Patents by Inventor Laurence Gauzy
Laurence Gauzy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9056914Abstract: Provided herein are compounds of formula (I):Type: GrantFiled: January 25, 2013Date of Patent: June 16, 2015Assignee: SANOFIInventors: Alain Commercon, Laurence Gauzy-Lazo, Philippe Hubert
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Publication number: 20140155590Abstract: The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation of the conjugates, to their application as anticancer agents and to the dimers themselves.Type: ApplicationFiled: June 21, 2013Publication date: June 5, 2014Inventors: Alain Commercon, Laurence Gauzy-Lazo
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Patent number: 8481042Abstract: The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation of the conjugates, to their application as anticancer agents and to the dimers themselves.Type: GrantFiled: February 24, 2012Date of Patent: July 9, 2013Assignee: SanofiInventors: Alain Commercon, Laurence Gauzy-Lazo
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Patent number: 8404678Abstract: The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.Type: GrantFiled: January 19, 2010Date of Patent: March 26, 2013Assignee: SanofiInventors: Hervé Bouchard, Ravi V. J. Chari, Alain Commerçon, Yonghong Deng, Laurence Gauzy
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Patent number: 8288425Abstract: The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.Type: GrantFiled: January 4, 2005Date of Patent: October 16, 2012Assignee: Aventis Pharmaceuticals Inc.Inventors: Michael L. Edwards, Paul J. Cox, Shelley Amendola, Stephanie D. Deprets, Timothy A. Gillespy, Christopher D. Edlin, Andrew D. Morley, Charles J. Gardner, Brian Pedgrift, Herve Bouchard, Didier Babin, Laurence Gauzy, Alain Le-Brun, Tahir N. Majid, John C. Reader, Lloyd J. Payne, Nawaz M. Khan, Michael Cherry
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Publication number: 20120244172Abstract: The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation of the conjugates, to their application as anticancer agents and to the dimers themselves.Type: ApplicationFiled: February 24, 2012Publication date: September 27, 2012Applicant: SANOFIInventors: Alain Commercon, Laurence Gauzy-Lazo
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Patent number: 8163736Abstract: The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.Type: GrantFiled: July 16, 2008Date of Patent: April 24, 2012Assignee: sanofi-aventisInventors: Laurence Gauzy, Herve Bouchard, Ravi V. J. Chari, Alain Commercon, Robert Zhao, Yonghong Deng, Wei Li
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Publication number: 20100316656Abstract: The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.Type: ApplicationFiled: January 19, 2010Publication date: December 16, 2010Applicant: sanofi-aventisInventors: Hervé Bouchard, Ravi V.J. Chari, Alain Commercon, Yonghong Deng, Laurence Gauzy
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Patent number: 7517902Abstract: Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.Type: GrantFiled: December 4, 2006Date of Patent: April 14, 2009Assignee: Aventis Pharma S.A.Inventors: Frank Halley, Michel Tabart, Hervé Bouchard, Catherine Souaille, Alain Le Brun, Fabrice Viviani, Laurence Gauzy-Lazo, Pascal Desmazeau, Odile Angouillant-Boniface, Bruno Filoche-Romme
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Publication number: 20090036431Abstract: The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.Type: ApplicationFiled: July 16, 2008Publication date: February 5, 2009Applicant: SANOFI-AVENTISInventors: Laurence GAUZY, Herve BOUCHARD, Ravi V.J. CHARI, Alain COMMERCON, Robert ZHAO, Yonghong DENG, Wei LI
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Patent number: 7435820Abstract: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.Type: GrantFiled: May 23, 2006Date of Patent: October 14, 2008Assignee: Aventis Pharma S.A.Inventors: Fabienne Thompson, Catherine Souaille, Fabrice Viviani, Michel Tabart, Patrick Mailliet, Teresa Damiano, Marie-Pierre Cherrier, Francois Clerc, Frank Halley, Herve Bouchard, Laurence Gauzy-Lazo, Bernard Baudoin
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Publication number: 20080125418Abstract: The invention discloses and claims benzimidazole compounds of formula (I): wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl or a saturated 5- or 6-membered monocyclic heterocyclic radical or a bicyclic heterocyclic radical; and A5 is H or alkyl; or a stereoisomer, a racemate, an enantiomer or a diastereoisomer of said compound of formula (I) or a pharmaceutically acceptable salt thereof; the use of compounds of formula (I) for the treatment of a disorder of proliferation of blood vessels, uncontrolled angiogenesis, a fibrotic disorder, a disorder of proliferation of mesangial cells, a metabolic disorder, allergy, asthma, thrombosis, a disease of the nervous system, retinopathy, psoriasis, rheumatoid arthritis, diabetes, muscle degeneration, solid tumors and cancers, pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents and pharmaceutical compositions comprising a compouType: ApplicationFiled: November 20, 2007Publication date: May 29, 2008Applicant: AVENTIS PHARMA S.A.Inventors: Didier Babin, Alain Le Brun, Laurence Gauzy-Lazo, Herve Bouchard
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Publication number: 20070161626Abstract: Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.Type: ApplicationFiled: December 4, 2006Publication date: July 12, 2007Applicant: Aventis Pharma S.A.Inventors: Frank Halley, Michel Tabart, Herve Bouchard, Catherine Souaille, Alain Le Brun, Fabrice Viviani, Laurence Gauzy-Lazo, Pascal Desmazeau, Odile Angouillant-Boniface, Bruno Filoche-Romme
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Patent number: 7109340Abstract: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.Type: GrantFiled: July 9, 2004Date of Patent: September 19, 2006Assignee: Aventis Pharma S.A.Inventors: Fabienne Thompson, Patrick Mailliet, Teresa Damiano, Marie-Pierre Cherrier, Francois Clerc, Frank Halley, Hervé Bouchard, Laurence Gauzy-Lazo, Bernard Baudoin, Catherine Souaille, Fabrice Viviani, Michel Tabart
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Publication number: 20060199837Abstract: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.Type: ApplicationFiled: May 23, 2006Publication date: September 7, 2006Applicant: AVENTIS PHARMA S.A.Inventors: Fabienne Thompson, Patrick Mailliet, Teresa Damiano, Marie-Pierre Cherrier, Francois Clerc, Frank Halley, Herve Bouchard, Laurence Gauzy-Lazo, Bernard Baudoin, Catherine Squaille, Fabrice Viviani, Michel Tabart
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Publication number: 20060014756Abstract: The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.Type: ApplicationFiled: January 4, 2005Publication date: January 19, 2006Applicant: AVENTIS PHARMACEUTICALS INC.Inventors: Michael Edwards, Paul Cox, Shelley Amendola, Stephanie Deprets, Timothy Gillespy, Christopher Edlin, Andrew Morley, Charles Gardner, Brian Pedgrift, Herve Bouchard, Didier Babin, Laurence Gauzy, Alain Le-Brun, Tahir Majid, John Reader, Lloyd Payne, Nawaz Khan, Michael Cherry
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Patent number: 6897208Abstract: The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.Type: GrantFiled: October 24, 2002Date of Patent: May 24, 2005Assignee: Aventis Pharmaceuticals Inc.Inventors: Michael L. Edwards, Paul J. Cox, Shelley Amendola, Stephanie D. Deprets, Timothy A. Gillespy, Christopher D. Edlin, Andrew D. Morley, Charles J. Gardner, Brian Pedgrift, Herve Bouchard, Didier Babin, Laurence Gauzy, Alain Le-Brun, Tahir N. Majid, John C. Reader, Lloyd J. Payne, Nawaz M. Khan, Michael Cherry
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Publication number: 20050096345Abstract: Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.Type: ApplicationFiled: July 9, 2004Publication date: May 5, 2005Applicant: Aventis Pharma S.A.Inventors: Fabienne Thompson, Patrick Mailliet, Teresa Damiano, Marie-Pierre Cherrier, Francois Clerc, Frank Halley, Herve Bouchard, Laurence Gauzy-Lazo, Bernard Baudoin, Catherine Souaille, Fabrice Viviani, Michel Tabart
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Publication number: 20050009894Abstract: The invention discloses and claims benzimidazole compounds of formula (I): wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl or a saturated 5- or 6-membered monocyclic heterocyclic radical or a bicyclic heterocyclic radical; and A5 is H or alkyl; or a stereoisomer, a racemate, an enantiomer or a diastereoisomer of said compound of formula (I) or a pharmaceutically acceptable salt thereof; the use of compounds of formula (I) for the treatment of a disorder of proliferation of blood vessels, uncontrolled angiogenesis, a fibrotic disorder, a disorder of proliferation of mesangial cells, a metabolic disorder, allergy, asthma, thrombosis, a disease of the nervous system, retinopathy, psoriasis, rheumatoid arthritis, diabetes, muscle degeneration, solid tumors and cancers, pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents and pharmaceutical compositions comprising a compouType: ApplicationFiled: April 20, 2004Publication date: January 13, 2005Applicant: Aventis Pharma S.A.Inventors: Didier Babin, Alain Le Brun, Laurence Gauzy-Lazo, Herve Bouchard
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Publication number: 20040048868Abstract: The invention is directed to physiologically active compounds of the general formula (Ix) 1Type: ApplicationFiled: October 24, 2002Publication date: March 11, 2004Inventors: Michael L. Edwards, Paul J. Cox, Shelley Amendola, Stephanie D. Deprets, Timothy A. Gillespy, Christopher D. Edlin, Andrew D. Morley, Charles J. Gardner, Brian Pedgrift, Herve Bouchard, Didier Babin, Laurence Gauzy, Alain Le-Brun, Tahir N. Majid, John C. Reader, Lloyd J. Payne, Nawaz M. Khan, Michael Cherry