Patents by Inventor Leland J. Chinn
Leland J. Chinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5162365Abstract: This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein the substituents are defined below. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: May 10, 1991Date of Patent: November 10, 1992Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Bipinchandra N. Desai, Richard A. Mueller
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Patent number: 5036105Abstract: This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R.sub.3 isa) ##STR2## wherein R.sub.4 is hydrogen or lower alkyl; b) ##STR3## c) ##STR4## wherein R.sub.6 and R.sub.7 may be the same or different and are alkyl of 1 to 4 carbon atoms; ord) ##STR5## and the pharmaceutically acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: October 14, 1988Date of Patent: July 30, 1991Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Bipinchandra N. Desai, Richard A. Mueller
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Patent number: 4801611Abstract: This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R.sub.3 is ##STR2## wherein R.sub.4 is hydrogen or lower alkyl; ##STR3## wherein R.sub.6 and R.sub.7 may be the same or different and are alkyl of 1 to 4 carbon atoms; or ##STR4## and the pharmaceuticlaly acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: May 7, 1987Date of Patent: January 31, 1989Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Bipinchandra N. Desai, Richard A. Mueller
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Patent number: 4694018Abstract: The compounds of the present invention comprise substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives thereof represented by the formula: ##STR1## wherein: R represents hydroxy, alkoxy of from 1 to 6 carbon atoms, inclusive, or amino; R.sup.1 represents hydrogen or acyl of from 2 to 7 carbon atoms, inclusive; and X represents hydrogen, halogen, hydroxy or alkoxy of from 1 to 6 carbon atoms, inclusive. The compounds of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: November 29, 1985Date of Patent: September 15, 1987Assignee: G. D. Serale & Co.Inventor: Leland J. Chinn
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Patent number: 4687864Abstract: The present invention describes 5-fluoro-3-oxaprostacyclin (PGI.sub.2) derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates. ##STR1## wherein R.sup.1 is: (a) Na, K, or 1/2 Ca, or other pharmaceutically acceptable cation(b) NR.sup.3 .sub.2 with the adjacent connecting oxygen omitted, where R.sup.3 =H, methyl, ethyl, isopropyl or a combination of these groups;(c) Alkyl of 1 to 6 carbon atoms, either branched or straight chain(d) Hydrogenwherein OH on carbon 15 is optionally on carbon 16;wherein X=OCH.sub.3 or OC.sub.2 H.sub.5 when neither C.sub.5 -C.sub.6 or C.sub.6 -C.sub.7 is a double bond and nothing if C.sub.5 -C.sub.6 or C.sub.6 -C.sub.7 is a double bond;wherein R.sup.Type: GrantFiled: September 18, 1985Date of Patent: August 18, 1987Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Leland J. Chinn, Kurt J. Rorig
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Patent number: 4579958Abstract: The present invention describes 5-fluoro-3-oxa-prostacyclin (PGI.sub.2) derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates. ##STR1## wherein R.sup.1 is: (a) Na, K, or 1/2 Ca, or other pharmaceutically acceptable cation(b) NR.sup.3.sub.2, where R.sup.3 .dbd.H, methyl, ethyl, isopropyl or a combination of these groups;(c) Alkyl of 1 to 6 carbon atoms, either branched or straight chain(d) Hydrogenwherein OH on carbon 15 is optionally on carbon 16; wherein X.dbd.H, OCH.sub.3 or OC.sub.2 H.sub.5 when neither C.sub.5 -C.sub.6 or C.sub.6 -C.sub.7 is a double bond and nothing if C.sub.5 -C.sub.6 or C.sub.6 -C.sub.7 is a double bond;wherein R.sup.Type: GrantFiled: December 23, 1983Date of Patent: April 1, 1986Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Leland J. Chinn, Kurt J. Rorig
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Patent number: 4459235Abstract: The invention relates to novel 2-cyanosteroids of Formula I which are useful for the induction of menses and the termination of pregnancy.Type: GrantFiled: March 3, 1983Date of Patent: July 10, 1984Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Karlene W. Salamon
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Patent number: 4388311Abstract: The invention relates to a method for the induction of menses or the termination of pregnancy by administration of a compound of Formula IV.Type: GrantFiled: May 6, 1982Date of Patent: June 14, 1983Assignee: G. D. Searle & Co.Inventor: Leland J. Chinn
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Patent number: 4349474Abstract: The invention relates to novel 2-cyanosteroids of Formula I which are useful for the induction of menses and the termination of pregnancy.Type: GrantFiled: July 27, 1981Date of Patent: September 14, 1982Assignee: G. D. Searle & Co.Inventor: Leland J. Chinn
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Patent number: 4010169Abstract: Preparation and the antilipogenic utility of (E)-4-hydroxy-11,15-dioxoprosta-8(12),13-dien-1-oic acid .gamma.-lactones are disclosed.Type: GrantFiled: March 10, 1976Date of Patent: March 1, 1977Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Karlene W. Salamon
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Patent number: 3954844Abstract: Preparation and the antispasmodic utility of (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid and esters are disclosed.Type: GrantFiled: January 3, 1975Date of Patent: May 4, 1976Assignee: G. D. Searle & Co.Inventors: Frank B. Colton, Leland J. Chinn