Patents by Inventor Leah Marie Johnson
Leah Marie Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11828685Abstract: Syntactic foams are materials including hollow microspheres distributed throughout a cured polymeric resin. Hollow microspheres within syntactic foams, including collapsible shells that enclose empty cavities, can serve as receptacles to capture environmental constituents upon applied temperature and pressure. An epoxy formulation including of EPON™ 828, HELOXY™ 61, and TETA was combined with hollow glass microspheres with isostatic crush strengths of 300, 3000, and 10,000 psi. Effects of pressure and temperature on the mechanical properties were evaluated via dynamic mechanical analysis. Storage modulus and glass transition temperature depended on formulation. Upon exposure to specific temperature and pressures, the hollow glass spheres embedded within the resin lose mechanical integrity and collapse, resulting in the generation of unencapsulated void spaces, primed to capture embedded liquid.Type: GrantFiled: February 25, 2021Date of Patent: November 28, 2023Assignee: Research Triangle InstituteInventors: Leah Marie Johnson, Nicolas Daniel Huffman
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Publication number: 20230165788Abstract: A reservoir device comprising an active agent formulation contained within a reservoir is described. The active agent formulation comprises more than one active agent. The reservoir is defined by a biodegradable, permeable polymer membrane. The membrane allows for diffusion of the more than one active agent of the formulation there through when positioned subcutaneously in a body of a subject.Type: ApplicationFiled: April 7, 2021Publication date: June 1, 2023Inventors: Leah Marie JOHNSON, Linying Alice LI, Sai Archana KROVI, Ariane VAN DER STRATEN
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Publication number: 20230094662Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g.Type: ApplicationFiled: November 7, 2022Publication date: March 30, 2023Inventors: Leah Marie Johnson, Ninell Pollas Mortensen, Ginger Denison Rothrock, Nicholas D. Huffman
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Publication number: 20230069918Abstract: The present disclosure relates to delivery and release compositions, systems, and methods of use thereof. In particular, the present disclosure relates to degradable polymeric systems including a first epoxy-containing monomer and a second, different epoxy-containing monomer, wherein the degradable polymeric system is crosslinked, and wherein one of the first epoxy-containing monomer and the second, different epoxy-containing monomer includes one or more ester groups; delivery systems incorporating degradable polymeric systems; and methods for providing cargo to a petroleum reservoir.Type: ApplicationFiled: January 26, 2021Publication date: March 9, 2023Inventors: Leah Marie Johnson, Nicolas Daniel Huffman, Jeffrey Brent Mecham, Ian Edward Stewart, Natalie Marie Girouard
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Patent number: 11518971Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g.Type: GrantFiled: November 26, 2019Date of Patent: December 6, 2022Assignee: RESEARCH TRIANGLE INSTITUTEInventors: Leah Marie Johnson, Ninell Pollas Mortensen, Ginger Denison Rothrock, Nicolas D. Huffman
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Publication number: 20210346661Abstract: A reservoir device comprising an active agent formulation contained within a reservoir is described. The reservoir is defined by a biodegradable, permeable polymer membrane having a thickness of at least 45 ?m. The membrane allows for diffusion of an active agent of the formulation there through when positioned subcutaneously in a body of a subject.Type: ApplicationFiled: October 16, 2019Publication date: November 11, 2021Inventors: Leah Marie JOHNSON, Ariane VAN DER STRATEN, Ginger Denison ROTHROCK, Linying Alice LI, Ellen LUECKE, Natalie GIROUARD, Zach Richard DEMKOVICH, Sai Archana KROVI
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Patent number: 11147763Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.Type: GrantFiled: October 25, 2016Date of Patent: October 19, 2021Assignee: RESEARCH TRIANGLE INSTITUTEInventors: Leah Marie Johnson, Stephanie Lynn Swarner, Ginger Denison Rothrock, Ariane Van Der Straten Ponthoz, Brian Rhys Stoner
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Publication number: 20210317360Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.Type: ApplicationFiled: June 23, 2021Publication date: October 14, 2021Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Publication number: 20210262904Abstract: Syntactic foams are materials including hollow microspheres distributed throughout a cured polymeric resin. Hollow microspheres within syntactic foams, including collapsible shells that enclose empty cavities, can serve as receptacles to capture environmental constituents upon applied temperature and pressure. An epoxy formulation including of EPON™ 828, HELOXY™ 61, and TETA was combined with hollow glass microspheres with isostatic crush strengths of 300, 3000, and 10,000 psi. Effects of pressure and temperature on the mechanical properties were evaluated via dynamic mechanical analysis. Storage modulus and glass transition temperature depended on formulation. Upon exposure to specific temperature and pressures, the hollow glass spheres embedded within the resin lose mechanical integrity and collapse, resulting in the generation of unencapsulated void spaces, primed to capture embedded liquid.Type: ApplicationFiled: February 25, 2021Publication date: August 26, 2021Inventors: Leah Marie Johnson, Nicolas Daniel Huffman
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Patent number: 11078411Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.Type: GrantFiled: January 17, 2017Date of Patent: August 3, 2021Assignee: Research Triangle InstituteInventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Sarah Dorothy Shepherd, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Patent number: 11078404Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.Type: GrantFiled: August 21, 2019Date of Patent: August 3, 2021Assignee: Research Triangle InstituteInventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Publication number: 20200165555Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g.Type: ApplicationFiled: November 26, 2019Publication date: May 28, 2020Inventors: Leah Marie Johnson, Ninell Pollas Mortensen, Ginger Denison Rothrock, Nicolas D. Huffman
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Publication number: 20190375982Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.Type: ApplicationFiled: August 21, 2019Publication date: December 12, 2019Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Patent number: 10421894Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.Type: GrantFiled: June 27, 2017Date of Patent: September 24, 2019Assignee: Research Triangle InstituteInventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Patent number: 10308864Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a carrier element forming an outer shell that defines an inner core. The core can include a reactive agent that is adapted to react with the shell, particularly at an inner interface of the shell with the core materials. The reaction can provide an inside-out degradation of the shell and release of one or more materials therein. The reactive agent may be separated from the shell, such as using a phase change material (PCM). Upon reaching specific environmental conditions, the PCM can change so as the release the reactive agent for reaction with the shell. The systems can be used in various methods to deliver a material to various environments, including underground reservoirs.Type: GrantFiled: May 9, 2018Date of Patent: June 4, 2019Assignee: RESEARCH TRIANGLE INSTITUTEInventors: Ginger D. Rothrock, Leah Marie Johnson
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Patent number: 10292909Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.Type: GrantFiled: March 12, 2018Date of Patent: May 21, 2019Assignees: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, RESEARCH TRIANGLE INSTITUTEInventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
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Publication number: 20190070104Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.Type: ApplicationFiled: October 25, 2016Publication date: March 7, 2019Inventors: Leah Marie Johnson, Stephanie Lynn Swarner, Ginger Denison Rothrock, Ariane Van Der Straten Ponthoz, Brian Rhys Stoner
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Publication number: 20190031951Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.Type: ApplicationFiled: January 17, 2017Publication date: January 31, 2019Inventors: Leah Marie Johnson, Ginger Denison Rothrock, Chasity Antoninette Norton, Sarah Dorothy Shepherd, Nicolas Daniel Huffman, Jeffrey Brent Mecham
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Publication number: 20180325781Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.Type: ApplicationFiled: March 12, 2018Publication date: November 15, 2018Applicants: Research Triangle Institute, The University of North Carolina at Chapel HillInventors: Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
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Publication number: 20180258340Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a carrier element forming an outer shell that defines an inner core. The core can include a reactive agent that is adapted to react with the shell, particularly at an inner interface of the shell with the core materials. The reaction can provide an inside-out degradation of the shell and release of one or more materials therein. The reactive agent may be separated from the shell, such as using a phase change material (PCM). Upon reaching specific environmental conditions, the PCM can change so as the release the reactive agent for reaction with the shell. The systems can be used in various methods to deliver a material to various environments, including underground reservoirs.Type: ApplicationFiled: May 9, 2018Publication date: September 13, 2018Inventors: Ginger D. Rothrock, Leah Marie Johnson