Patents by Inventor Laia Elías Rius

Laia Elías Rius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of abacavir
    Patent number: 8183370
    Abstract: Process for removal of the amino protective group of a N-acylated {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R?H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: May 22, 2012
    Assignee: Esteve Quimica, SA
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Process for the preparation of abacavir
    Patent number: 8097723
    Abstract: Process for the preparation of abacavir, or its salts or its solvates comprising the step of reacting a compound (IV) where R1 is a (C1-C4)-alkyl radical with anhydrous hydrochloric acid/(C1-C6)-alcohol, and then with tri(C1-C4)-alkyl orthoformate, in the absence of water. The preparation process may include further steps of reacting the compound obtained with cyclopropylamine and subsequently hydrolysis to yield abacavir.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: January 17, 2012
    Assignee: Esteve Quimica, S.A.
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Process for the preparation of abacavir
    Publication number: 20100041883
    Abstract: Process for the preparation of abacavir, or its salts or its solvates comprising the step of reacting a compound (IV) where R1 is a (C1-C4)-alkyl radical with anhydrous hydrochloric acid/(C1-C6)-alcohol, and then with tri(C1-C4)-alkyl orthoformate, in the absence of water. The preparation process may include further steps of reacting the compound obtained with cyclopropylamine and subsequently hydrolysis to yield abacavir.
    Type: Application
    Filed: December 20, 2007
    Publication date: February 18, 2010
    Applicant: ESTEVE QUÍMICA, S.A.
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
  • Process for the Preparation of Abacavir
    Publication number: 20100004446
    Abstract: Process for removal of the amino protective group of a N-acylated [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl]methanol of formula (II) where R?H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.
    Type: Application
    Filed: September 27, 2007
    Publication date: January 7, 2010
    Applicant: ESTEVE QUÍMICA, S.A.
    Inventors: Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó