Abstract: A quaternary ammonium salt compound of formula I is fast-acting and has a long-term local anaesthetic effect after a single administration, the sensory nerve block time being longer than the motor nerve block time, has both a long-acting local anaesthetic effect and a selective local anaesthetic effect, and also significantly reduces the side effects of quaternary ammonium salt compounds with the structural features of surfactants and is highly safe; thus, the compound of formula I and the pharmaceutically acceptable salt thereof can be used for the preparation of saft drugs having a long-term local anaesthetic effect and a selective local anaesthetic effect

Abstract: Disclosed in the present invention are a cooling system, a stator assembly, and an axial magnetic field motor. The cooling system is used for cooling of a stator core, comprises a housing and an enclosed cavity for containing the stator core, and further comprises: a liquid spraying cavity provided on the housing and used for containing liquid; a liquid inlet in communication with the liquid spraying cavity; a liquid outlet in communication with the enclosed cavity; and a liquid spraying assembly provided on an inner wall, corresponding to the stator core, of the housing.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization and the ability to achieve specific hybridization without blocking DNA.

Abstract: This application discloses a method for controlling an optical sensing circuit, an optical sensing circuit, and an imaging device. The optical sensing circuit includes an optical sensor and a voltage dividing circuit connected in series, an input voltage (a voltage of the voltage dividing circuit) and an output voltage are obtained, a resistance value of the optical sensor is calculated according to the input voltage, a light intensity value is obtained according to the resistance value of the optical sensor, and then, different loads are controlled based on a level of the output voltage for light intensity in different ranges to perform corresponding operations. This application has high flexibility and strong adaptability, and can effectively broaden an application scope of a photosensitive device.

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Abstract: Methods and compositions for accurate identification of Parkinson's disease are disclosed. More particularly, the disclosure is directed to the determination of Parkinson's disease in ante-mortem tissue samples.

Abstract: In general, embodiments of the present invention provide systems, methods and computer readable media for a universal relevance service framework for ranking and personalizing items.

Abstract: An N-substituted imidazole carboxylate compound is of formula (I). In formula (I), C* is an R-type chiral carbon atom, R1 and R2 are independently selected from H, methyl, ethyl, cyclopropyl, cyclobutyl or isopropyl, or R1 and R2 form a C2˜5 alkylenyl group; R3 is a substituted or unsubstituted C1-18 saturated or unsaturated aliphatic hydrocarbon or aromatic hydrocarbon, in which the aliphatic hydrocarbon comprises a straight chain, branched chain or cyclic aliphatic hydrocarbyl. The compound or pharmaceutically acceptable salts thereof can be used to prepare central inhibitory drugs that exert sedative, hypnotic and/or anesthetic effects on humans or animals, and can produce rapid and reversible anesthetic effects, and can be rapidly metabolized into an inactive etomidate acid, and after drug withdrawal, the wake-up quality is good; and the body's corticosteroid function can be rapidly recovered after a single administration or continuous administration.

Abstract: The disclosure discloses a method for increasing the intracellular heme content of Escherichia coli and belongs to the field of metabolic engineering. In the disclosure, in E. coli, the gene mscS encoding a small conductance mechanically sensitive ion channel protein is knocked out, the gene aroG encoding 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase is knocked out, or the gene hemA encoding glutamyl-tRNA reductase is overexpressed. The constructed recombinant strain is cultured in an LB culture medium, and the heme content can reach 47.6 ?mol·L?1, which is significantly higher than that of a control strain. The recombinant strain has the value of wide application.

Abstract: A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

Abstract: A segment core and an axial flux motor. The segment core is formed by covering an SMC core (100, 100?) over an outer peripheral surface of a laminated core (200, 200?). An outer surface of the segment core, which can not be processed easily, is shaped by processing the easily shapeable SMC core (100, 100?). The entire structure of the laminated core (200, 200?) is relatively simple, and thus a mold for processing the laminated core (200, 200?) requires simpler specifications. Moreover, the mold can be used to perform processing easily, thereby reducing difficulties of processing the segment core. The segment core has better electromagnetic performance than a segment core solely using an SMC material, and has a higher core utilization rate than a segment core solely using a laminated core (200, 200?).

Abstract: A two-quaternary ammonium compound has a structural formula of formula (I). L1 is a C1 to C8 alkylene group; L2 is a C1 to C8 alkylene group; Z1 is nitro group or a halogen or methoxy group; Z2 is nitro group or a halogen or methoxy group; Z3 is nitro group or a halogen or methoxy group; R?H or a C1 to C6 alkyl group; a, b, and c are independently an integer from 0-5; and M is a pharmaceutically acceptable anion, such as a bromine ion, chlorine ion, sulfonate radical, etc. A stereoisomer or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate or eutectic of the compound of formula (I) forms a composition with a pharmaceutically acceptable carrier, or forms a compounded prescription with other active components, and the composition or compounded prescription may be used in the preparation of a muscle relaxant.

Abstract: Polymers and conjugates comprising polymers are disclosed herein. In some embodiments, the conjugates disclosed are suitable for use as detection probes in immunohistochemical assays, including multiplex immunohistochemical assays.

Abstract: The present disclosure discloses an LCD and a display device, and belongs to the field of display technologies. The LCD can include an LCD panel, a backlight module, a sealant, and a first polarizer. The backlight module is located at one side of the LCD panel. The first polarizer is located between the LCD panel and the backlight module. The backlight module has a first through hole thereon and the first polarizer has a second through hole thereon. The first through hole, the second through hole, and the LCD panel define a blind hole. The sealant is adhered to an inner wall of the blind hole, and the sealant is fixedly connected to the backlight module, the LCD panel, and the first polarizer by bonding.

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Abstract: A display panel and an electronic device are provided. The display panel comprises: a light-transmissive display area that comprises first pixel driving circuits; a first pixel array comprising an alternating light-emitting region. The alternating light-emitting region includes a plurality of sub-pixel groups, the plurality of sub-pixel groups include at least two colors, and each one of the plurality of sub-pixel groups includes at least one sub-pixel of the same color, at least two sub-pixel groups of the same color are connected in parallel to the same one of said first pixel driving circuits. The light-transmissive display includes a plurality of switching circuits. Each one of the plurality of switching circuits is connected with corresponding sub-pixel groups and first pixel driving circuit. The display panel also includes a control circuit connected with the plurality of the switching circuits and the first pixel driving circuits.

Abstract: A display apparatus includes a fixing component and a display screen having a first pixel region and a second pixel region. An aligning mark line is provided at a joint of the first and second pixel regions. A method for calibrating a display region of the display apparatus includes: capturing a connecting part of the display screen and the fixing component to obtain a first image; determining whether the aligning mark line is shifted with respect to the fixing component; and generating a correction instruction when the aligning mark line is shifted with respect to the fixing component, wherein the correction instruction includes activating a pixel row of the second pixel region where the aligning mark line is shifted with respect to the fixing component to substitute for a pixel row of the first pixel region shifted to a connecting region of the fixing component.

Abstract: Polymers and conjugates comprising polymers are disclosed herein. In some embodiments, the conjugates disclosed are suitable for use as detection probes in immunohistochemical assays, including multiplex immunohistochemical assays.

Abstract: Uses of a dual V region antibody-like protein or a fragment of a dual V region antibody-like region.

Abstract: A winding stator and an electric motor are provided, relating to the technical field of electric motors. The winding stator comprises at least one phase of windings, each phase of windings comprises at least one insulating carrying plate and at least one serpentine coil having a starting end and a terminating end, the at least one insulating carrying plate is provided with the serpentine coil, and the serpentine coil is arranged on the insulating carrying plate in a shape of a bent spiral sheet, wherein the serpentine coil comprises inward bent portions, outward bent portions and working portions, and wherein each of the working portion is in a fan-shaped sheet-like structure, an inner arc end of the fan-shaped sheet-like structure is connected with the inward bent portion, and an outer arc end of the fan-shaped sheet-like structure is connected with the outward bent portion.