Patents by Inventor Laszlo Nagy

Laszlo Nagy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6706762
    Abstract: In accordance with the present invention, it has been discovered that histone deacetylase associates with hormone receptor complexes and contributes to the repression thereof. It has further been discovered that exposure of a repressed system to histone deacetylase inhibitors relieves this repression, and that in combination with a ligand for a member the steroid/thyroid superfamily of receptors, the differentiation effects of retinoids are enhanced. Thus, histone deacetylase inhibitors have been found to be useful for the activation of genes responsive to hormone receptors and to conteract the oncogenic functions of oncogenic proteins. In accordance with another aspect of the invention, formulations useful for modulation of hormone-mediated processes have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes as well as methods of employing such compounds for the treatment of neoplastic diseases.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: March 16, 2004
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Richard J. Lin, Laszlo Nagy
  • Patent number: 6646008
    Abstract: In accordance with the present invention, it has been discovered that PPAR&ggr; is expressed consistently in tissues associated with each of a variety of disease states which result from neoplastic cell proliferation. It has further been discovered that maximal activation of PPAR&ggr; with exogenous ligand promotes terminal differentiation of primary cells which are otherwise subject to neoplastic cell proliferation. In accordance with another aspect of the invention, it has been discovered that RXR-specific ligands are also potent agents for induction of differentiation of cells expressing the PPAR&ggr;/RXR&agr; heterodimer, and that simultaneous treatment of cells subject to neoplastic cell proliferation with a PPAR&ggr;-selective ligand, in combination with an RXR-specific ligand, results in an additive stimulation of differentiation.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: November 11, 2003
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Peter Tontonoz, Laszlo Nagy
  • Publication number: 20020137794
    Abstract: In accordance with the present invention, it has been discovered that retinoic acid receptor (RAR) antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs (e.g., PPAR&agr;, PPAR&dgr; and PPAR&ggr;). Indeed, it has been discovered that RAR antagonists, in combination with agonists for members of the steroid/thyroid hormone receptor superfamily, are capable of inducing and/or enhancing processes mediated by such members.
    Type: Application
    Filed: July 13, 1999
    Publication date: September 26, 2002
    Inventors: RONALD M. EVANS, PETER J. TONTONOZ, LASZLO NAGY
  • Patent number: 6436993
    Abstract: In accordance with the present invention, it has been discovered that retinoic acid receptor (RAR) antagonists are capable of modulating processes mediated by other members of the steroid/thyroid hormone receptor superfamily, including permissive receptors such as PPARs (e.g., PPAR&agr;, PPAR&dgr; and PPAR&ggr;). Indeed, it has been discovered that RAR antagonists, in combination with agonists for members of the steroid/thyroid hormone receptor superfamily, are capable of inducing and/or enhancing processes mediated by such members.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: August 20, 2002
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Peter J. Tontonoz, Laszlo Nagy
  • Patent number: 6387673
    Abstract: In accordance with the present invention, it has been discovered that histone deacetylase associates with hormone receptor complexes and contributes to the repression thereof. It has further been discovered that exposure of a repressed system to histone deacetylase inhibitors relieves this repression. Thus, histone deacetylase inhibitors have been found to be useful for the activation of genes responsive to hormone receptors. In accordance with another aspect of the invention, formulations useful for modulation of hormone-mediated processes have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: May 14, 2002
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Laszlo Nagy
  • Patent number: 5397784
    Abstract: The invention relates to novel, parenterally useful, stable aqueous pharmaceutical compositions, mainly injectable solutions containing a bis-indole alkaloid. The compositions contain the zinc complex of a bis-indole alkaloid, preferably vincristine, vinblastine or 5'-nor-dihydrovinblastine together with a bivalent metal gluconate and a preserving agent dissolved in a mono- or polyhydric alcohol.The invention further relates to a process for the preparation of the above compositions.The composition according to the invention can be utilized for the parenteral administration of bis-indole alkaloids in the cancer chemotherapy.
    Type: Grant
    Filed: November 2, 1990
    Date of Patent: March 14, 1995
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Maria Gazdag, Gabor Szepesi, Takacsi Nagy, Szikla Z. Papp, Laszlo Nagy, Eva E. Kiss, Bobjak M. Zsoldos
  • Patent number: 5110720
    Abstract: The invention is directed to compositions for use in dental preparations which comprise an anti-osteoporotic agent, particularly ipriflavone, an anti-phlogistic agent, particularly triamcinolone, and, optionally, a natural or synthetic chemotherapeutic agent or local anaesthetic. The invention is also directed to methods for preparation of the compositions and methods of their use for treating caries and for the healing of acute, subacute or chronic inflammatory lesion of pulp, dental radix or the bony substance surrounding them.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: May 5, 1992
    Assignee: Reanal Einomvegyszergyar
    Inventors: Endre Csanyi, Gabor Csanyi, Tibor Balogh, Laszlo Nagy
  • Patent number: 5079406
    Abstract: A heating device in which a conventional voltage stabilizer having internal heat protection circuitry for limiting the heat which it will or can internally generate and having internal electrical short circuit protection means is employed to generate heat for transfer top heat transfer means. The heating device may be used in connection with automotive external rear view mirrors for removing fog, ice and/or water which condenses on the outer surface of the mirror.
    Type: Grant
    Filed: July 12, 1990
    Date of Patent: January 7, 1992
    Inventor: Laszlo Nagy
  • Patent number: 4679455
    Abstract: A step ratio power transmission provides a plurality of drive ratios between the input and output shafts. The power transmission, in addition to the input and output shafts, has a countershaft on which a plurality of ratio gears are rotatably mounted. The input shaft has at least one ratio gear rotatably mounted thereon while the output shaft has at least one gear secured thereto. A cluster gear is secured to either the input shaft or the output shaft while the other of these shafts has roatably mounted thereon one or more ratio gears. At least one of the ratio gears on the input shaft serves as an idler gear for one or more of the ratio gears on the countershaft.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: July 14, 1987
    Assignee: General Motors Corporation
    Inventor: Laszlo Nagy
  • Patent number: 4559278
    Abstract: The invention relates to a current inlet conductor assembly particularly for vacuum devices, especially for light sources such as incandescent lamps or discharge tubes, comprising an inlet conductor made of molybdenum for passing electric current and being surrounded by a vitreous material forming a hermetic seal therewith and an intermediate metal coating covering the surface of the inlet conductor at least on the places to be welded. The essence of the invention is that the intermediate metal coating is made of rhenium, advantageously with a thickness from 3 to 1200 nm. As proposed, the intermediate rhenium layer should be produced by electrolytic deposition, especially from an aqueous solution.
    Type: Grant
    Filed: September 19, 1983
    Date of Patent: December 17, 1985
    Assignee: Tungsram Reszvenytarsasag Abr. Tungsram Rt.
    Inventors: Janos Nagy, Laszlo Nagy, Endre Oldal
  • Patent number: 4539984
    Abstract: A respirator device especially for the respiratory treatment of new-born and inmate infants and for their adaptation to natural breathing. The device comprises oxygen and air ducts, means for adjusting the composition, temperature, humidity, and other parameters of the gas mixture, a patient junction, and pressure adjusting valve means coupled to the junction shunting the gas flow in the junction in such a way that the gas pressure is positive both during expiration and inspiration.The respiration demand of the patient is sensed by a means responsive to pressure drops which controls a starting signal generator and a beat generator. The beat generator controls the valve means. The device can be adjusted to controlled respiration, controlled assisted respiration, inspected and assisted respiration, and continuous positive airway pressure modes, whereby it can be adapted to various respiratory diseases.
    Type: Grant
    Filed: November 19, 1982
    Date of Patent: September 10, 1985
    Assignee: Vas es Moszeripari Szovetkezet
    Inventors: Janos Kiszel, Laszlo Papp, Laszlo Nagy
  • Patent number: 4539199
    Abstract: Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: September 3, 1985
    Assignee: Egyt Gyogyszervegyeszeti Gyar
    Inventors: Erno Orban, Janos Borvendeg, Laszlo Nagy, Marta Sotinee Tolvay, Erzsebet Bander
  • Patent number: 4439131
    Abstract: Concrete elements and a lifting mechanism are secured against tilting at the time of form removal, and the formwork is fixed in place. In the apparatus, a forming unit, a concreting unit and a form removal unit are provided. The forming unit has a single rigid form adapted to shape the bottom and the sides of the elements or products, is open on top and is assembled for use as required. The form removal unit has means for maintaining the product and the removal unit itself in a fixed position against tilting, as well as means for maintaining the formwork in a fixed position, and means for actuating them.
    Type: Grant
    Filed: February 11, 1982
    Date of Patent: March 27, 1984
    Assignee: Beton- es Vasbetonipari Muvek
    Inventors: Laszlo Nagy, Laszlo Papp, Laszlo Toth, Endre Jankovics, Zoltan Varnagy
  • Patent number: 4353702
    Abstract: A configuration for a sailboat mainsail comprises a rotating wind-mill like sail structure mounted on a rotating pedestal base. The wind driven rotating sail delivers power to the sailboat propeller through a flexible driveshaft and transmission and thus provides an ability to sail a particular desired course direction irrespective of the direction from which the wind is blowing.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: October 12, 1982
    Assignee: F M Machine Company
    Inventor: Laszlo Nagy
  • Patent number: 4341281
    Abstract: A split axle drive mechanism for a part-time four-wheel drive vehicle comprises an automotive type differential which has an input to the differential case and a pair of outputs from the respective side gears. One output is directly connected to its associated side gear so that the associated side gear is always drive connected to one selectively driven vehicle wheel. The other output includes a clutch which is disengaged in the two wheel drive mode (selected at the transfer case) so that the other selectively driven vehicle wheel does not back drive the other side gear. This reduces wear and power consumption in the two wheel drive mode.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: July 27, 1982
    Assignee: General Motors Corporation
    Inventor: Laszlo Nagy
  • Patent number: 4310549
    Abstract: 1-tert.-butylamino-3-(2,5-dichlorophenoxy)-2-propanol and its pharmaceutically acceptable acid addition salts possess hypotensive and bradycardizing effects. Thus they can be applied in human therapy for the treatment of hypertension and simultaneously also of tachycardia.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: January 12, 1982
    Inventors: Andor Hajos, Marton Fekete, Marianna Kurti, Tibor Lang, Lajos Toldy, Janos Borvendeg, Laszlo Nagy, Sandor Elek, Istvan Elekes, Istvan Polgari
  • Patent number: 4287194
    Abstract: A pharmaceutical compositions with hypotensive effects which comprise a compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof, ##STR1## wherein R.sup.1 is formula (II) ##STR2## wherein R.sup.4 and R.sup.5 each represent hydrogen, hydroxy, nitro at the same timeR.sup.2 and R.sup.3 are hydrogen, orR.sup.1 are 3-chloro-6-pyridazinylamino, 3-methyl-6-pyridazinylamino or 3-carbamoyl-6-pyridazinylamino, and at the same timeR.sup.2 and R.sup.3 form together formula (III), ##STR3## wherein R.sup.6 is C.sub.1-4 alkyl group,R.sup.7 is hydrogen or a C.sub.1-4 alkyl group, andn is an integer of 1 to 3, orR.sup.2 and R.sup.3 form together a group of the general formula (IV),=Q-R.sup.8 (IV)whereinQ is C.sub.5-7 cycloaliphatic, andR.sup.8 is hydrogen, a C.sub.1-4 alkoxycarbonyl or a C.sub.2-4 alkyl,and a compound of formula (V) or a pharmaceutically acceptable acid addition salt thereof, ##STR4## wherein R.sup.9 is naphthyl, 4-indolyl or 4-morpholino-1,2,5-thiadiazol-3-yl group or ##STR5## .
    Type: Grant
    Filed: July 6, 1979
    Date of Patent: September 1, 1981
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Kosa, Janos Borvendeg, Zsuzsanna Huszti, Judit Kosary, Geza Szilagyi, Laszlo Tardos, Endre Kasztreiner, Laszlo Nagy, Erzsebet Szuucs, Gabriella Kiss
  • Patent number: 4222283
    Abstract: A transmission having a gravity feed and centrifugal pressure lubricating system. Rotating drive and output gearing throws oil to a primary collector for gravity feed down in a first passage in the housing to a through-bore in the output shaft and for feed upward in a second passage to a blind bore in the input shaft. Rotating high-speed gearing throws oil to a secondary collector for gravity feed in a second passage to the blind bore and then to the through-bore. A plastic disk, having a central aperture smaller than the shaft bores, is fixed and sealed in a chamber between each passage and each bore end. A disk resiliently engages a plastic ferrule in each open bore end to seal the disk to the shaft end to permit gravity flow of oil through the central aperture into the bores and to retain an annular body of oil in the bores during shaft rotation and to centrifuge the oil through radial ports to lubricate the drive gear bearings.
    Type: Grant
    Filed: April 27, 1978
    Date of Patent: September 16, 1980
    Assignee: General Motors Corporation
    Inventor: Laszlo Nagy
  • Patent number: 4174644
    Abstract: A transmission having four forward gearsets and reverse gearing on one side of the forward gearsets. First and second shift members are mounted on the other side of the forward gearing for axial shifting movement to selectively engage the forward gearsets. A shift shaft having a shift lever is mounted transversely of the forward gearsets for axial selecting movement and rotary shifting movement. A reverse shift member is centrally pivotally mounted on the shift shaft, engages a guide to prevent axial movement, and has one end adjacent the other shift members and the other end shifting the reverse gearing.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: November 20, 1979
    Assignee: General Motors Corporation
    Inventors: Laszlo Nagy, Donald J. Pulk
  • Patent number: 4013335
    Abstract: An improved construction for a lamp cap suitable for interconnecting the elongated constricted neck of a halogen lamp to an electrode-bearing lamp holder is described. A hollow elongated deformable insert is coaxially positioned within a conventional cover disc of the lamp cap. The interior dimension of the insert is chosen to effect a secure frictional engagement with at least 30% of the length of the constricted lamp neck, and is permanently or removably affixed to the surrounding cover disc. The lamp holder may then be affixed to the composite lamp cap to complete the assembly.
    Type: Grant
    Filed: July 2, 1975
    Date of Patent: March 22, 1977
    Assignee: Egyesult Izzolampa Es. Villamossagi Resveny tarsasag
    Inventors: Laszlo Varkonyi, Gyorgy Szabo, Jozsef Orto, Laszlo Nagy, Janos Spielmann, Gyorgy Rabatin, Istvan Pozsonyi