Abstract: The present invention discloses a fiber-optic localized plasmon resonance (FO-LPR) sensing device and a sensing system thereof, the FO-LPR sensing system includes a light source, a FO-LPR sensing device and a detector, and the light source provides a light beam entered into the FO-LPR sensing device, and the detector generates a detected signal according to an emergent light from the FO-LPR sensing device. The FO-LPR sensing device includes an optical fiber, a noble metal nanoparticle layer and a filter film layer. The filter film layer is having a porous material, and the porous material comes with a pore diameter or a property selected according to a feature of a sample, while an interfering substance in the sample is isolated.

Abstract: A bio-sensing system comprises a light source, a bio-sensing apparatus, a detecting platform, and a processing unit. A bio-sensing apparatus further comprising a substrate, a sample with at least one analyte, at least one grating bound on the substrate for diffracting a light beam in a reflection mode and outputting at least one output light beam, a plurality of nanoparticles being bound on one side of the grating, a molecular recognition unit bound on said nanoparticle surface, and a cover plate covering the nanoparticle-modified side of the substrate. The detecting platform receives a signal while the at least one output light beam passing through the bio-sensing apparatus. The processing unit couples with the detecting platform for receiving and analyzing the signal.

Abstract: The present invention relates to a photoelectrical feedback sensing system. A first light signal passes through the sensing apparatus. A second light signal corresponding to a characteristic of a sample within the sensing apparatus is outputted from the sensing apparatus. The first photo detector receives the first light signal and outputs a first electric signal corresponding to the intensity of the first light signal. The second photo detector outputs a second electric signal corresponding to the intensity of the second light signal. A driving signal is generated by the micro-processor to drive the light-emitting unit. The micro-processor receives the second electric signal and converts the second electric signal into a digital signal. The feedback circuit modulates the driving signal for maintaining the optical stability of the first light signal so that the sensing system is less affected by environmental temperature fluctuation and noise interferences.

Abstract: A nanoaggregate embedded bead is formed from an inner core formed of comprising metallic nanoparticles and Raman active reporter molecules, an outer shell, and single-domain antibodies to target the bead to a specific target. The nanoaggregate embedded bead may be used in methods to detect analytes or pathogens in biological or environmental samples using Raman spectroscopy.

Abstract: The present invention discloses a localized plasmon resonance sensing device and a fiber optic structure. The device comprises an optical fiber and a noble metal nanoparticle layer. The optical fiber has a plurality of notches, and such notches are located on the side surface of the optical fiber. The noble metal nanoparticle layer is located at the notch. As a result, when a light is launched into the optical fiber, a detecting unit can be used to detect a localized plasmon resonance signal which is generated by the interaction between the noble metal nanoparticle layer and the light.

Abstract: The present invention discloses a fiber-optic localized plasmon resonance (FO-LPR) sensing device and a sensing system thereof, the FO-LPR sensing system includes a light source, a FO-LPR sensing device and a detector, and the light source provides a light beam entered into the FO-LPR sensing device, and the detector generates a detected signal according to an emergent light from the FO-LPR sensing device. The FO-LPR sensing device includes an optical fiber, a noble metal nanoparticle layer and a filter film layer. The filter film layer is having a porous material, and the porous material comes with a pore diameter or a property selected according to a feature of a sample, while an interfering substance in the sample is isolated.

Abstract: The present invention discloses a LPR sensing device and a LPR sensing system comprising a LPR sensing device, a light source, a detecting unit and a processing unit. The LPR sensing device comprises a sensing substrate and a noble metal nanoparticle layer, and the noble metal nanoparticle layer is disposed on the sensing substrate and has noble metal nanoparticles with diameter of 2˜12 nm. An analyte adsorbed on the surface of the noble metal nanoparticle layer generates a dielectric environmental change, resulting in a change of the LPR band. Comparing noble metal nanoparticles with different particle diameters, small noble metal nanoparticles provide better sensing sensitivity to a compound with a small molecular weight.

Abstract: A sensing system comprises a light source, an optical fiber, a plurality of noble metal nano-particles, a micro-fluidic module and a photo detector. The optical fiber couples an incident light. The plurality of noble metal nano-particles are disposed on a surface of the optical fiber to form a noble metal nano-particle submonolayer, the noble metal nano-particles are substantially separated from each adjacent noble metal nano-particles such that the conductivity of the noble metal nano-particle submonolayer is smaller than that of a metal film. The micro-fluidic module accommodates the optical fiber and a sample, and the sample is driven to contact with the noble metal nano-particles. The photo detector detects an emergent light from the optical fiber. When the incident light interacts with the noble metal nano-particles, a signal derived from localized surface plasmon resonance in form of attenuated light or elastic scattered light is outputted through the photo detector.

Abstract: A plasmon resonance sensing system includes a light source, a waveguide component and a photon detector. The light source provides an incident light. The waveguide component has a tubular internal wall and a noble metal nanoparticle layer disposed on the tubular internal wall and contacted with a desired testing matter. The waveguide component is made of a light transmitting material for guiding the incident light to have an interaction with the noble metal nanoparticle layer. The photon detector detects an emergent light exiting the waveguide component after the interaction of the noble metal nanoparticle layer with the desired testing matter. The system further includes a first optical fiber installed between the light source and the waveguide component for transmitting the incident light to the waveguide component, a lens and a second optical fiber. The lens collects and transmits the emergent light to the photon detector through the second optical fiber.

Abstract: A method and an apparatus for detection of a bioparticle by single-bead based DEP. The method includes the steps of immobilizing a single DEP bead in one electric field; immobilizing a first bio-recognizing molecule on the single DEP bead; intromitting at least one target bioparticle into the electric field for binding the first bio-recognizing molecule, whereby the target bioparticle and the first bio-recognizing molecule are bound with each other to form a complex molecule; and detecting the complex molecule by a detection device. The apparatus is composed of a chip, a power source, a single DEP bead, and a detection device.

Abstract: A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a generated electric field, ions having polarity reverse to that of an electrolytic solution will migrate to the surface of the microstructure to form a field-induced electrical double layer to result in electro-osmotic flows at the corners at two sides of the microstructure, which causes formation of relatively fierce circular vortices in the solution. A sensing system and a sensing method using the microfluidic device with microstructure are also disclosed.

Abstract: A bio-sensing system comprises a light source, a bio-sensing apparatus, a detecting platform, and a processing unit. A bio-sensing apparatus further comprising a substrate, a sample with at least one analyte, at least one grating bound on the substrate for diffracting a light beam in a reflection mode and outputting at least one output light beam, a plurality of nanoparticles being bound on one side of the grating, a molecular recognition unit bound on said nanoparticle surface, and a cover plate covering the nanoparticle-modified side of the substrate. The detecting platform receives a signal while the at least one output light beam passing through the bio-sensing apparatus. The processing unit couples with the detecting platform for receiving and analyzing the signal.

Abstract: A surface plasmon resonance sensing system and method thereof are disclosed. The system comprises an incident light source, a sensing element, a noble metal nanoparticle layer, a sample loading unit, and a light detector. The noble metal nanoparticle layer is composed of one of noble metal nanoballs, noble metal nanorods and noble metal nanoshells. The noble metal nanoparticle layer is disposed on the sensing element. The sample loading unit is used to allow a sample to be contacted with the noble metal nanoparticle layer. The light detector is used to detect an emergent light of the sensing element.

Abstract: This invention discloses a sensing apparatus with noble metal and sensing system and its method. The sensing apparatus with noble metal comprises a planar waveguide, a noble metal nano-particle layer, and a cover. The planar waveguide has a top plane. The noble metal nano-particle layer is uniformly distributed on the top plane of the planar waveguide. The cover has a notch, and is covered on the top plane of the planar waveguide to form a space between the notch and the top plane. Accordingly, a plurality of incident lights are led into the sensing apparatus with noble metal nano-particle to detect a testing substance contained in the aforesaid space.

Abstract: A surface plasmon resonance sensing system and method thereof are disclosed. The system comprises an incident light source, a sensing element, a noble metal nanoparticle layer, a sample loading unit, and a light detector. The noble metal nanoparticle layer is composed of one of noble metal nanoballs, noble metal nanorods and noble metal nanoshells. The noble metal nanoparticle layer is disposed on the sensing element. The sample loading unit is used to allow a sample to be contacted with the noble metal nanoparticle layer. The light detector is used to detect an emergent light of the sensing element.

Abstract: A surface plasmon resonance sensing system comprised of an incidence illuminant, a modified optical fiber, a layer of gold nanoparticles, a micro-fluidic module, and an illuminant detector; the modified optical fiber related to an optical fiber stripped off a portion of its protection layer and a cladding layer; the layer of noble metal nanoparticles covering over the modified optical fiber; the micro-fluidic module related to a micro-fluidic chip for containing the modified optical fiber and a sample; and the illuminant detector operating to detect the light emitted from the modified optical fiber.

Abstract: A method of measuring calcium ions is disclosed wherein a calcium sensitive reagent, calcichrome, is immobilized on a porour polymer film. The reaction of the calcium sensitive reagent to the Ca(II) is then measured and concentration determined as a function of the reaction.