Patents by Inventor Larry L. Hench
Larry L. Hench has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9388074Abstract: Processes and methods of making and preparing, compositions and structural products therefrom are provided, whereby the surface area of alumino-silicate based powders is greatly increased and rendered chemically active so that when the functionalized powders are mixed with water poly-condensation reactions occur between the surfaces binding the powders together to form a structural material with negligible emission of carbon compounds. In another embodiment, the surface functionalized powders can be mixed with an additive; a dry aggregate, such as sand and water to make a slurry that can be poured or cast into any desired shape and rapidly cured to a hardened shape suitable for use as a structural material with the mechanical strength equivalent to Portland-cement based concrete products.Type: GrantFiled: December 16, 2008Date of Patent: July 12, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventors: Sudipta Seal, Larry L. Hench, Suresh Babu Krishna Moorthy, David Reid, Ajay Karakoti
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Patent number: 8404609Abstract: A method of forming functionalized fly ash particles includes contacting a plurality of fly ash particles with a hydroxide compound under conditions to directly bond oxygen (O) onto a surface portion of the plurality of fly ash particles. The plurality of fly ash particles having O directly bound to their surface portion are reacted with an organic alcohol or an organic acid to covalently bond hydrophobic groups in the form of condensation residue from the organic alcohol or organic acid to the O to form the plurality of functionalized fly ash particles.Type: GrantFiled: October 19, 2012Date of Patent: March 26, 2013Assignee: University of Central Florida Research Foundation, Inc.Inventors: Sudipta Seal, David L. Reid, Larry L. Hench
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Patent number: 8318625Abstract: A method of scavenging oil from an oil-water mixture includes providing a plurality of functionalized fly ash particles having functionalized surfaces including reactive groups or reactive materials having hydrophobic groups covalently bound to the reactive groups or reactive materials. The oil-water mixture is contacted with the plurality of functionalized fly ash particles. The plurality of functionalized fly ash particles absorb oil from the oil-water mixture to form oil-laden fly ash particles. The oil-laden fly ash particles can be fed into a combustion process to generate heat from oil absorbed thereon, or absorbed oil from the oil-laden fly ash particles can be separated using a desorption process, and the oil recovered after separating.Type: GrantFiled: July 11, 2011Date of Patent: November 27, 2012Assignee: University of Central Florida Research Foundation, Inc.Inventors: Sudipta Seal, David L. Reid, Larry L. Hench
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Publication number: 20120006753Abstract: A method of scavenging oil from an oil-water mixture includes providing a plurality of functionalized fly ash particles having functionalized surfaces including reactive groups or reactive materials having hydrophobic groups covalently bound to the reactive groups or reactive materials. The oil-water mixture is contacted with the plurality of functionalized fly ash particles. The plurality of functionalized fly ash particles absorb oil from the oil-water mixture to form oil-laden fly ash particles. The oil-laden fly ash particles can be fed into a combustion process to generate heat from oil absorbed thereon, or absorbed oil from the oil-laden fly ash particles can be separated using a desorption process, and the oil recovered after separating.Type: ApplicationFiled: July 11, 2011Publication date: January 12, 2012Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Sudipta Seal, David L. Reid, Larry L. Hench
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Publication number: 20110163472Abstract: A process for making foamed glasses and ceramics from sol-gels is disclosed. The method includes preparing a mixture of reactants capable of forming a sol-gel with addition of a catalyst to control the condensation stage followed by foaming using vigorous agitation in the presence of surfactants. The gelled bodies are aged, dried, and thermally stabilized to obtain a consolidated macroporous material. The resulting structure comprises a three-dimensional network of spherical open pores that are thoroughly interconnected. The process may involve sol-gel systems using a mixture of metal alkoxides, and may produce glasses in unary systems (SiO2), binary systems (70% mol SiO2-30% mol CaO), and ternary systems (60% mol SiO2, 36% mol CaO, 4% mol P2O5). The macro-porous material has pores in the 10-500 ?m range and has potential for use as matrix in tissue engineering, in bone repair, and in organ regeneration.Type: ApplicationFiled: January 5, 2011Publication date: July 7, 2011Inventors: Pilar Sepulveda, Larry L. Hench
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Publication number: 20110112272Abstract: Processes and methods of making and preparing, compositions and structural products therefrom are provided, whereby the surface area of alumino-silicate based powders is greatly increased and rendered chemically active so that when the functionalized powders are mixed with water poly-condensation reactions occur between the surfaces binding the powders together to form a structural material with negligible emission of carbon compounds. In another embodiment, the surface functionalized powders can be mixed with an additive; a dry aggregate, such as sand and water to make a slurry that can be poured or cast into any desired shape and rapidly cured to a hardened shape suitable for use as a structural material with the mechanical strength equivalent to Portland-cement based concrete products.Type: ApplicationFiled: December 16, 2008Publication date: May 12, 2011Applicant: University of Central Florida Research Foundation, Inc.Inventors: Sudipta Seal, Larry L. Hench, Suresh Babu Krishna Moorthy, David Reid, Ajay Karakoti
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Publication number: 20080176190Abstract: The present invention relates to the use of a bioactive glass as an air abrasive agent for use in the treatment of dental disorders.Type: ApplicationFiled: December 18, 2007Publication date: July 24, 2008Inventors: Richard J. Cook, Timothy F. Watson, Larry L. Hench, Ian D. Thompson
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Patent number: 7329126Abstract: Bioactive glasses may be used as air abrasive agents in methods for treating or preventing dental hard tissue and pulpal disorders, such as dental pain.Type: GrantFiled: March 29, 2002Date of Patent: February 12, 2008Assignees: King's College London Strand, Imperial College Innovations LimitedInventors: Richard J. Cook, Timothy F. Watson, Larry L. Hench, Ian D. Thompson
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Patent number: 7040960Abstract: The present invention relates to a method of cutting a bioactive glass object which comprises contacting the bioactive glass object with bioactive glass particles delivered using an air abrasion system.Type: GrantFiled: March 28, 2002Date of Patent: May 9, 2006Assignees: King's College London, Imperial College Innovations LimitedInventors: Larry L. Hench, Ian D. Thompson, Richard J. Cook, Timothy F. Watson, Paul D. Robinson
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Publication number: 20040241238Abstract: A process for making foamed glasses and ceramics from sol-gels is disclosed. The method includes preparing a mixture of reactants capable of forming a sol-gel with addition of a catalyst to control the condensation stage followed by foaming using vigorous agitation in the presence of surfactants. The gelled bodies are aged, dried, and thermally stabilized to obtain a consolidated macroporous material. The resulting structure comprises a three-dimensional network of spherical open pores that are thoroughly interconnected. The process may involve sol-gel systems using a mixture of metal alkoxides, and may produce glasses in unary systems (SiO2), binary systems (70% mol SiO2-30% mol CaO), and ternary systems (60% mol SiO2, 36% mol CaO, 4% mol P2O5). The macro-porous material has pores in the 10-500 &mgr;m range and has potential for use as matrix in tissue engineering, in bone repair, and in organ regeneration.Type: ApplicationFiled: July 7, 2004Publication date: December 2, 2004Inventors: Pilar Sepulveda, Larry L Hench
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Publication number: 20040137827Abstract: The present invention relates to a method of cutting a bioactive glass object which comprises contacting the bioactive glass object with bioactive glass particles delivered using an air abrasion system.Type: ApplicationFiled: March 11, 2004Publication date: July 15, 2004Inventors: Larry L Hench, Ian D Thompson, Richard J Cook, Timothy F Watson, Paul D Robinson
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Publication number: 20040009598Abstract: Compositions comprising bioactive glass compositions or extracts thereof which include ions in an appropriate concentration and ratio that they enhance osteoblast production, and methods of preparation and use thereof, are disclosed. The compositions can be included in implantable devices that are capable of inducing tissue formation in autogeneic, allogeneic and xenogeneic implants, for example as coatings and/or matrix materials. Examples of such devices include prosthetic implants, sutures, stents, screws, plates, tubes, and the like. Aqueous extracts of the bioactive glass compositions, which extracts are capable of stimulating osteoblast production, are also disclosed.Type: ApplicationFiled: July 7, 2003Publication date: January 15, 2004Inventors: Larry L Hench, Julia M Polak, Lee D.k. Buttery, Ioannis D Xynos, Jason Maroothynaden
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Publication number: 20030008263Abstract: The present invention relates to the use of a bioactive glass as an air abrasive agent for use in the treatment of dental disorders.Type: ApplicationFiled: March 29, 2002Publication date: January 9, 2003Applicant: King's College London of StrandInventors: Richard J. Cook, Timothy F. Watson, Larry L. Hench, Ian D. Thompson
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Patent number: 6482444Abstract: Silver-containing, sol-gel derived bioactive glass compositions and methods of preparation and use thereof are disclosed. The compositions can be in the form of particles, fibers and/or coatings, among other possible forms, and can be used, for example, for treating wounds, improving the success of skin grafts, reducing the inflammatory response and providing anti-bacterial treatments to a patient in need thereof. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating the compositions into or onto the implanted materials. The compositions can also be used to prepare devices used for in vitro and ex vivo cell culture.Type: GrantFiled: June 14, 2000Date of Patent: November 19, 2002Assignee: Imperial College InnovationsInventors: Maria Bellantone, Nichola J. Coleman, Larry L. Hench
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Patent number: 6299930Abstract: Percutaneous implants are disclosed including a portion implantable into a patient, a dermal bonding region capable of forming a bond between the implant and a dermal layer of the patient after the implantable portion is implanted into the patient, and the dermal bonding region including a substrate with a discontinuous coating of particulate bioactive glass wherein the average spacing between the particles of bioactive glass is predetermined and at least about 20 microns prior to implantation into the patient. Also disclosed are bioactive coatings including a substrate and fibers and/or particles of bioactive glass distributed on the substrate with a predetermined average interfiber distance of at least about 20 microns.Type: GrantFiled: September 20, 1999Date of Patent: October 9, 2001Assignees: USBiomaterials Corp., University of Florida Research Foundation, Inc.Inventors: James S. Marotta, Guy LaTorre, Christopher Batich, Larry L. Hench
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Patent number: 6190684Abstract: The present invention relates to injectable suspensions of bio-active glass and dextran or a dextran derivative for the repair of soft tissue or hard bone in mammals, especially humans. In one embodiment, the dextran derivatives include free radical polymerizable groups, which can be polymerized following injection into a patient.Type: GrantFiled: November 23, 1998Date of Patent: February 20, 2001Assignee: University of Florida Research Foundation, Inc.Inventors: Larry L. Hench, Jon K. West, Guy LaTorre, June Wilson, William Toreki, III, Christopher Batich
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Patent number: 6051247Abstract: A moldable bioactive composition including (a) bioactive particles of bioactive glass, glass-ceramics, calcium phosphates, calcium apatites, or mixtures thereof; and (b) a biodegradable polysaccharide carrier including a polysaccharide with an average molecular weight of about 200,000-5,000,000.Type: GrantFiled: July 10, 1998Date of Patent: April 18, 2000Assignee: University of Florida Research Foundation, Inc.Inventors: Larry L. Hench, Guy LaTorre, Jon K. West, June Wilson, William Toreki, III, Christopher Batich
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Patent number: 5990380Abstract: Percutaneous implants are disclosed including a portion implantable into a patient, a dermal bonding region capable of forming a bond between the implant and a dermal layer of the patient after the implantable portion is implanted into the patient, and the dermal bonding region including a substrate with a discontinuous coating of particulate bioactive glass wherein the average spacing between the particles of bioactive glass is predetermined and at least about 20 microns prior to implantation into the patient. Also disclosed are bioactive coatings including a substrate and fibers and/or particles of bioactive glass distributed on the substrate with a predetermined average interfiber distance of at least about 20 microns.Type: GrantFiled: October 10, 1997Date of Patent: November 23, 1999Assignees: University of Florida Research Foundation, Inc., USBiomaterials, Inc.Inventors: James S. Marotta, Guy LaTorre, Christopher Batich, Larry L. Hench
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Patent number: 5981412Abstract: A bioactive ceramic composition including 47 to 51% SiO.sub.2, 23 to 25% CaO, 23 to 25% Na.sub.2 O and 0 to 6% P.sub.2 O.sub.5, the bioactive ceramic having a bioacitivity level such that the composition forms at least a thin layer of HCA within about 30 hours of implantation into a patient. The bioactive ceramic composition having a crystallinity of 34 to 60 volume percent and a crystalline phase of 1Na.sub.2 O.2CaO.3SiO.sub.2.Type: GrantFiled: May 1, 1997Date of Patent: November 9, 1999Assignee: University of Florida Research FoundationInventors: Larry L. Hench, Guy La Torre, Oscar P. Filho, Edgar Zanotto
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Patent number: 5962549Abstract: Composites suitable for use as prostheses for attachment to soft tissues, such as cartilage, tendons, skin, tympanic membrane and gingiva, as well as to cancellous or trabecular bone, are based on combination of a polyolefinic binder with certain bioactive glass materials. The composites bond actively with soft tissues and are readily formulated achieve mechanical properties comparable to those of the soft tissue of interest.Type: GrantFiled: December 9, 1997Date of Patent: October 5, 1999Assignees: University of London, University of Florida Research FoundationInventors: William Bonfield, Min Wang, Larry L. Hench