Patents by Inventor Lauren O. Bakaletz

Lauren O. Bakaletz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200155620
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Application
    Filed: June 21, 2019
    Publication date: May 21, 2020
    Applicants: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
  • Patent number: 10624934
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: April 21, 2020
    Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
  • Patent number: 10595530
    Abstract: Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: March 24, 2020
    Assignees: Nationwide Children's Hospital, Inc., University of Southern California
    Inventors: Steven D. Goodman, Lauren O. Bakaletz
  • Publication number: 20200002409
    Abstract: This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
    Type: Application
    Filed: August 16, 2018
    Publication date: January 2, 2020
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Steven D. Goodman, Lauren O. Bakaletz
  • Publication number: 20190337996
    Abstract: The disclosure provides methods and compositions that are useful to lessen and/or cure bacterial biofilms and treat diseases or disorders associated with biofilms using one or more novel polypeptide vaccines, antibodies, antibody fragments and compositions. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
    Type: Application
    Filed: January 3, 2018
    Publication date: November 7, 2019
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Lauren O. Bakaletz, Steven D. Goodman
  • Publication number: 20190338018
    Abstract: This disclosure provides antibody fragments and isolated polypeptides comprising the antibody fragments that are useful as a therapeutic for those with an existing infection characterized by the formation of biofilms. Antibody fragments and isolated polypeptides comprising the antibody fragments can be administered to detect, treat, or prevent infection and/or remediate biofilms. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
    Type: Application
    Filed: January 3, 2018
    Publication date: November 7, 2019
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Lauren O. Bakaletz, Steven D. Goodman
  • Publication number: 20190324037
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Application
    Filed: June 24, 2019
    Publication date: October 24, 2019
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Patent number: 10369176
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: August 6, 2019
    Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
  • Patent number: 10345300
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: July 9, 2019
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITY
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Publication number: 20190000971
    Abstract: This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system.
    Type: Application
    Filed: August 1, 2016
    Publication date: January 3, 2019
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Lauren O. Bakaletz, Steven D. Goodman
  • Publication number: 20190004046
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Application
    Filed: July 18, 2018
    Publication date: January 3, 2019
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Publication number: 20180303900
    Abstract: Methods of and compositions for breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of an interfering agent capable of specifically competing, titrating, or inhibiting the binding of an HU protein to a microbial DNA. By competing with HU proteins that bind to DNA scaffold in the biofilm, these interfering agents destabilize the biofilm leading to destruction and removal of the biofilm by the immune system. Further method and composition aspects are contemplated in relation to infections caused by bacteria that export an HU protein.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 25, 2018
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Lauren O. Bakaletz, Steven D. Goodman
  • Patent number: 10048261
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 14, 2018
    Assignees: THE OHIO STATE UNIVERSITY, NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Patent number: 9987343
    Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 5, 2018
    Assignee: NATIONWIDE CHILDREN'S HOSPITAL, INC.
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr.
  • Publication number: 20180071381
    Abstract: Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a subject including applying, to at least a portion of the subject's post-auricular region, a topical delivery system including a therapeutically effective amount of a topical pharmaceutical composition comprising at least one active agent and a pharmaceutically acceptable carrier and/or adjuvant. The topical pharmaceutical composition can include a topical immunogenic composition. The topical delivery system can further include a flexible substrate in communication with the topical immunogenic composition. The subject can be a pediatric subject.
    Type: Application
    Filed: November 28, 2017
    Publication date: March 15, 2018
    Inventor: Lauren O. Bakaletz
  • Publication number: 20180000878
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Application
    Filed: July 13, 2017
    Publication date: January 4, 2018
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
  • Patent number: 9855326
    Abstract: Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a subject, including applying, to at least a portion of the subject's post-auricular region, a topical delivery system including a therapeutically effective amount of a topical pharmaceutical composition comprising at least one active agent and a pharmaceutically acceptable carrier and/or adjuvant. The topical pharmaceutical composition can include a topical immunogenic composition. The topical delivery system can further include a flexible substrate in communication with the topical immunogenic composition. The subject can be a pediatric subject.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: January 2, 2018
    Assignee: Research Institute at Nationwide Children's Hospital
    Inventor: Lauren O. Bakaletz
  • Publication number: 20170209504
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Application
    Filed: September 6, 2016
    Publication date: July 27, 2017
    Applicants: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
  • Publication number: 20170184589
    Abstract: The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
    Type: Application
    Filed: January 12, 2017
    Publication date: June 29, 2017
    Inventors: Subinoy Das, Lauren O. Bakaletz
  • Publication number: 20170106075
    Abstract: The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
    Type: Application
    Filed: December 21, 2016
    Publication date: April 20, 2017
    Inventors: Lauren O. Bakaletz, Robert S. Munson, JR.