Patents by Inventor Laura J. Van't Veer

Laura J. Van't Veer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180305768
    Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.
    Type: Application
    Filed: March 1, 2018
    Publication date: October 25, 2018
    Applicants: The Netherlands Cancer Institute, Merck Sharp & Dohme Corp.
    Inventors: HongYue Dai, Yudong He, Peter S. Linsley, Mao Mao, Christopher J. Roberts, Laura Johanna Van't Veer, Marc J. Van de Vijver, Rene Bernards, A.A. M. Hart
  • Publication number: 20140364434
    Abstract: Methods and systems for identifying a cancer patient suitable for treatment with a PARP inhibitor. A 6-gene, 7-gene and 8-gene predictor panels of genes that are predictive of patient resistance or sensitivity to PARP inhibitors such as Olaparib.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Anneleen Daeman, Denise M. Wolf, Laura J. Van 't Veer, Paul T. Spellman, Joe W. Gray
  • Patent number: 8105777
    Abstract: The present invention relates to genetic markers whose expression is correlated with colon cancer. In one aspect, the invention provides sets of markers whose expression can be used for classifying colon cancer patients into different prognostic categories. In another aspect, the invention provides kits containing marker sets for determining prognosis of colon cancer. In another aspect, the invention provides methods of classifying cancer patients with regard to prognosis.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: January 31, 2012
    Assignees: Nederlands Kanker Instituut, Merck Sharp & Dohme Corp.
    Inventors: Hongyue Dai, Laura J. Van't Veer, Yudong He
  • Patent number: 8019552
    Abstract: The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: September 13, 2011
    Assignees: The Netherlands Cancer Institute, Merck Sharp & Dohme Corp.
    Inventors: Hongyue Dai, Laura J. Van't Veer, John Lamb, Roland Stoughton, Stephen H. Friend, Yudong He
  • Publication number: 20090239214
    Abstract: The present invention relates to sets of genetic markers whose expression is correlated with prognosis of breast cancer in individuals having breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate individuals having a good prognosis, e.g., no reoccurrence or metastasis within five years of initial diagnosis, and individuals having a poor prognosis, e.g., reoccurrence or metastasis within five years of initial diagnosis. The invention relates to methods of prognosis using these markers. The invention also relates to microarrays containing probes to these markers, and to kits containing ready-to-use microarrays and computer software for data analysis using the prognostic and statistical methods disclosed herein.
    Type: Application
    Filed: August 1, 2005
    Publication date: September 24, 2009
    Inventors: Hongyue Dai, Yudong He, Mao Mao, Bernard Fine, Laura J. van't Veer, Marc J. van de Vijver
  • Publication number: 20080187909
    Abstract: The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 7, 2008
    Applicants: NETHERLANDS CANCER INSTITUTE, THE, ROSETTA INPHARMATICS LLC
    Inventors: Hongyue Dai, Laura J. Van't Veer, John Lamb, Roland Stoughton, Stephen H. Friend, Yudong He