Patents by Inventor Laura Brandolini

Laura Brandolini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
    Patent number: 12268671
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of chemotherapy-induced neuropathy, preferably in the treatment and/or prevention of chemotherapy-induced peripheral neuropathy (CIPN) or chemotherapy-induced optic neuropathy.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: April 8, 2025
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Laura Brandolini, Pier Adelchi Ruffini, Marcello Allegretti
  • IL-8 INIHIBITORS FOR USE IN THE TREATMENT OF SOME UROLOGICAL DISORDERS
    Publication number: 20250032461
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of interstitial cystitis/painful bladder syndrome (IC/PBS) and/or over active bladder (OAB), also including IC/PBS and/or OAB induced by anticancer therapy. Methods of treatment and/or prevention, combinations and kits comprising said IL-8 inhibitors are also covered therein.
    Type: Application
    Filed: October 17, 2024
    Publication date: January 30, 2025
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Maria Candida CESTA, Gianluca BIANCHINI, Laura BRANDOLINI, Patrizia ANGELICO
  • CO-CRYSTALS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20250025435
    Abstract: The present invention relates to new co-crystals of non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the class of phenylpropionic or phenylacetic acid derivatives. Lysine and Gabapentin, to their pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.
    Type: Application
    Filed: October 25, 2022
    Publication date: January 23, 2025
    Inventors: Andrea ARAMINI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI, Laura BRANDOLINI
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS
    Publication number: 20250009719
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.
    Type: Application
    Filed: September 23, 2024
    Publication date: January 9, 2025
    Inventors: Laura BRANDOLINI, Marcello Allegretti, Mauro Martins Teixeira
  • C5AR INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED IATROGENIC PAIN
    Publication number: 20240398731
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Application
    Filed: August 9, 2024
    Publication date: December 5, 2024
    Inventors: Laura BRANDOLINI, Thiago Mattar CUNHA, Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI
  • IL-8 inihibitors for use in the treatment of some urological disorders
    Patent number: 12150933
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of interstitial cystitis/painful bladder syndrome (IC/PBS) and/or over active bladder (OAB), also including IC/PBS and/or OAB induced by anticancer therapy. Methods of treatment and/or prevention, combinations and kits comprising said IL-8 inhibitors are also covered therein.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: November 26, 2024
    Assignee: DOMPÈ FARMACEUTICI S.P.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta, Gianluca Bianchini, Laura Brandolini, Patrizia Angelico
  • IL-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections
    Patent number: 12133843
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: November 5, 2024
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Laura Brandolini, Marcello Allegretti, Mauro Martins Teixeira
  • C5aR inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain
    Patent number: 12102607
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 1, 2024
    Assignee: Dompe' Farmaceutici S.P.A.
    Inventors: Laura Brandolini, Thiago Mattar Cunha, Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
  • C5AR1 INHIBITORS FOR TREATING HYPERSENSITIVITY REACTIONS TO TAXANES
    Publication number: 20240180888
    Abstract: The present invention relates to the use of a C5aR1 inhibitor for the prevention or treatment of a hypersensitivity reaction (HSR) to a taxane in an individual.
    Type: Application
    Filed: March 17, 2022
    Publication date: June 6, 2024
    Inventors: Marcello ALLEGRETTI, Andrea ARAMINI, Piergiorgio AMENDOLA, Laura BRANDOLINI, Maria Candida CESTA, Anna SIRICO
  • CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES
    Publication number: 20240156757
    Abstract: The present invention relates to a CXCL8 inhibitor and a pharmaceutical composition thereof, for use in the prevention or treatment of seizures.
    Type: Application
    Filed: March 3, 2022
    Publication date: May 16, 2024
    Inventors: Marcello ALLEGRETTI, Laura BRANDOLINI, Annamaria VEZZANI, Rossella DI SAPIA, Teresa RAVIZZA, Silvia Maria BALOSSO
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME SARCOMAS
    Publication number: 20230248704
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1 /CXCR2 receptor inhibitors, useful in the treatment and/or prevention of some sarcomas, preferably in the treatment and/or prevention of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or lung metastasis associated thereof.
    Type: Application
    Filed: April 17, 2023
    Publication date: August 10, 2023
    Inventors: Ryan David ROBERTS, Laura BRANDOLINI
  • SYNERGISTIC ADMIXTURES OF GABAPENTIN AND KETOPROFEN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE
    Publication number: 20230165820
    Abstract: The present invention relates to a synergistic admixture of Gabapentin and Ketoprofen, preferably Ketoprofen Lysine, to a pharmaceutical composition comprising said admixtures and to the use of said admixtures or pharmaceutical compositions in the treatment of acute or chronic pain, in particular in the treatment of neuropathic or inflammatory pain.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 1, 2023
    Inventors: Andrea ARAMINI, Marcello ALLEGRETTI, Gianluca BIANCHINI, Samuele LILLINI, Mara TOMASSETTI, Laura BRANDOLINI
  • IL-8 inhibitors for use in the treatment of some sarcomas
    Patent number: 11660291
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of some sarcomas, preferably in the treatment and/or prevention of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or lung metastasis associated thereof.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 30, 2023
    Assignees: Dompe' Farmaceutici S.P.A., Research Institute at Nationwide Children's Hospital
    Inventors: Ryan David Roberts, Laura Brandolini
  • CXCL8 (INTERLEUKIN-8) ACTIVITY INHIBITOR AND CORTICOSTEROID COMBINATION AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20230108050
    Abstract: The present invention relates to a combination of a CXCL8 activity inhibitor and a corticosteroid, and a pharmaceutical composition thereof, for use in the treatment of corticosteroid-insensitive asthma as well as to a method for treating corticosteroid-insensitive asthma by administration of said pharmaceutical composition.
    Type: Application
    Filed: February 18, 2021
    Publication date: April 6, 2023
    Inventors: Remo De Castro RUSSO, Mauro Martins TEIXEIRA, Marcello ALLEGRETTI, Laura BRANDOLINI
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME SARCOMAS
    Publication number: 20210361627
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of some sarcomas, preferably in the treatment and/or prevention of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or lung metastasis associated thereof.
    Type: Application
    Filed: October 23, 2018
    Publication date: November 25, 2021
    Inventors: Ryan David Roberts, Laura Brandolini
  • 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
    Patent number: 11046662
    Abstract: The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). The compounds of the invention are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: June 29, 2021
    Assignee: DOMPÉ FARMACEUTICI S.P.A.
    Inventors: Andrea Aramini, Gianluca Bianchini, Laura Brandolini, Andrea Beccari, Samuele Lillini, Giuseppe Nano
  • C5AR INHIBITORS FOR USE IN THE TREATMENT OF CHEMOTHERAPY-INDUCED IATROGENIC PAIN
    Publication number: 20200397725
    Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).
    Type: Application
    Filed: December 11, 2018
    Publication date: December 24, 2020
    Inventors: Laura Brandolini, Thiago Mattar Cunha, Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS
    Publication number: 20200101046
    Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 2, 2020
    Inventors: Laura BRANDOLINI, Marcello ALLEGRETTI, Mauro Martins TEIXEIRA
  • IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME UROLOGICAL DISORDERS
    Publication number: 20190336484
    Abstract: The present invention relates to IL-8 inhibitor compounds for use in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and benign prostatic hyperplasia.
    Type: Application
    Filed: January 2, 2018
    Publication date: November 7, 2019
    Inventors: Maria Candida CESTA, Marcello ALLEGRETTI, Andrea ARAMINI, Gianluca BIANCHINI, Laura BRANDOLINI
  • 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA
    Publication number: 20190106395
    Abstract: The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Andrea ARAMINI, Gianluca Bianchini, Laura Brandolini, Andrea Beccari, Samuele Lillini, Giuseppe Nano