Patents by Inventor Leping Li

Leping Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060270651
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Application
    Filed: February 1, 2006
    Publication date: November 30, 2006
    Applicant: AMGEN INC.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Mihalic, Serena Cutler
  • Patent number: 7125885
    Abstract: The present invention provides compounds having the formula: wherein R1, R2, R, R? and the subscript p are described herein. The compounds are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorder, obesity, anxiety disorders and mood disorders are also provided.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: October 24, 2006
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Mike Lizarzaburu, Jeffrey Thomas Mihalic, Stephen Joseph Shuttleworth
  • Publication number: 20060199796
    Abstract: The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.
    Type: Application
    Filed: August 12, 2005
    Publication date: September 7, 2006
    Applicant: Amgen Inc.
    Inventors: Xi Chen, Xiaoqi Chen, Richard Connors, Kang Dai, Ying Fu, Juan Jaen, Yong-Jae Kim, Leping Li, Mike Lizarzaburu, Jeffrey Mihalic, Stephen Shuttleworth
  • Patent number: 7053234
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: May 30, 2006
    Assignee: Amgen Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • Patent number: 7045527
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: May 16, 2006
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Ying Fu, Leping Li, Jeffrey T. Mihalic
  • Patent number: 6989683
    Abstract: Improved endpoint detection is obtained for wet etch and/or other chemical processes involving in situ measurement of bath impedance. The endpoint detection uses a measurement apparatus having a measurement circuit with a capacitor designed to alter the phase angle of the circuit. The capacitor is preferably a variable capacitor which is used to set the initial phase angle of the measurement circuit to about zero. The methods using the improved detection enable etch to be more precisely controlled even under conditions where noise would otherwise adversely impact determination of the endpoint.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: January 24, 2006
    Assignee: International Business Machines Corporation
    Inventors: Leping Li, Steven G. Barbee
  • Publication number: 20050197048
    Abstract: A method for manufacturing a workpiece and a torque transducer module for material removal techniques, are disclosed, where machining friction varies in dependency of machining depth and the torque/deformation of a shaft is monitored for controlling material removal. The module has a body extending along a central axis and two end portions. Each end portion is part of an axial mount for a respective part to be axially mounted thereto. The module also includes a strain gage sensor arrangement with at least one electric output.
    Type: Application
    Filed: March 4, 2004
    Publication date: September 8, 2005
    Inventors: Leping Li, Werner Moser, Yingru Gu
  • Publication number: 20050148617
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Application
    Filed: August 26, 2004
    Publication date: July 7, 2005
    Inventors: Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Mike Lizarzaburu, Jeffrey Mihalic, Stephen Shuttleworth
  • Patent number: 6906069
    Abstract: The invention provides compounds, compositions and methods for modulating the effects of LXR? in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR? function and as pharmacologically active agents. The compounds and compositions find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: June 14, 2005
    Assignee: Amgen Inc.
    Inventors: Leping Li, Julio C. Medina, Bei Shan
  • Patent number: 6899784
    Abstract: An apparatus for measuring ammonia gas concentration in an ongoing chemical mechanical polishing (CMP) cycle utilizing an acidic CMP slurry, having the following components: a. A transferring means to collect a sample of the acidic CMP slurry; b. A converting means to convert the acidic CMP slurry to a basic slurry; c. A measuring means to measure the ammonia gas present in the basic slurry; d. A detection means to signal the end of an ongoing CMP cycle.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: May 31, 2005
    Assignees: International Business Machines Corporation, EcoPhysics AG
    Inventors: Leping Li, Steven G. Barbee, Scott R. Cline, James A. Gilhooly, Walter Imfeld, Werner Moser, Adrian Siegrist, Heinz Stunzi, Xinhui Wang, Cong Wei
  • Patent number: 6878629
    Abstract: An apparatus for measuring ammonia gas concentration in an ongoing mechanical polishing (CMP) cycle utilizing an acidic CMP slurry, having the following components: a. A transferring means to collect a sample of the acidic CMP slurry; b. A converting means to convert the acidic CMP slurry to a basic slurry; c. A measuring means to measure the ammonia gas present in the basic slurry; d. A detection means to signal the end of an ongoing CMP cycle.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: April 12, 2005
    Assignee: International Business Machines Corporation
    Inventors: Leping Li, Steven G. Barbee, Scott R. Cline, James A. Gilhooly, Xinhui Wang, Cong Wei
  • Patent number: 6858619
    Abstract: Compounds useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor are provided that have the formula: wherein A and B are CR?; V is either a bond and W is —N(R?)—, or else V is —N(R?)— and W is a bond; Z is —N(R)—CH2—; R1, R2, R3, R4, R?, R?, and R are as defined herein; the subscript n is an integer from 0 to 8; and ?is a benzene ring. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: February 22, 2005
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Shugui Huang, Leping Li, Jeffrey Thomas Mihalic
  • Patent number: 6843880
    Abstract: Improved endpoint detection is obtained for wet etch and/or other chemical processes involving in situ measurement of bath impedance. The endpoint detection uses a measurement apparatus having a measurement circuit with a capacitor designed to alter the phase angle of the circuit. The capacitor is preferably a variable capacitor which is used to set the initial phase angle of the measurement circuit to about zero. The methods using the improved detection enable etch to be more precisely controlled even under conditions where noise would otherwise adversely impact determination of the endpoint.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: January 18, 2005
    Assignee: International Business Machines Corporation
    Inventors: Leping Li, Steven G. Barbee
  • Publication number: 20050006027
    Abstract: Improved endpoint detection is obtained for wet etch and/or other chemical processes involving in-situ measurement of bath impedance. The endpoint detection uses a measurement apparatus having a measurement circuit with a capacitor designed to alter the phase angle of the circuit. The capacitor is preferably a variable capacitor which is used to set the initial phase angle of the measurement circuit to about zero. The methods using the improved detection enable etch to be more precisely controlled even under conditions where noise would otherwise adversely impact determination of the endpoint.
    Type: Application
    Filed: August 4, 2004
    Publication date: January 13, 2005
    Inventors: Leping Li, Steven Barbee
  • Patent number: 6835117
    Abstract: A chemical-mechanical polishing (CMP) system and method includes pumping polishing slurry from a CMP apparatus through a sampling tube to an endpoint detection apparatus during a polishing operation, and flushing the sampling tube while a polishing operation is not in progress. The flushing of the sampling tube is commenced in accordance with a control signal from the endpoint detection apparatus terminating the polishing operation; the flushing is terminated in accordance with a starting signal to the CMP apparatus. The pump, which pumps a sample of slurry into the endpoint detection apparatus, continuously pumps slurry and/or water. Clogging of the slurry sampling tube is thus eliminated, thereby ensuring robust operation of the CMP apparatus. Contamination of the sampling tube is also avoided, so that the system may reliably provide sensitive endpoint detection and process control, even when a film of low pattern density is polished.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: December 28, 2004
    Assignee: International Business Machines Corporation
    Inventors: Xinhui Wang, Leping Li, Yingru Gu, Hung-Chin Guthrie
  • Publication number: 20040235911
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Application
    Filed: June 25, 2004
    Publication date: November 25, 2004
    Applicant: Tularik Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • Patent number: 6809104
    Abstract: Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subscript n are as described herein, are provided, which are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: October 26, 2004
    Assignee: Tularik Inc.
    Inventors: Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Mike Lizarzaburu, Jeffrey Thomas Mihalic, Stephen Joseph Shuttleworth
  • Patent number: 6780858
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: August 24, 2004
    Assignee: Tularik Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • Publication number: 20040147538
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Application
    Filed: November 6, 2003
    Publication date: July 29, 2004
    Inventors: Xi Chen, Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Jeffrey Thomas Mihalic
  • Publication number: 20040142956
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
    Type: Application
    Filed: September 23, 2003
    Publication date: July 22, 2004
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Ying Fu, Leping Li, Jeffrey T. Mihalic