Patents by Inventor Laurie Lawin

Laurie Lawin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210002493
    Abstract: Disclosed herein are zwitterionic monomers, non-zwitterionic monomers, polyzwitterionic polymers formed therefrom; surface functionalization; surface modification; and articles containing any such compositions or surfaces formed therefrom.
    Type: Application
    Filed: May 17, 2018
    Publication date: January 7, 2021
    Inventors: Laurie Lawin, Anthony Gerten, Logan Sanow
  • Patent number: 10266620
    Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: April 23, 2019
    Assignee: Innovative Surface Technologies, Inc.
    Inventors: Jie Wen, Kristin Taton, Laurie Lawin, William Knopke, Eric Guire, Patrick Guire
  • Patent number: 10098989
    Abstract: The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: October 16, 2018
    Assignee: INNOVATIVE SURFACE TECHNOLOGIES, INC.
    Inventors: Kristin Taton, Laurie Lawin, Patrick Guire
  • Patent number: 10072241
    Abstract: Inventive concepts relate generally to the field of cell culture, and more particularly to formation of three-dimensional aggregate(s) of eukaryotic cells. Cell culture vessels including a conical device having an inner surface being hydrophobic; and a frustum defining an open viewing aperture and a narrow end of the conical device are described. Ceil culture vessel arrays, assemblies and kits are described, as well as methods of making and using the devices.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: September 11, 2018
    Assignee: INNOVATIVE SURFACE TECHNOLOGIES, INC.
    Inventors: Laurie Lawin, Briana Vogen, Daniel Guire, Tahmina Naqvi, Leandro Forciniti
  • Publication number: 20180043063
    Abstract: The present disclosure relates to a multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the coating, methods of using the coating, and articles that include the coating.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 15, 2018
    Inventors: Kristin Taton, Laurie Lawin, Patrick Guire
  • Publication number: 20170081435
    Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 23, 2017
    Inventors: Jie Wen, Kristin Taton, Laurie Lawin, William Knopke, Eric Guire, Patrick Guire
  • Patent number: 9539371
    Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: January 10, 2017
    Assignee: INNOVATIVE SURFACE TECHNOLOGIES, INC.
    Inventors: Jie Wen, Kristin Taton, Laurie Lawin, William Knopke, Eric Guire, Patrick Guire
  • Publication number: 20160032238
    Abstract: Inventive concepts relate generally to the field of cell culture, and more particularly to formation of three-dimensional aggregate(s) of eukaryotic cells. Cell culture vessels including a conical device having an inner surface being hydrophobic; and a frustum defining an open viewing aperture and a narrow end of the conical device are described. Ceil culture vessel arrays, assemblies and kits are described, as well as methods of making and using the devices.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Inventors: Laurie Lawin, Briana Vogen, Daniel Guire, Tahmina Naqvi, Leandro Forciniti
  • Publication number: 20150359944
    Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 17, 2015
    Inventors: Jie Wen, Kristin Taton, Laurie Lawin, William Knopke, Eric Guire, Patrick Guire
  • Publication number: 20120258313
    Abstract: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.
    Type: Application
    Filed: December 21, 2010
    Publication date: October 11, 2012
    Inventors: Jie Wen, Kristin Taton, Laurie Lawin, William Knopke, Eric Guire, Patrick Guire
  • Publication number: 20080031918
    Abstract: A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical device, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protection to the polymeric composition from mechanical damage and/or delamination during fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandable balloon, between which is positioned a barrier of the type described.
    Type: Application
    Filed: October 17, 2007
    Publication date: February 7, 2008
    Inventors: Laurie Lawin, Michelle Boucha-Rayle, Timothy Kloke
  • Publication number: 20070026037
    Abstract: The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.
    Type: Application
    Filed: July 26, 2006
    Publication date: February 1, 2007
    Inventors: Timothy Kloke, Robert Hergenrother, Laurie Lawin
  • Publication number: 20060110428
    Abstract: Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
    Type: Application
    Filed: July 5, 2005
    Publication date: May 25, 2006
    Inventors: Eugene deJuan, Signe Varner, Laurie Lawin
  • Publication number: 20060083772
    Abstract: A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.
    Type: Application
    Filed: October 6, 2005
    Publication date: April 20, 2006
    Inventors: David DeWitt, Michael Finley, Laurie Lawin
  • Publication number: 20060034891
    Abstract: The invention provides implantable medical devices that are fabricated, at least in part, from biodegradable polymeric material. The implantable medical devices are used to provide bioactive agent to a treatment site, and are particularly useful for treatment of limited access regions of the body.
    Type: Application
    Filed: July 5, 2005
    Publication date: February 16, 2006
    Inventors: Laurie Lawin, Aron Anderson
  • Publication number: 20060024350
    Abstract: The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.
    Type: Application
    Filed: June 24, 2005
    Publication date: February 2, 2006
    Inventors: Signe Varner, Patrick Guire, Kristin Taton, Jie Wen, Nathan Beeley, Laurie Lawin, Robert Hergenrother, Ralph Chappa, Aron Anderson
  • Publication number: 20060013835
    Abstract: The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
    Type: Application
    Filed: September 12, 2005
    Publication date: January 19, 2006
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050287188
    Abstract: The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 29, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050281863
    Abstract: The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 22, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050276837
    Abstract: The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 15, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa