Leon Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: The present invention relates to the use of antagonists of the mTOR signaling pathway and its constituent members (e.g., antagonists of MAPKAP) for the treatment, amelioration, and diagnosis of PI3K/AKT/mTOR-related disorders, e.g., cancers. The present invention also relates to methods of using modulators of mTOR (e.g., modulators of MAPKAP) for the treatment, amelioration, and diagnosis of PI3K/AKT/mTOR-related disorders, e.g., cancers. Assays for the identification of modulators of mTOR, MAPKAP, and hVPS34 are also provided.
August 28, 2007
October 15, 2009
Peter Finan, Jeff Mac Keigan, Leon Murphy, Paul Leslie Nicklin, Ellen Triantafellow
Abstract: The present invention relates to novel uses and reagents relating to apoptosis-related disorders. In particular, modulation of PI3K class II? activity is shown to influence apoptosis, and PI3K class II? is thought to be cellular survival factors. Based on these findings the present invention provides therapeutic methods and pharmaceutical compositions useful for the treatment of apoptosis-related disorders. In addition, PI3K class II? is provided as a target for the development of therapeutics. Accordingly, the invention provides screening methods for identifying candidate compounds that modulate PI3K class II? activity and may therefore be used to treat apoptosis-related disorders such as cardiovascular disorders, autoimmune disorders, neurodegenerative disorders, and cancer.
November 20, 2006
July 26, 2007
Jeff MacKeigan, Leon Murphy, Peter Finan, Ellen Triantafellow
Abstract: A support device for supporting small articles. The device is adapted to be secured to a supporting panel such as the windshield of an automobile. The device is formed of two planar members, one of which is adapted to be secured to a support panel member. The two planar members are interconnected by means of a hinge whereby the second planar member may be rotated about a hinge pin to lie at any desired angle with respect to the first planar member. Thus the first planar member may be secured to a windshield or a similar supporting surface which is disposed at an angle with respect to the vertical, whereby the second member may be rotated to be at a desired orientation, for instance horizontal. The hinge includes a fastner to tightly press the hinge knuckles together to maintain the orientation of the two planar members with respect to each other.