Patents by Inventor Lawrence Greenfield

Lawrence Greenfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190171688
    Abstract: Interactive geographic information systems (GIS) and techniques are disclosed that provide users with a greater degree of flexibility, utility, and information. A markup language is provided that facilitates communication between servers and clients of the interactive GIS, which enables a number of GIS features, such as network links (time-based and/or view-dependent dynamic data layers), ground overlays, screen overlays, placemarks, 3D models, and stylized GIS elements, such as geometry, icons, description balloons, polygons, and labels in the viewer by which the user sees the target area. Also, “virtual tours” of user-defined paths in the context of distributed geospatial visualization is enabled. Streaming and interactive visualization of filled polygon data are also enabled thereby allowing buildings and other such features to be provided in 3D. Also, techniques for enabling ambiguous search requests in a GIS are provided.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Inventors: Lawrence Greenfield, Daniel Egnor, Francois Bailly, John Hanke
  • Patent number: 10198521
    Abstract: Interactive geographic information systems (GIS) and techniques are disclosed that provide users with a greater degree of flexibility, utility, and information. A markup language is provided that facilitates communication between servers and clients of the interactive GIS, which enables a number of GIS features, such as network links (time-based and/or view-dependent dynamic data layers), ground overlays, screen overlays, placemarks, 3D models, and stylized GIS elements, such as geometry, icons, description balloons, polygons, and labels in the viewer by which the user sees the target area. Also, “virtual tours” of user-defined paths in the context of distributed geospatial visualization is enabled. Streaming and interactive visualization of filled polygon data are also enabled thereby allowing buildings and other such features to be provided in 3D. Also, techniques for enabling ambiguous search requests in a GIS are provided.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: February 5, 2019
    Assignee: Google LLC
    Inventors: Lawrence Greenfield, Daniel Egnor, Francois Bailly, John Hanke
  • Patent number: 10001474
    Abstract: Fluorogenic semiconductor nanocrystals and compositions thereof are provided herein, including kits, assay systems and methods for their preparation and use.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: June 19, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Eric Welch, David Bussian, Michael Ignatius, Lawrence Greenfield
  • Publication number: 20170073359
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: September 26, 2016
    Publication date: March 16, 2017
    Inventors: Schuyler CORRY, William DOWNEY, Brian FILANOSKI, Kyle GEE, Lawrence GREENFIELD, James HIRSCH, Iain JOHNSON, Aleksey RUKAVISHNIKOV
  • Publication number: 20170016041
    Abstract: The disclosure provides stabilized reducing agents and methods for using them in sample preparation. Stabilized reducing agents described herein provide easy-to-use replacement reducing agents for reducing agents that undergo side-reactions that can render them ineffective as reducing agents and/or decrease the concentration of available reducing agent. In some cases, a stabilized reducing agent is an activatable reducing agent that can be activated upon application of a stimulus to the reducing agent.
    Type: Application
    Filed: May 17, 2016
    Publication date: January 19, 2017
    Inventors: Lawrence Greenfield, Christopher Hindson
  • Publication number: 20160314242
    Abstract: Compositions, processes and systems are provided for preparing and analyzing sample indexing of nucleic acid libraries for multiplexed sequencing analysis of diverse sample sets.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Inventors: MICHAEL SCHNALL-LEVIN, LAWRENCE GREENFIELD
  • Publication number: 20160139135
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: September 11, 2014
    Publication date: May 19, 2016
    Inventors: Schuyler CORRY, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Publication number: 20150284786
    Abstract: The invention provides methods and compositions to enhance the efficiency and sensitivity of molecular inversion probe (MIP) reactions. Probes include elements that allow MIP ends to abut for ligation while avoiding the possibility of polymerase strand displacement errors. Elements facilitate multiplexed detections, including MIP reaction product detections employing next generation sequencing (NGS) techniques.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 8, 2015
    Inventors: Michael H. Shapero, Lawrence Greenfield, Ronald J. Sapolsky, Keith Jones, Laurent Bellon, Robert J. Lipshutz, August Estabrook, John Efcavitch
  • Publication number: 20150169674
    Abstract: Interactive geographic information systems (GIS) and techniques are disclosed that provide users with a greater degree of flexibility, utility, and information. A markup language is provided that facilitates communication between servers and clients of the interactive GIS, which enables a number of GIS features, such as network links (time-based and/or view-dependent dynamic data layers), ground overlays, screen overlays, placemarks, 3D models, and stylized GIS elements, such as geometry, icons, description balloons, polygons, and labels in the viewer by which the user sees the target area. Also, “virtual tours” of user-defined paths in the context of distributed geospatial visualization is enabled. Streaming and interactive visualization of filled polygon data are also enabled thereby allowing buildings and other such features to be provided in 3D. Also, techniques for enabling ambiguous search requests in a GIS are provided.
    Type: Application
    Filed: June 27, 2006
    Publication date: June 18, 2015
    Inventors: Lawrence Greenfield, Daniel Egnor, Francois Bailly, John Hanke
  • Publication number: 20150132797
    Abstract: Compositions, methods and kits are disclosed for improved staining of a cell or tissue with a dye-conjugate that binds specifically to a particular component of the cell or tissue. The compositions, methods and kits include a polymeric material that reduces non-specific binding of a dye-conjugate to components of the cell or tissue other than the particular component specifically bound by the dye-conjugate. In some embodiments, the polymeric material is a synthetic polymer or a naturally-occurring polymer that is substituted by multiple sulfate, sulfonate, phosphate and/or phosphonate groups.
    Type: Application
    Filed: July 16, 2014
    Publication date: May 14, 2015
    Inventors: Brian FILANOSKI, Lawrence GREENFIELD, James HIRSCH
  • Publication number: 20150086988
    Abstract: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
    Type: Application
    Filed: October 2, 2014
    Publication date: March 26, 2015
    Inventors: Douglas BOST, Lawrence GREENFIELD
  • Patent number: 8865405
    Abstract: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: October 21, 2014
    Assignee: Applied BioSystems LLC
    Inventors: Douglas Bost, Lawrence Greenfield
  • Patent number: 8865891
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactamase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactamase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactamase or instructions for using the components in an assay.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: October 21, 2014
    Assignee: Life Technologies Corporation
    Inventors: Schuyler Corry, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Publication number: 20140193841
    Abstract: Fluorogenic semiconductor nanocrystals and compositions thereof are provided herein, including kits, assay systems and methods for their preparation and use.
    Type: Application
    Filed: June 7, 2012
    Publication date: July 10, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Eric Welch, David Bussian, Michael Ignatius, Lawrence Greenfield
  • Publication number: 20140065626
    Abstract: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
    Type: Application
    Filed: August 5, 2013
    Publication date: March 6, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Douglas A. BOST, Lawrence GREENFIELD
  • Patent number: 8507198
    Abstract: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: August 13, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Douglas A. Bost, Lawrence Greenfield
  • Publication number: 20130090470
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: September 13, 2012
    Publication date: April 11, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Schuyler CORRY, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Patent number: 8318450
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: November 27, 2012
    Assignee: Life Technologies Corporation
    Inventors: Schuyler Corry, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Publication number: 20120077211
    Abstract: Compositions, assays, methods, and kits are disclosed for use in applications that utilize oxidation of a chromogenic electron donor such as diaminobenzidine (DAB) to generate a signal. Applications include, but are not limited to, immunohistochemistry, chromogenic in situ hybridization, Western blots, Northern blots, Southern blots, ELISA assays, and microarray detection. The compositions, assays, methods, and kits disclosed herein make use of a novel, stabilized formulation of DAB and a novel, stabilized formulation of hydrogen peroxide.
    Type: Application
    Filed: December 15, 2009
    Publication date: March 29, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Lawrence Greenfield, Shawn Starkenburg, Matthew Shallice, Julie Nyhus, Louis Leong
  • Publication number: 20120040380
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: June 22, 2011
    Publication date: February 16, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: SCHUYLER BOON CORRY, WILLIAM LOUIS DOWNEY, BRIAN FILANOSKI, KYLE RICHARD GEE, I. LAWRENCE GREENFIELD, JAMES DAVID HIRSCH, IAIN JOHNSON, ALEKSEY RUKAVISHNIKOV