portion of the tissue (60) to form a lesion (61) therein, and alternatively or concurrently emit a photoexcitation beam (PE) into the target portion of the tissue (60) to excite a photoacoustic response from the tissue (60). The photoacoustic sensor(s) (22) sense the photoacoustic response of the tissue (60).Type: ApplicationFiled: December 15, 2008Publication date: November 4, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Robert Manzke, Raymond Chan, Ladislav Jankovic, Daniel R. Elgort, Khalid Shahzad
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Publication number: 20100229650Abstract: Apparatus, systems and methods are provided for production and integration of compact illumination schemes. More particularly, disclosed embodiments relate to apparatus/systems and methods for production of highly compact illumination schemes, whereby photoacoustic waves are induced in a target sample. Additionally, the disclosed apparatus/systems and methods are effective to produce compact and portable integrated transducer-illumination arrays. Apparatus disclosed generally include at least one lighting source and a beamsplitting assembly. Systems disclosed generally include one or more apparatus for the production of compact lighting schemes, an ultrasonic transducer assembly and means for coupling the one or more apparatus and US transducer assembly with a target sample.Type: ApplicationFiled: October 13, 2008Publication date: September 16, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Khalid Shahzad, Ladislav Jankovic
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Publication number: 20100043557Abstract: The invention relates to an examination apparatus and a method for the determination of optical coefficients, particularly of the optical absorption coefficient (?a) in an object (1) like the body of a patient. The apparatus comprises an ultrasonic scanner (20) for recording first and second pulse echoes before and after the object (1) has been illuminated with a heating light beam (11) from a (e.g. laser) light source (10). An evaluation unit (30) determines a map of temperature increase (?T(r)) caused by the heating light beam (11) inside the object (1) based on apparent displacements showing up between the second and first pulse echoes. Furthermore, the evaluation of locally adjacent temperature increases inside the object (1) allows to determine a map of the effective scattering coefficient (?eff(r)), from which the distribution of light intensity (I(r)) inside the object (1) can be calculated.Type: ApplicationFiled: September 18, 2007Publication date: February 25, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: David Savery, Ladislav Jankovic, Ajay Anand