Abstract: Devices and methods utilizing a catheter to remodel soft tissue of a patient and, in a preferred embodiment, to reduce the volume of the left ventricle of a heart. In some embodiments, one or more sutures are passed through a wall of the ventricle. The ends of the one suture and, more preferably, the multiples sutures are drawn together to draw tissue portions towards one another. In some embodiments, a tissue remodeling clip is implanted into a wall of the ventricle. Ends of the clip are resiliently biased to move relative to one another to draw tissue portions towards one another. In some embodiments, a tissue remodeling anchor includes a base and a plurality of legs attached to the base. The legs of the tissue anchor are implanted into a wall of the ventricle and moved toward one another to draw tissue portions toward one another.

Abstract: A bone tamp for creating channels within bone tissue. The bone tamp includes an elongated member that is deformable from a first generally non-linear configuration to a second generally linear configuration for insertion into bone tissue. As the elongated member is deployed into bone tissue, it transitions from the linear configuration into the non-linear configuration within the bone tissue. The elongated member is capable of being deformed back into the generally linear configuration for withdrawal from the bone tissue.

Abstract: A surgical fastener comprising a clip movable between an open configuration and a closed configuration and a biasing member contacting the clip and biasing the dip to its open configuration when the biasing member is actuated. The biasing member and clip both tend to assume the closed configuration when no external forces are applied to them. A needle may be releasably attached to the clip. Methods for making the fasteners are also disclosed, in which both the clip and the biasing member are set in the closed position.

Abstract: Tissue connector assemblies having at least two piercing members, each releaseably coupled to a surgical fastener such as a surgical clip. A flexible member such as a suture may be used to couple one or both piercing members to respective ends of the fastener.

Abstract: A sealing clip for sealing or holding punctures or openings in tissue closed is applied from the inner surface of the tissue. A delivery apparatus is used to releasably hold the clip in one configuration for introduction of the clip through the puncture or opening and expand the clip to a more open configuration for pulling the clip through the tissue as the delivery apparatus is retracted. Further retraction of the delivery apparatus causes the edges of the tissue surrounding the opening to move along the clip and come together after which the clip is released and closed to hold the tissue edges of the opening together. In the case where the clip has a memory set closed shape, the clip returns toward that shape after being released to hold the tissue edges of the opening together, thereby holding the opening closed.

Abstract: Apparatus and methods for performing an anastomosis. More particularly, the apparatus may be used to perform a single or multiple anastomosis with the ability of maintaining fluid flow (e.g., blood) through the anastomosis vessel according to one aspect of the invention.

Abstract: The present disclosure relates to devices and methods for creating channels within bone. One method for treating bone generally includes traversing an elongated member through cancellous bone of a vertebral body along a first generally non-linear path and then retracting the elongated member, thereby leaving a generally non-linear channel. The elongated member then is traversed through the cancellous bone along a second generally non-linear path, which second path does not completely coincide with the first path and then retracted along the second generally nonlinear path, thereby leaving a second generally non-linear channel. Optionally, bone filler material is deployed into the channels.

Abstract: Methods and systems for closing an opening or defect in tissue, closing a lumen or tubular structure, cinching or remodeling a cavity or repairing a valve preferably utilizing a purse string or elastic device. The preferred devices and methods are directed toward catheter-based percutaneous, transvascular techniques used to facilitate placement of the devices within lumens, such as blood vessels, or on or within the heart to perform structural defect repair, such as valvular or ventricular remodeling. In some methods, the catheter is positioned within the right ventricle, wherein the myocardial wall or left ventricle may be accessed through the septal wall to position a device configured to permit reshaping of the ventricle. The device may include a line or a plurality of anchors interconnected by a line. In one arrangement, the line is a coiled member.

Abstract: A system for anastomosing a first tubular structure to a second tubular structure having an opening formed therein comprises a support device having a plurality of arms forming spaces therebetween and a plurality of piercing members slidably coupled to the arms. The support device piercing members have a retracted state and an extended state to support the first tubular structure thereon for placement within an opening in the second tubular structure to facilitate anastomosing the tubular structures together. The arms can be configured to urge the first tubular structure against the portion of the second tubular structure surrounding the opening to form a seal therebetween. According to one embodiment, a plurality of discrete fasteners are provided to pass through the support device spaces and the first and second tubular structures. In another embodiment, fasteners are integrated into the support device and releasably coupled thereto for delivery to the anastomosis site.

Abstract: A sealing clip for sealing or holding punctures or openings in tissue closed is applied from the inner surface of the tissue. In one embodiment, the clip has piercing members for penetrating the tissue from an inner surface thereof adjacent the opening. A delivery apparatus is used to releasably hold the clip in one configuration for introduction of the clip through the puncture or opening and expand the clip to a more open configuration for pulling the clip through the tissue as the delivery apparatus is retracted. Further retraction of the delivery apparatus causes the edges of the tissue surrounding the opening to move along the clip and come together after which the clip is released and closed to hold the tissue edges of the opening together. In the case where the clip has a memory set closed shape, the clip returns toward that shape after being released to hold the tissue edges of the opening together, thereby holding the opening closed.

Abstract: Apparatus and methods for performing an anastomosis. More particularly, the apparatus may be used to perform a single or multiple anastomosis with the ability of maintaining fluid flow (e.g., blood) through the anastomosis vessel according to one aspect of the invention.

Abstract: A novel bridge clip tissue connector includes two clips separated by a bridge portion. The clips allow for the connecting of tissue at two positions that are maintained by the bridge portion. The connector can be used for performing a wide variety of surgical procedures, including anastomosis and a horizontal mattress suture-like connection.

Abstract: An annuloplasty system for repairing a valve in a patient's heart comprises a surgical implant including a member having first and second end portions. The implant member further is configured and/or adapted to form a partial ring along a portion of one of the valve annulae of a patient's heart such as the mitral or tricuspid valve annulus. The implant member is axially elastic such that it can axially expand and contract and includes first and second anchors extending from the end portions of the implant member. The anchors are adapted to anchor the implant in tissue such as the mitral or tricuspid valve annulus. The system can facilitate tissue plication (e.g., of the posterior annulus of the mitral valve or the annulus of the tricuspid valve) and reinforcement of a valve annulus.

Abstract: The present invention relates to methods of separating, supporting or both separating and supporting layers of tissue in the human spine. Such methods generally comprise inserting at least one member between layers of tissue in the human spine and changing the configuration of the member to define a support structure between the tissue layers.

Abstract: A novel bridge clip tissue connector includes two clips separated by a bridge portion. The clips allow for the connecting of tissue at two positions that are maintained by the bridge portion. The connector can be used for performing a wide variety of surgical procedures, including anastomosis and a horizontal mattress suture-like connection.

Abstract: A system for anastomosing a first tubular structure to a second tubular structure having an opening formed therein comprises a support device having a plurality of arms forming spaces therebetween and a plurality of piercing members slidably coupled to the arms. The support device piercing members have a retracted state and an extended state to support the first tubular structure thereon for placement within an opening in the second tubular structure to facilitate anastomosing the tubular structures together. The arms can be configured to urge the first tubular structure against the portion of the second tubular structure surrounding the opening to form a seal therebetween. According to one embodiment, a plurality of discrete fasteners are provided to pass through the support device spaces and the first and second tubular structures. In another embodiment, fasteners are integrated into the support device and releasably coupled thereto for delivery to the anastomosis site.

Abstract: Spinal tissue distraction devices that include at least one guide member for guiding a distraction device to a location between layers of spinal tissue. The guide member has a proximal end portion and a distal end portion. The distal end portion is adapted for insertion between the tissue layers and defines a shape of a desired support structure. The distraction device is slidably mounted on the guide member for advancing the distraction device distally along the guide member for insertion of the distraction device between the tissue layers. The distraction device substantially conforms to the shape defined by the distal end portion of the guide member to form a support structure that separates, supports or both separates and supports the tissue layers.

Abstract: Methods of separating and/or supporting layers of tissue in the human spine. Such methods generally comprise inserting at least a distal end portion of a guide member between layers of tissue in the human spine wherein the distal end portion defines a predetermined shape. A distraction device is advanced over at least the distal end portion of the guide member so that the distraction device substantially assumes the predetermined shape of the distal end portion of the guide member to form a support structure between the tissue layers that separates and/or supports the tissue layers.

Abstract: The present invention relates to methods of separating, supporting or both separating and supporting layers of tissue in the human spine. Such methods generally comprise inserting at least one member between layers of tissue in the human spine and changing the configuration of the member to define a support structure between the tissue layers.

Abstract: An apparatus for minimally invasive valve repair includes first and second needles, first and second flexible members, a clip, and first and second release mechanisms. The needles are each releasably connected to one of the opposing end points of the clip through a corresponding one of the flexible members via a corresponding one of the release mechanisms.