Patents by Inventor Lars Kongsbak

Lars Kongsbak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030152927
    Abstract: The invention relates to novel analysis slides or substrates with a closed configuration. The slides may be used for any application which normally utilizes a conventional microscope slide and can be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide. In particular, the invention provides closed slides for covalent immobilization of polypeptides and nucleic acids. Further provided are methods for carrying out biological assays using arrays of biomolecules immobilized on the slides of the invention. The arrays of the invention are comprised of a unique meandering or straight channel design as compared to the rectangular design of conventional arrays.
    Type: Application
    Filed: October 25, 2001
    Publication date: August 14, 2003
    Inventors: Mogens Havsteen Jakobsen, Lars Kongsbak
  • Publication number: 20030138969
    Abstract: The invention relates to novel analysis slides or substrates with a closed configuration. The slides may be used for any application which normally utilizes a conventional microscope slide and can be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide. In particular, the invention provides closed slides for covalent immobilization of polypeptides and nucleic acids. Further provided are methods for carrying out biological assays using arrays of biomolecules immobilized on the slides of the invention. The arrays of the invention are comprised of a unique meandering or straight channel design as compared to the rectangular design of conventional arrays.
    Type: Application
    Filed: January 24, 2002
    Publication date: July 24, 2003
    Inventors: Mogens Havsteen Jakobsen, Lars Kongsbak
  • Patent number: 6566083
    Abstract: The present invention relates to a method of detecting biologically active substances affecting intracellular processes, an isolated DNA, a vector and a cell for use in the method. More specifically, the present invention provides a method for detecting a biologically active substance that affects intracellular processes mediated through a protein kinase or a second messenger, which comprises incubating a cell with a test substance and measuring any change caused by the test substance in the flourescence of (i) a wild-type or modified green flourescent protein (GFP) having a protein kinase recognition site, (ii) a modified GFP containing a second messenger binding domain, or (iii) a hybrid polypeptide having a wild-type or modified GFP and an attached protein kinase recognition site or a second messenger binding domain.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: May 20, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
  • Publication number: 20030087415
    Abstract: The present invention relates to transformed bacterial hosts capable of expressing a pectate lyase enzyme endogenous to a strain of Thermotoga maritima, especially a Bacillus or E. coli host cell, is useful in a method for producing the Thermotoga maritima pectate lyase. The Thermotoga maritima pectate lyase is useful for industrial use, e.g. for treatment of textiles.
    Type: Application
    Filed: April 12, 2001
    Publication date: May 8, 2003
    Applicant: Novozymes A/S
    Inventors: Jens Toenne Andersen, Lars Kongsbak, Martin Schulein, Mads Eskelund Bjornvad
  • Publication number: 20030077609
    Abstract: Chimeric oligonucleotides are provided that contain non-modified DNA or RNA residues and modified nucleic acid residues. A modified nucleic acid residue is placed in the −1 position of the 3′ and/or 5′ end of the oligonucleotide. The oligonucleotides can exhibit significantly enhanced hybridization properties and improved capabilities as primers in nucleic acid extension and amplification reactions.
    Type: Application
    Filed: March 25, 2002
    Publication date: April 24, 2003
    Inventors: Mogens Havsteen Jakobsen, Henrik M. Pfundheller, Lars Kongsbak
  • Publication number: 20030049707
    Abstract: The invention relates to a ellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.
    Type: Application
    Filed: May 20, 2002
    Publication date: March 13, 2003
    Applicant: Novozymes A/S
    Inventors: William Helbert, Martin Schulein, Hanne Dela, Henri Dominique Chanzy, Steffen Ernst, Tommy Lykke Husum, Lars Kongsbak
  • Publication number: 20030040481
    Abstract: A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
    Type: Application
    Filed: September 6, 2002
    Publication date: February 27, 2003
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Christian Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
  • Publication number: 20020187485
    Abstract: The invention relates to novel analysis slides or substrates of the open configuration. The slides may be used for any application which normally utilizes a conventional microscope slide and can be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide. In particular, the invention provides open slides for covalent immobilization of polypeptides and nucleic acids. Further provided are methods for carrying out biological assays using arrays of biomolecules immobilized on the slides of the invention.
    Type: Application
    Filed: October 25, 2001
    Publication date: December 12, 2002
    Inventors: Mogens Hausteen Jakobsen, Lars Kongsbak
  • Patent number: 6461610
    Abstract: The present invention provides methods for modifying the motility of tissue factor (TF)-expressing cells, which are carried out by contacting such cells with an effective amount of Factor VIIai Factor VIIa agonist.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: October 8, 2002
    Assignee: Novo Nordisk A/S
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Christian Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
  • Publication number: 20020142438
    Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
    Type: Application
    Filed: February 7, 2002
    Publication date: October 3, 2002
    Applicant: Novozymes A/S
    Inventors: Lene Nonboe Andersen, Martin Schulein, Hanne Dela, Niels Erik Krebs Lange, Mads Eskelund Bjornvad, Soren Moller, Sanne O. Schroder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak
  • Publication number: 20020115194
    Abstract: The present invention provides methods for high-temperature biopreparation of cellulosic fibers by contacting the fibers with pectin-degrading enzymes, preferably thermostable, alkaline, divalent cation-independent pectate lyases, under conditions compatible with scouring and bleaching technologies.
    Type: Application
    Filed: February 20, 2001
    Publication date: August 22, 2002
    Applicant: Novozymes A/S
    Inventors: Niel Erik Krebs Lange, Lars Kongsbak, Martin Shulein, Mads Eskelund Bjornvad, Philip Anwar Husain
  • Publication number: 20020107362
    Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.
    Type: Application
    Filed: June 1, 2001
    Publication date: August 8, 2002
    Applicant: BIOIMAGE A/S
    Inventors: Ole Thastrup, Soren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjorn
  • Patent number: 6426189
    Abstract: The invention relates to a cellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: July 30, 2002
    Assignee: Novozymes A/S
    Inventors: William Helbert, Henri Dominique Chanzy, Steffen Ernst, Martin Schulein, Tommy Lykke Husum, Lars Kongsbak
  • Patent number: 6399351
    Abstract: A novel pectate lyase belonging to a novel family of polysaccharide lyases has good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: June 4, 2002
    Assignee: Novozymes A/S
    Inventors: Mads Eskelund Bjørnvad, Jens Toenne Andersen, Kirk Schnorr, Martin Schülein, Lars Kongsbak
  • Patent number: 6368843
    Abstract: A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: April 9, 2002
    Assignee: Novozymes A/S
    Inventors: Lene Nonboe Andersen, Martin Schülein, Niels Erik Krebs Lange, Mads Eskelund Bjørnvad, Søren Møller, Sanne O. Schrøder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak
  • Patent number: 6268163
    Abstract: The present invention provides methods for identifying candidate drugs that modulate factor VIIa-mediated intracellular signaling by measuring the effects of such drugs on the activation of the mitogen-activated protein kinase (MAP kinase) signaling pathway.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: July 31, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Christian Petersen, Ole Thastrup, Don Foster
  • Patent number: 6258590
    Abstract: The present invention provides methods for higha-temperature biopreparation of cellulosic fibers by contacting the fibers with pectin-degrading enzymes, preferably thermostable, alkaline, divalent cation-independent pectate lyases, under conditions compatible with scouring and bleaching technologies.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: July 10, 2001
    Assignees: Novozymes A/S, Novozymes North America
    Inventors: Niels Erik Krebs Lange, Lars Kongsbak, Martin Shülein, Mads Eskelund Bjørnvad, Philip Anwar Husain
  • Patent number: 6187580
    Abstract: A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase are derivable from Bacillus species.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: February 13, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Lene Nonboe Andersen, Martin Schülein, Niels Erik Krebs Lange, Mads Eskelund Bjørnvad, Søren Møller, Sanne O. Schrøder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak
  • Patent number: 6172188
    Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: January 9, 2001
    Inventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
  • Patent number: 5958713
    Abstract: The present invention provides a method for detecting a biologically active substance that affects intracellular processes mediated through a protein kinase or second messenger, which comprises incubating a cell with a test substance and measuring any change caused by the test substance in the fluorescence of (i) green fluorescent protein (GFP) having a protein kinase recognition site or (ii) GFP that has been modified to contain a second messenger binding domain.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: September 28, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Ole Thastrup, S.o slashed.ren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bj.o slashed.rn