Patents by Inventor Leonard Katz

Leonard Katz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11505791
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: November 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Publication number: 20220025380
    Abstract: This present invention provides a genetically modified host cell, such as an E. coli host cell, capable of producing or overproducing a hydroxylated methyl ketone (HMK), such as an omega-hydroxy and/or omega-1-hydroxy methyl ketone.
    Type: Application
    Filed: July 22, 2021
    Publication date: January 27, 2022
    Inventors: Robert W. Haushalter, Ee-Been Goh, Jorge Alonso-Gutierrez, Leonard Katz, Jay D. Keasling
  • Patent number: 10760069
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 1, 2020
    Assignee: The Regents of the University of California
    Inventors: Andrew R. Hagen, Sean Poust, Leonard Katz, Jay D. Keasling
  • Publication number: 20200270597
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: December 2, 2019
    Publication date: August 27, 2020
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Patent number: 10494625
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: December 3, 2019
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Publication number: 20190345462
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
    Type: Application
    Filed: January 24, 2019
    Publication date: November 14, 2019
    Inventors: Satoshi Yuzawa, Leonard Katz, Jay D. Keasling
  • Patent number: 10233431
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: March 19, 2019
    Assignee: The Regents of the University of California
    Inventors: Satoshi Yuzawa, Leonard Katz, Jay D. Keasling
  • Publication number: 20180273930
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid.
    Type: Application
    Filed: January 10, 2018
    Publication date: September 27, 2018
    Applicant: The Regents of the University of California
    Inventors: Andrew R. Hagen, Sean Poust, Leonard Katz, Jay D. Keasling
  • Patent number: 9856461
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an ?-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the ?-olefin.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: January 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Leonard Katz, Eric J. Steen, Jay D Keasling
  • Publication number: 20170015990
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: May 2, 2016
    Publication date: January 19, 2017
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Patent number: 9334514
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: May 10, 2016
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Publication number: 20160068827
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an ?-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the ?-olefin.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 10, 2016
    Inventors: Jeffrey L. Fortman, Leonard Katz, Eric J. Steen, Jay D. Keasling
  • Publication number: 20150307855
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
    Type: Application
    Filed: February 26, 2015
    Publication date: October 29, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Satoshi Yuzawa, Leonard Katz, Jay D. Keasling
  • Patent number: 9040282
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: May 26, 2015
    Assignee: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L Fortman, Jay D Keasling
  • Patent number: 8852902
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host cell of the present invention, and culturing said host cell in a suitable culture medium such that the trimethylpentanoic acid is produced, optionally isolating the trimethylpentanoic acid, and optionally, reducing the isolated trimethylpentanoic acid into a trimethylpentanol or an iso-octane.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: October 7, 2014
    Assignee: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L. Fortman, Jay D. Keasling
  • Publication number: 20140030789
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
    Type: Application
    Filed: September 26, 2013
    Publication date: January 30, 2014
    Applicant: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L. Fortman, Jay D. Keasling
  • Patent number: 8569023
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: October 29, 2013
    Assignee: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L Fortman, Jay D Keasling
  • Publication number: 20130280766
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: October 31, 2011
    Publication date: October 24, 2013
    Applicant: The Regents of the Unversity of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Publication number: 20130267696
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an ?-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the ?-olefin.
    Type: Application
    Filed: September 28, 2011
    Publication date: October 10, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey L. Fortman, Leonard Katz, Eric J. Steen, Jay D. Keasling
  • Patent number: 8420833
    Abstract: The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: April 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L Fortman, Jay D Keasling