Patents by Inventor Lars Kongsbak
Lars Kongsbak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10400288Abstract: The present application concerns a new in vitro method for assessing the risk that a subject suffers from prostate cancer.Type: GrantFiled: February 5, 2016Date of Patent: September 3, 2019Assignees: Aarhus Universitet, Region Midtjylland, QIAGEN GmbHInventors: Anni Rønfeldt Thomsen, Jacob Christian Fredsøe, Karina Dalsgaard Sørensen, Lars Kongsbak, Peter Mouritzen, Torben Ørntoft
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Patent number: 10358681Abstract: The present application concerns a new in vitro method for assessing the prognosis of a prostate cancer patient, comprising measuring the expression level of at least two miRs selected from group of miRs consisting of: miR-106a-5p, miR-10b-5p, miR-133a-3p, mi R-152-3p, miR-185-5p, miR-193a-5p, miR-221-3p, miR-23a-3p, miR-30d-3p, miR-326, mi R-374b-5p, miR-615-3p and mi R-625-3p in a RNA sample from prostate cells obtained from said patient, wherein a changed expression level of said at least 2 miRs, as compared to a reference expression profile, is indicative of the prognosis of said prostate cancer patient.Type: GrantFiled: February 26, 2016Date of Patent: July 23, 2019Assignees: Aarhus Universitet, Region Midtjylland, QIAGEN GmbHInventors: Anni Rønfeldt Thomsen, Helle Kristensen, Karina Dalsgaard Sørensen, Lars Kongsbak, Peter Mouritzen, Torben Ørntoft
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Publication number: 20180044737Abstract: The present application concerns a new in vitro method for assessing the prognosis of a prostate cancer patient, comprising measuring the expression level of at least two miRs selected from group of miRs consisting of: miR-106a-5p, miR-10b-5p, miR-133a-3p, miR-152-3p, miR-185-5p, miR-193a-5p, miR-221-3p, miR-23a-3p, miR-30d-3p, miR-326, miR-374b-5p, miR-615-3p and miR-625-3p in a RNA sample from prostate cells obtained from said patient, wherein a changed expression level of said at least 2 miRs, as compared to a reference expression profile, is indicative of the prognosis of said prostate cancer patient.Type: ApplicationFiled: February 26, 2016Publication date: February 15, 2018Applicant: Exiqon A/SInventors: Anni RØNFELDT THOMSEN, Helle KRISTENSEN, Karina DALSGAARD SØRENSEN, Lars KONGSBAK, Peter MOURITZEN, Torben ØRNTOFT
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Publication number: 20180030542Abstract: The present application concerns a new in vitro method for assessing the risk that a subject suffers from prostate cancer.Type: ApplicationFiled: February 5, 2016Publication date: February 1, 2018Inventors: Anni RØNFELDT THOMSEN, Jacob Christian FREDSØE, Karina DALSGAARD SØRENSEN, Lars KONGSBAK, Peter MOURITZEN, Torben ØRNTOFT
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Publication number: 20170017820Abstract: A computing system may receive an encoded representation of a biological sample. The encoded representation may contain an embedded barcode, and the computing system may include locked features. Possibly based on the embedded barcode, the computing system may automatically select a data processing pipeline for the encoded representation. Also possibly based on the embedded barcode, the computing system may unlock one or more of the locked features. The computing system may process the encoded representation in the selected data processing pipeline and according to the one or more unlocked features.Type: ApplicationFiled: July 14, 2015Publication date: January 19, 2017Inventor: Lars Kongsbak
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Patent number: 8383344Abstract: The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.Type: GrantFiled: June 1, 2009Date of Patent: February 26, 2013Assignee: Exiqon A/SInventors: Nana Jacobsen, Lars Kongsbak, Sakari Kauppinen, Søren Morgenthaler Echwald, Peter Mouritzen, Peter Stein Nielsen, Mikkel Nørholm
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Patent number: 8192937Abstract: The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.Type: GrantFiled: April 7, 2005Date of Patent: June 5, 2012Assignee: Exiqon A/SInventors: Nana Jacobsen, Lars Kongsbak, Sakari Kauppinen, Søren Morgenthaler Echwald, Peter Mouritzen, Peter Stein Nielsen, Mikkel Nørholm
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Publication number: 20110076675Abstract: The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.Type: ApplicationFiled: June 1, 2009Publication date: March 31, 2011Applicant: EXIQON A/SInventors: Nana Jacobsen, Lars Kongsbak, Sakari Kauppinen, Søren Morgenthaler Echwald, Peter Mouritzen, Peter Stein Nielsen, Mikkel Nørholm
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Patent number: 7314915Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.Type: GrantFiled: September 23, 2004Date of Patent: January 1, 2008Assignee: Fisher BioImage APSInventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
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Publication number: 20070232542Abstract: A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.Type: ApplicationFiled: May 30, 2007Publication date: October 4, 2007Applicant: Novo Nordisk A/SInventors: Lars Kongsbak, Niels Bergenhem, Lars Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
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Patent number: 7273745Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: GrantFiled: November 28, 2006Date of Patent: September 25, 2007Assignee: Novozymes A/SInventors: Lene Nonboe Andersen, Hanne Dela, legal representative, Niels Erik Krebs Lange, Mads Eskelund Bjørnvad, Søren Møller, Sanne O. Schrøder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak, Martin Schülein, deceased
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Publication number: 20070116744Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: ApplicationFiled: November 28, 2006Publication date: May 24, 2007Applicant: Novozymes A/SInventors: Lene Andersen, Martin Schulein, Niels Lange, Mads Bjornvad, Soren Moller, Sanne O Glad, Markus Kauppinen, Kirk Schnorr, Lars Kongsbak
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Patent number: 7144722Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236–242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: GrantFiled: September 4, 2003Date of Patent: December 5, 2006Assignee: Novozymes A/SInventors: Lene Nonboe Andersen, Hanne Dela, legal representative, Niels Erik Krebs Lange, Mads Eskelund Bjornvad, Soren Moller, Sanne O Schroder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak, Martin Schulein, deceased
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Publication number: 20050272075Abstract: The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.Type: ApplicationFiled: April 7, 2005Publication date: December 8, 2005Inventors: Nana Jacobsen, Lars Kongsbak, Sakari Kauppinen, Soren Echwald, Peter Mouritzen, Peter Nielsen, Mikkel Norholm
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Publication number: 20050245449Abstract: A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.Type: ApplicationFiled: July 6, 2005Publication date: November 3, 2005Applicant: Novo Nordisk, A/SInventors: Lars Kongsbak, Niels Bergenhem, Lars Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
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Patent number: 6818443Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.Type: GrantFiled: June 1, 2001Date of Patent: November 16, 2004Assignee: BioImage A/SInventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
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Publication number: 20040067572Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: ApplicationFiled: September 4, 2003Publication date: April 8, 2004Applicant: Novozymes A/SInventors: Lene Nonboe Andersen, Martin Schulein, Hanne Dela, Niels Erik Krebs Lange, Mads Eskelund Bjornvad, Soren Moller, Sanne O Schroder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak
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Patent number: 6677147Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: GrantFiled: February 7, 2002Date of Patent: January 13, 2004Assignee: Novozymes A/SInventors: Lene Nonboe Andersen, Martin Schülein, Niels Erik Krebs Lange, Mads Eskelund Bjørnvad, Søren Møller, Sanne O. Schroder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak
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Patent number: 6630342Abstract: The present invention provides methods for high-temperature biopreparation of cellulosic fibers by contacting the fibers with pectin-degrading enzymes, preferably thermostable, alkaline, divalent cation-independent pectate lyases, under conditions compatible with scouring and bleaching technologies.Type: GrantFiled: February 20, 2001Date of Patent: October 7, 2003Assignee: Novozymes A/SInventors: Niels Erik Krebs Lange, Lars Kongsbak, Martin Shülein, Mads Eskelund Bjørnvad, Philip Anwar Husain
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Patent number: 6613528Abstract: The invention relates to a ellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.Type: GrantFiled: May 20, 2002Date of Patent: September 2, 2003Assignee: Novozymes A/SInventors: William Helbert, Henri Dominique Chanzy, Steffen Ernst, Martin Schulein, Tommy Lykke Husum, Lars Kongsbak