Abstract: The fullness and length of eyelashes and eyebrows can be enhanced by topical application of a composition comprising at least one peptide copper complex to an area of skin at the base of the eyelashes and eyebrows. Disclosed are compositions and methods for such treatment.

Abstract: Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol derivative, or a mixture thereof and methods wherein the composition further comprises active agents selected from active drug substances, emollients, sunscreen agents, skin lightening agents, skin protectants, skin conditioning agents, humectants, and mixtures thereof.

Abstract: Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol derivative, or a mixture thereof and methods wherein the composition further comprises active agents selected from active drug substances, emollients, sunscreen agents, skin lightening agents, skin protectants, skin conditioning agents, humectants, and mixtures thereof.

Abstract: A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating psoriasis.

Abstract: A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating rosacea.

Abstract: Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to microbial growth, when the preservative is selected to be a non-formaldehyde-donating preservative. In other embodiments, the present invention is directed to such compositions that are formulated for use as pharmaceuticals and cosmetic products, and to medical devices comprising a disclosed composition. In another aspect, the present invention is also directed to a method for imparting to a composition comprising at least one peptide copper complex, chemical stability as well as resistance and/or toxicity to microbial growth, where the method comprises incorporating a non-formaldehyde-donating preservative in the composition.

Abstract: A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating rosacea.

Abstract: A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating psoriasis.

Abstract: A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating rosacea.

Abstract: A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating psoriasis.

Abstract: Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to microbial growth, when the preservative is selected to be a non-formaldehyde-donating preservative. In other embodiments, the present invention is directed to such compositions that are formulated for use as pharmaceuticals and cosmetic products, and to medical devices comprising a disclosed composition. In another aspect, the present invention is also directed to a method for imparting to a composition comprising at least one peptide copper complex, chemical stability as well as resistance and/or toxicity to microbial growth, where the method comprises incorporating a non-formaldehyde-donating preservative in the composition.

Abstract: Novel compositions having anti-oxidant, anti-inflammatory and/or cosmetic utility for a mammal, combine at least one peptide copper complex and at least one phytochemical compound. More particularly, disclosed are such novel compositions where the phytochemical compound is a polyphenol or a carotenoid, the polyphenol being a flavanoid, a flavonoid, a flavonoid derivative, a flavolignan, a polyphenolic rhizome, or a mixture thereof. Compositions for topical application are disclosed that include additives such as emollients, sunscreen agents, skin protectants, skin conditioning agents, and humectants. Also disclosed are methods, employing such compositions, for enhancing or restoring the resistance of a mammal to oxidative or inflammatory damage, for accelerating wound healing, for cosmetically healing mammalian skin, and for stimulating hair growth, or preventing or treating hair loss.

Abstract: Disclosed are compositions, useful for stimulating hair growth in warm-blooded animals in need thereof, that combine at least one peptide copper complex and Minoxidil. The disclosed compositions may be formulated so as to be suitable for topical application or for intradermal injection to areas of skin in need thereof. Also disclosed are methods for stimulating hair growth to thereby treat various hair growth afflictions, such as androgenetic alopecia, alopecia areata, or secondary alopecia. Generally, the disclosed methods comprise applying, topically or via intradermal injection, a stimulatory effective amount of a disclosed composition to an area of a patient's skin in need thereof. In one embodiment, the disclosed method employs such application in a continued and periodic fashion to arrest and/or reverse androgenetic alopecia.

Abstract: Novel compositions capable of inhibiting the degradation of extracellular matrices of warm-blooded animals, including humans, and promoting the production of proteins thereof, combine at least one metalloproteinase inhibitor, which may be a matrix metalloproteinase inhibitor, and at least one peptide copper complex. Also disclosed are methods that utilize the disclosed compositions, by administering to warm-blooded animals effective amounts thereof orally, parenterally, or topically, for treating arthritis and other inflammatory conditions, enhancing wound and bone healing, treating skin diseases, treating cosmetic defects of the skin, or stimulating hair growth.

Abstract: Novel compositions for treating skin defects and effecting desired cosmetic changes by way of soft tissue augmentation, combine at least one soft tissue filler and at least one peptide copper complex. Typically, the compositions are suitable for injection into skin areas in need of such treatment. Also disclosed are methods for treating skin defects and effecting desired cosmetic changes. One disclosed method employs the disclosed compositions wherein the soft tissue fillers and peptide copper complexes are combined. Other disclosed methods combine the soft tissue fillers and peptide copper complexes during application of the method itself by way of injection, or a combination of injection and topical application, of the fillers and complexes.

Abstract: Compositions are formed by adding at least one amino acid to an aqueous solution of at least one peptide copper complex, and disclosed methods impart to solutions of peptide copper complexes, chemical stability and resistance to precipitation of the complexes through the addition of at least one of certain amino acids thereto. Also disclosed are compositions comprising at least one peptide copper complex and at least one of certain amino acids, as well as compositions further comprising one or more preservatives to provide thereto resistance to microbial attack and toxicity to microbes. Medical devices, pharmaceuticals and cosmetics comprising such compositions are also disclosed.

Abstract: Compositions, generally useful for preserving the skin and/or improving its health and appearance, comprise a peptide copper complex and retinol, a retinol derivative, or a mixture thereof. In another embodiment, the disclosed compositions further comprise additives, including emollients, sunscreen agents, skin protectants, skin conditioning agents, and/or humectants. Also disclosed is a method for treating skin to accomplish such preservation and/or improvement thereof, where the method comprises the step of topically applying a disclosed composition to an area of skin in need of such treatment.

Abstract: Methods for treating hyperpigmentation of skin employ topical application of compositions to skin in need thereof, where the compositions comprise at least one peptide copper complex, or at least one peptide copper complex in combination with retinol, at least one retinol derivative, or a mixture thereof. Also disclosed are methods that use such compositions further comprising active agents selected from active drug substances, emollients, sunscreen agents, skin-lightening agents, skin protectants, skin conditioning agents, and humectants.

Abstract: Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides chelated to copper at a molar ratio ranging from about 1:1 to 3:1, with the second position of the peptide from the amino terminus being histidine, arginine or a derivative thereof. The peptide-copper complexes may be formulated for administration by, for example, topical application or injection. Any affliction associate with hair loss, including hair loss associated with both androgenetic and secondary alopecia, may be treated with the peptide-copper complexes of this invention.

Abstract: Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides chelated to copper at a molar ratio ranging from about 1:1 to 3:1, with the second position of the peptide from the amino terminus being histidine, arginine or a derivative thereof. The peptide-copper complexes may be formulated for administration by, for example, topical application or injection. Any affliction associate with hair loss, including hair loss associated with both androgenetic and secondary alopecia, may be treated with the peptide-copper complexes of this invention.