Patents by Inventor Laurence A. Roth

Laurence A. Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200338233
    Abstract: Provided are methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions or polymer-containing formulations that can form a hydrogel in the eye of a subject. In certain embodiments, the hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
    Type: Application
    Filed: January 11, 2019
    Publication date: October 29, 2020
    Applicant: Pykus Therapeutics, Inc.
    Inventors: Laurence A. ROTH, James Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI, John Solomon GARNER
  • Publication number: 20190216982
    Abstract: The invention provides methods and polymer-containing formulations for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups. Formulations are provided containing a nucleo-functional polymer, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier, for use in the therapeutic methods.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 18, 2019
    Inventors: Laurence A. ROTH, James Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI, John Solomon GARNER
  • Patent number: 9795762
    Abstract: Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a length of 10 cm measured from the distal end of the catheter body, and at least two lumen, each of the catheter body lumen having a proximal end, a distal end, a Lumen Aspect Ratio of at least 3:1, and an intraluminal surface, the distal ends of the at least two catheter body lumen being (i) non-coterminus or (ii) laser-cut, the exterior surface of the catheter body in the tip region or the intraluminal surface of the two catheter body lumen comprising a hydrophilic polymer layer having an Average Dry Thickness of at least about 50 nanometers.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 24, 2017
    Assignee: ARROW INTERNATIONAL, INC.
    Inventors: Michael Bouchard, Zheng Zhang, Jun Li, Matt Skinner, Laurence Roth, Douglas Weaver, Eric W. Marchese, Robert Reed, Chad Huval, Christopher R. Loose
  • Patent number: 9764069
    Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: September 19, 2017
    Assignee: Semprus BioSciences Corporation
    Inventors: Laurence A. Roth, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose
  • Publication number: 20140037967
    Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
    Type: Application
    Filed: October 2, 2013
    Publication date: February 6, 2014
    Applicant: Semprus Biosciences Corporation
    Inventors: Laurence A. ROTH, Zheng ZHANG, Chad C. HUVAL, Michael A. BOUCHARD, Christopher R. LOOSE
  • Patent number: 8632838
    Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: January 21, 2014
    Assignee: Semprus Biosciences Corporation
    Inventors: Laurence A. Roth, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose
  • Publication number: 20120084309
    Abstract: Methods and systems are disclosed that identify date elements for a client, determine whether the identified date elements are excluded based on client profile information, determine whether the identified date elements are excluded based on respective profile information of two or more of the members of the client, and provide to the client one or more of the identified date elements that are consistent with the client profile information or the profile information of the two or more of the members.
    Type: Application
    Filed: October 4, 2011
    Publication date: April 5, 2012
    Applicant: TDNC Corp.
    Inventors: Robert SCHUMANN, Laurence ROTH, Richard WHITTEMORE, Mary SCHUMANN
  • Publication number: 20110305895
    Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
    Type: Application
    Filed: June 9, 2011
    Publication date: December 15, 2011
    Inventors: Laurence A. Roth, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose
  • Publication number: 20070005127
    Abstract: A device for treating a heart may comprise a myocardial section configured to be positioned in a heart wall between a coronary vessel and a chamber of the heart and a vessel section configured to be positioned in the coronary vessel. The vessel section may be connected to the myocardial section and be configured to articulate relative to the myocardial section. The myocardial section and the vessel section may form an integral, single piece structure.
    Type: Application
    Filed: June 17, 2005
    Publication date: January 4, 2007
    Inventors: Peter Boekstegers, Patrick Cahalan, Laurence Roth, Jianlu Ma, Earl Bardsley, Justin Callaway, James Duronio, Steve Opolski, Wendy Graczyk
  • Patent number: 6911216
    Abstract: Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.
    Type: Grant
    Filed: November 18, 1998
    Date of Patent: June 28, 2005
    Assignee: Genzyme Corporation
    Inventors: Laurence A. Roth, Stephen Jack Herman
  • Publication number: 20050070993
    Abstract: Methods, and related devices, for treating a heart by allowing retrograde blood flow in a coronary vein may include flowing blood through a passageway between a blood-containing anatomical structure and a coronary vein so as to cause retrograde blood flow in the coronary vein. The methods, and related devices, may further include measuring an internal pressure of the coronary vein to determine a measured internal pressure and at least partially obstructing the coronary vein at a location upstream of the passageway relative to a direction of the retrograde blood flow based on the measured internal pressure.
    Type: Application
    Filed: September 29, 2003
    Publication date: March 31, 2005
    Inventors: Peter Boekstegers, Peter Wilk, Laurence Roth, Jianlu Ma, Earl Bardsley
  • Publication number: 20040147868
    Abstract: A device for treating a heart includes an implant and a collar. The implant may be configured to be positioned in a heart wall between a coronary vessel and a chamber of the heart. The collar may be configured to be disposed externally on a portion of the implant such that the collar extends from the implant so as to contact the heart wall for anchoring the implant in position in the heart wall.
    Type: Application
    Filed: January 27, 2003
    Publication date: July 29, 2004
    Inventors: Earl Bardsley, Peter Boekstegers, Patrick Cahalan, Michael Igoe, Jianlu Ma, Anna McVittie, Laurence Roth
  • Publication number: 20040091462
    Abstract: Various embodiments of the present invention relate to compositions for delivering bone growth inducing material (e.g., to viable bone and/or other skeletal tissues to repair defects and the like). More particularly, various embodiments of the present invention relate to delivery mechanisms for an osteotherapeutic material (e.g., osteoinductive and/or osteoconductive materials), including (but not limited to) demineralized bone matrix (“DBM”) and cortical-cancellous bone chips (“CCC”). Certain compositions according to various embodiments of the present invention may comprise mixtures of a physiologically acceptable biodegradable carrier, an osteoinductive material, and/or an osteoconductive material (e.g., DBM and CCC). The compositions may thus be applied (for example, to defective bone tissue and/or other viable tissue) to induce formation of new bone. Other embodiments of the present invention relate to the preparation of compositions and methods of using such compositions.
    Type: Application
    Filed: August 20, 2003
    Publication date: May 13, 2004
    Inventors: Steve T. Lin, Luis Z. Avila, Arthur J. Coury, Hidegard M. Kramer, Laurence A. Roth, Rebecca Roberts, Michael Kurt Sly
  • Publication number: 20030216678
    Abstract: A method for inducing vascular remodeling and related methods for treating patients having diseased vasculature. The method of inducing remodeling of the vascular system includes altering the blood flow dynamics in portions of the vascular system via mechanical mechanisms. Remodeling of certain coronary vasculature may be induced by creating a passage in a heart wall between a heart chamber and a blood vessel so as to permit blood flow communication, for example, direct blood flow communication, between the chamber and the vessel. A method of inducing vascular remodeling may include providing a blood flow passage between a heart chamber and the coronary vessel, or other flow dynamics altering structure, such that enlargement of at least a portion of the coronary vessel occurs.
    Type: Application
    Filed: March 17, 2003
    Publication date: November 20, 2003
    Inventors: Keith March, Richard Popp, Peter Fitzgerald, Patrick Cahalan, Daniel Burkhoff, Laurence Roth, Nancy Briefs, William Santamore, Robert Swain, Peter Boekstegers, Vincent Pompili
  • Publication number: 20020032478
    Abstract: The method and apparatus described and illustrated herein generally relate to a bypass method to provide blood flow directly from a heart chamber, such as the left ventricle, and coronary vasculature, such as a coronary artery, and a conduit especially suited for placement in the myocardium to provide such flow. The conduit is particularly useful when a blockage partially or completely obstructs the coronary artery, in which case the conduit is positioned distal to the blockage. Aspects of the present invention relate to conduits in the form of stents that have particular configurations exhibiting properties suited to placement in the myocardium.
    Type: Application
    Filed: July 31, 2001
    Publication date: March 14, 2002
    Applicant: Percardia, Inc.
    Inventors: Peter Boekstegers, Nancy Briefs, Jerrick Buck, Laurence A. Roth, Robert Swain
  • Patent number: 6176871
    Abstract: A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: January 23, 2001
    Assignee: Focal, Inc.
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Jeffrey A. Hubbell, Stephen J. Herman, Laurence A. Roth, Patrick K. Campbell, Kevin M. Berrigan, Peter K. Jarrett, Arthur J. Coury
  • Patent number: 5879713
    Abstract: Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: March 9, 1999
    Assignee: Focal, Inc.
    Inventors: Laurence A. Roth, Stephen Jack Herman
  • Patent number: 5849035
    Abstract: A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
    Type: Grant
    Filed: October 30, 1995
    Date of Patent: December 15, 1998
    Assignee: Focal, Inc.
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Jeffrey A. Hubbell, Stephen J. Herman, Laurence A. Roth, Patrick K. Campbell, Kevin M. Berrigan, Peter K. Jarrett, Arthur J. Coury
  • Patent number: 5779673
    Abstract: Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.
    Type: Grant
    Filed: June 26, 1995
    Date of Patent: July 14, 1998
    Assignee: Focal, Inc.
    Inventors: Laurence A. Roth, Stephen J. Herman, Farhad Khosravi, David Melanson, Michael Dumont, Patrick K. Campbell, John C. Spiridigliozzi
  • Patent number: 5741323
    Abstract: A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 21, 1998
    Assignee: Focal, Inc.
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Jeffrey A. Hubbell, Stephen J. Herman, Laurence A. Roth, Patrick K. Campbell, Kevin M. Berrigan, Peter K. Jarrett, Arthur J. Coury