Patents by Inventor Leroy S. Hersh

Leroy S. Hersh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidized styrenic polymers for DNA binding
    Patent number: 6391655
    Abstract: A method of immobilizing aminated DNA to a substrate surface is provided for use in DNA hybridization assays. The surface can be widely employed in a variety of molded laboratory products including multiwell plates, cell culture dishes, and biological containers. The method comprises the steps of providing a polystyrene substrate having a surface content of between 0.3 and 4.0% atomic percent oxygen, and attaching amine modified oligonucleotide to the surface of the substrate. A resultant product comprising a polystyrene substrate having a surface oxygen content of between 0.3 and 4.0% atomic percent, and a plurality of amine modified oligonucleotides directly attached to the surface of the substrate, is also disclosed.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: May 21, 2002
    Assignee: Corning Incorporated
    Inventors: Dana C. Bookbinder, Leroy S. Hersh, Xinying Xie
  • Method of attaching dialdehyde starch to a surface and products produced by that method
    Patent number: 5563215
    Abstract: A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: October 8, 1996
    Assignee: Corning Incorporated
    Inventors: Marie D. Bryhan, Leroy S. Hersh, Frances M. Smith
  • Method of attaching dialdehyde starch to a surface and products produced by that method
    Patent number: 5281660
    Abstract: A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: January 25, 1994
    Assignee: Corning Incorporated
    Inventors: Marie D. Bryhan, Leroy S. Hersh, Frances M. Smith
  • Method for making semi-permeable polymer membranes
    Patent number: 5275766
    Abstract: A method for making a semi-permeable microporous polymer sheet, useful as a separation membrane or the like, including extruding a melt-blended mixture of a high-temperature thermoplastic polymer and a leachable glass to form sheet and then leaching the glass from the sheet to leave a microporous relict polymer network, wherein the permeability of the sheet is improved by plasma-etching the surface of the sheet before or after leaching. Hydrophilic or hydrophobic porous membranes may be provided.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: January 4, 1994
    Assignee: Corning Incorporate
    Inventors: Kishor P. Gadkaree, Leroy S. Hersh
  • Solid phase radioimmunoassay of digoxin
    Patent number: 3933997
    Abstract: Clinically significant concentrations of digoxin can be determined by reacting an unknown amount of digoxin, a known amount of labelled digoxin, and a composite consisting of anti-digoxin antibodies coupled through an intermediate silane to magnetically responsive particles; magnetically separating the immunochemical complexes formed thereby, counting the radioactivity of either the separated products or remaining solution, and relating the count to a standard curve.
    Type: Grant
    Filed: March 1, 1974
    Date of Patent: January 20, 1976
    Assignee: Corning Glass Works
    Inventors: Leroy S. Hersh, Sidney Yaverbaum