Patents by Inventor Lai-Kwan Chau

Lai-Kwan Chau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220339626
    Abstract: The present disclosure provides a microfluidic device, including a bottom substrate, an electrowetting-on-dielectric (EWOD) chip, a circuit board, a dielectric film, and a motor. The EWOD chip is disposed on the bottom substrate, and the circuit board is arranged on the EWOD chip. The circuit board includes a circuit area that is electrically connected to the EWOD chip, and the empty area is adjacent to the circuit area and the EWOD chip is exposed. The dielectric film is disposed on the empty area of the circuit board and covers the exposed EWOD chip. The motor is disposed under the bottom substrate, and one end of the motor has a magnetic structure, so that the magnetic structure can move closer to or away from the bottom substrate.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 27, 2022
    Inventors: Shau-Chun WANG, Lai-Kwan CHAU, Yuan-Yu CHEN
  • Patent number: 11467154
    Abstract: An optical nano-biosensing system and a method thereof are provided. The optical nano-biosensing system includes a nano-plasmonic sensing device, a high-resolution analog-to-digital converter, a signal acquisition and processing device, and an intelligent electronic device. The nano-plasmonic sensing device further includes a light-source control circuit, a sample receiver, a light detector, and a signal-amplifying circuit. The sample receiver receives a sample. The light-source control circuit generates an incident light from a light source to be projected onto the sample receiver. The light detector detects an emergent light from the sample receiver to generate a detection signal. The signal-amplifying circuit converts the detection signal to generate an amplified signal. The high-resolution analog-to-digital converter digitizes the amplified signal to generate a digital signal.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: October 11, 2022
    Assignee: National Chung Cheng University
    Inventors: Sung-Nien Yu, Tsung-Heng Tsai, Lai-Kwan Chau
  • Publication number: 20210252502
    Abstract: A microfluidic detection unit comprises at least one fluid injection section, a fluid storage section and a detection section. Each fluid injection section defines a fluid outlet; the fluid storage section is in gas communication with the atmosphere and defines a fluid inlet; the detection section defines a first end in communication with the fluid outlet and a second end in communication with the fluid inlet. A height difference is defined between the fluid outlet and the fluid inlet along the direction of gravity. When a first fluid is injected from the at least one fluid injection section, the first fluid is driven by gravity to pass through the detection section and accumulate to form a droplet at the fluid inlet, such that a state of fluid pressure equilibrium of the first fluid is established.
    Type: Application
    Filed: June 10, 2019
    Publication date: August 19, 2021
    Inventors: Yu-Chung HUANG, Yi-Li SUN, Ting-Chou CHANG, Jhy-Wen WU, Nan-Kuang YAO, Lai-Kwan CHAU, Shau-Chun WANG, Ying Ting CHEN
  • Publication number: 20210011011
    Abstract: An optical nano-biosensing system and a method thereof are provided. The optical nano-biosensing system includes a nano-plasmonic sensing device, a high-resolution analog-to-digital converter, a signal acquisition and processing device, and an intelligent electronic device. The nano-plasmonic sensing device further includes a light-source control circuit, a sample receiver, a light detector, and a signal-amplifying circuit. The sample receiver receives a sample. The light-source control circuit generates an incident light from a light source to be projected onto the sample receiver. The light detector detects an emergent light from the sample receiver to generate a detection signal. The signal-amplifying circuit converts the detection signal to generate an amplified signal. The high-resolution analog-to-digital converter digitizes the amplified signal to generate a digital signal.
    Type: Application
    Filed: February 5, 2020
    Publication date: January 14, 2021
    Inventors: Sung-Nien Yu, Tsung-Heng Tsai, Lai-Kwan Chau
  • Patent number: 10722534
    Abstract: A magnetic nanoaggregate-embedded bead (NAEB), a manufacturing method thereof and a bioparticle detection method using the same are disclosed. The magnetic NAEB has a protective nanoshell, noble metal nanoparticles, Raman reporter molecules and at least one magnetic nanoparticle. The protective nanoshell covers the noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle. The noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle form a magnetic nanoaggregate. Preferably, a chemical modification is performed on the magnetic NAEB, such that at least one targeting molecule is formed on an outer wall of the protective nanoshell, wherein a type of the targeting molecule is corresponding to a type of the bioparticle to be detected.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: July 28, 2020
    Assignee: National Chung Cheng University
    Inventors: Lai-Kwan Chau, Shih-Ying Yen
  • Publication number: 20200072828
    Abstract: A method of measuring a concentration of an analyte is provided, including: reacting a test solution including an analyte with a nanoparticle solution including a plurality of nanoparticles and an optical waveguide element to form a sandwich-like structure; and measuring evanescent wave energy of the optical waveguide element absorbed and/or scattered by the plurality of nanoparticles after the plurality of nanoparticles forming the sandwich-like structure by using a photodetector to obtain a first signal, and calculating the concentration of the analyte based on the first signal. Wherein, a detection recognition element is conjugated on a surface of each of the plurality of nanoparticles, and a capture recognition element is conjugated on a waveguide surface of the optical waveguide element.
    Type: Application
    Filed: July 10, 2019
    Publication date: March 5, 2020
    Inventors: Lai-Kwan Chau, Chang-Yue Chiang, Zong-Yu Yang, Po-Ya Chang
  • Patent number: 10351524
    Abstract: A Hydrocarbyl Carboxybetaine represented by Formula (1) is provided: wherein, n1?0 and n2>0, A is a C1-C20 alkyl group when n1>0, and A is a single bond when n1=0.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: July 16, 2019
    Assignee: National Chung Cheng University
    Inventors: Lai-Kwan Chau, Chun-Jen Huang, Wen-Hao Chen, Chao-Wen Chen
  • Patent number: 10324034
    Abstract: A self-referencing localized plasmon resonance sensing device and a system thereof are disclosed. The reference optical waveguide element is modified with a noble metal nanoparticle layer. The sensing optical waveguide element is modified with a noble metal nanoparticle layer, which is further modified with a recognition unit. The incident light is guided into the reference and the sensing optical waveguide elements to respectively generate localized plasmon resonance sensor signals. The reference and the sensing optical waveguide elements respectively have a calibration slope. The processor utilizes the calibration slopes to regulate the second difference generated by detecting with the sensing optical waveguide element. The processor utilizes a difference between the first difference, which is generated by detecting with the reference optical waveguide element, and the regulated second difference to obtain a sensor response.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: June 18, 2019
    Assignee: National Chung Cheng University
    Inventors: Lai-Kwan Chau, Chin-Wei Wu, Chang-Yue Chiang, Chien-Hsing Chen
  • Publication number: 20180200296
    Abstract: A magnetic nanoaggregate-embedded bead (NAEB), a manufacturing method thereof and a bioparticle detection method using the same are disclosed. The magnetic NAEB has a protective nanoshell, noble metal nanoparticles, Raman reporter molecules and at least one magnetic nanoparticle. The protective nanoshell covers the noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle. The noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle form a magnetic nanoaggregate. Preferably, a chemical modification is performed on the magnetic NAEB, such that at least one targeting molecule is formed on an outer wall of the protective nanoshell, wherein a type of the targeting molecule is corresponding to a type of the bioparticle to be detected.
    Type: Application
    Filed: July 12, 2017
    Publication date: July 19, 2018
    Inventors: Lai-Kwan Chau, Shih-Ying Yen
  • Patent number: 9829437
    Abstract: Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: November 28, 2017
    Assignee: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Lai-Kwan Chau, Hsing-Ying Lin, Chen-Han Huang, Ling-Hsuan Liu, Wen-Hsin Hsieh
  • Patent number: 9612197
    Abstract: A reflection-based tubular waveguide particle plasmon resonance sensing system and a sensing device thereof are provided. The sensing device includes a hollow tubular waveguide element having wall, a reflection layer disposed on one end of the wall (distal end), and a noble metal nanoparticle layer distributed on the surface of the wall. An incident light enters the wall through another end of the tubular waveguide element (proximal end) and being total internal reflected many times along the wall, then is reflected by the reflection layer and being total internal reflected many times along the wall again, and finally, the incident light exits the proximal end. Wherein, when the sample contacts the noble metal nanoparticle layer of the tubular waveguide element, the particle plasmon resonance condition is altered and hence the signal intensity of the light exiting the tubular waveguide element changes.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: April 4, 2017
    Assignee: National Chung Cheng University
    Inventors: Lai-Kwan Chau, Yu-Chung Huang, Chih-To Wang, Chien-Hsing Chen, Chang-Yue Chiang
  • Publication number: 20170001956
    Abstract: A Hydrocarbyl Carboxybetaine represented by Formula (1) is provided: wherein, n1?0 and n2>0, A is a C1-C20 alkyl group when n1>0, and A is a single bond when n1=0.
    Type: Application
    Filed: June 29, 2016
    Publication date: January 5, 2017
    Inventors: LAI-KWAN CHAU, CHUN-JEN HUANG, WEN-HAO CHEN, CHAO-WEN CHEN
  • Patent number: 9506861
    Abstract: A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: November 29, 2016
    Assignee: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Shau-Chun Wang, Lai-Kwan Chau, Ting-Chou Chang, Chao-Ching Wu
  • Patent number: 9464986
    Abstract: A multiplex fiber optic biosensor including an optical fiber, a plurality of noble metal nanoparticle layers, a plurality of light sources and a light source function generator is disclosed. The optical fiber includes a plurality of sensing regions which are unclad regions of the optical fiber so that the fiber core is exposed, wherein the noble metal nanoparticle layers are set in each sensing regions. The light sources emit light with different wavelengths, and the noble metal nanoparticle layers absorb the lights with different wavelengths, respectively. The light sources emit the lights in different timing sequences or different carrier frequencies, wherein when the lights propagate along the optical fiber in accordance with the different timing sequences or the different carrier frequencies, a detection unit detects particle plasmon resonance signals produced by interactions between the different noble metal nanoparticle layers and the corresponding analytes.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: October 11, 2016
    Assignee: National Chung Cheng University
    Inventors: Lai-Kwan Chau, Chen-Han Huang, Hisng-Ying Lin, Yu-Chia Liu
  • Publication number: 20160264602
    Abstract: A manufacturing method of silatrane with thiol group and a preservation method thereof are disclosed. (3-Mercaptopropyl)trimethoxysilane and triethanolamine are reacted for a pre-determined time at a pre-determined temperature under nitrogen atmosphere in presence or absence of catalyst, and then a recrystallization process is performed with a solvent to obtain silatrane with thiol group of formula (1). Silatrane with thiol group is dissolved in an organic solvent to preserve the silatrane with thiol group.
    Type: Application
    Filed: September 16, 2015
    Publication date: September 15, 2016
    Inventors: Wen-Hao CHEN, Lai-Kwan CHAU, Yen-Ta TSENG, Chao-Wen CHEN
  • Publication number: 20160216205
    Abstract: A reflection-based tubular waveguide particle plasmon resonance sensing system and a sensing device thereof are provided. The sensing device includes a hollow tubular waveguide element having wall, a reflection layer disposed on one end of the wall (distal end), and a noble metal nanoparticle layer distributed on the surface of the wall. An incident light enters the wall through another end of the tubular waveguide element (proximal end) and being total internal reflected many times along the wall, then is reflected by the reflection layer and being total internal reflected many times along the wall again, and finally, the incident light exits the proximal end. Wherein, when the sample contacts the noble metal nanoparticle layer of the tubular waveguide element, the particle plasmon resonance condition is altered and hence the signal intensity of the light exiting the tubular waveguide element changes.
    Type: Application
    Filed: July 22, 2015
    Publication date: July 28, 2016
    Inventors: Lai-Kwan Chau, Yu-Chung Huang, Chih-To Wang, Chien-Hsing Chen, Chang-Yue Chiang
  • Patent number: 9394320
    Abstract: A method for fixing metal onto a surface of the substrate. The present method includes steps of: providing a substrate and a mercaptoalkylsilatrane compound; dissolving the mercaptoalkylsilatrane compound in a solvent; performing a condensation reaction of the substrate with and the dissolved mercaptoalkylsilatrane compound to complete the surface modification of the substrate; and performing a covalent bonding process to metal with the mercaptoalkylsilatrane compound already modified onto the surface of the substrate to fix the metal onto the surface of the substrate.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 19, 2016
    Assignee: National Chung Cheng University
    Inventors: Lai-Kwan Chau, Wen-Hao Chen, Yen-Ta Tseng, Chin-Wei Wu, Chao-Wen Chen
  • Publication number: 20160169797
    Abstract: A self-referencing localized plasmon resonance sensing device and a system thereof are disclosed. The reference optical waveguide element is modified with a noble metal nanoparticle layer. The sensing optical waveguide element is modified with a noble metal nanoparticle layer, which is further modified with a recognition unit. The incident light is guided into the reference and the sensing optical waveguide elements to respectively generate localized plasmon resonance sensor signals. The reference and the sensing optical waveguide elements respectively have a calibration slope. The processor utilizes the calibration slopes to regulate the second difference generated by detecting with the sensing optical waveguide element. The processor utilizes a difference between the first difference, which is generated by detecting with the reference optical waveguide element, and the regulated second difference to obtain a sensor response.
    Type: Application
    Filed: February 19, 2016
    Publication date: June 16, 2016
    Inventors: Lai-Kwan CHAU, Chin-Wei WU, Chang-Yue CHIANG, Chien-Hsing CHEN
  • Publication number: 20160139052
    Abstract: Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.
    Type: Application
    Filed: May 18, 2015
    Publication date: May 19, 2016
    Inventors: LAI-KWAN CHAU, HSING-YING LIN, CHEN-HAN HUANG, LING-HSUAN LIU, WEN-HSIN HSIEH
  • Patent number: 9140857
    Abstract: Disclosed is a double-sided grating waveguide biosensor. The double-sided grating waveguide biosensor is used to sense the properties of a sample solution. The double-sided grating waveguide biosensor comprises a sequential stack of a plastic grating having a grating part, a waveguide layer having a double-sided grating structure, and a channel chip. Furthermore, the sample solution is guided into the channel chip; the light beam is coupled into the waveguide layer via the double-sided grating structure, propagates in the waveguide layer, and penetrates outward. The double-sided waveguide biosensor detects the properties of the sample solution via a variation of a light beam intensity of the outgoing light beam.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: September 22, 2015
    Assignee: National Chung Cheng University
    Inventors: Wen-Hsin Hsieh, Lai-Kwan Chau, Hsun-Yuan Li, Wei-Chun Hsu