Patents by Inventor Leszek Rychlewski

Leszek Rychlewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9315552
    Abstract: The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumor cells.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: April 19, 2016
    Assignee: BIOINFOBANK SP. Z O. O.
    Inventors: Anna Bujko, Magdalena Lukasiak, Jaroslaw Dastych, Miroslawa Skupinska, Ewelina Rodakowska, Leszek Rychlewski
  • Patent number: 8946400
    Abstract: The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: February 3, 2015
    Assignees: Instytut Chemii Bioorganicznej Pan, Uniwersytet Medyczny Im.Karola Marcinkowskiego, Bioinfobank Sp.Z O.O.
    Inventors: Jan Barciszewski, Miroslawa Barciszewska, Leszek Rychlewski, Eliza Wyszko, Iwona Gawronska, Ryszard Zukiel, Katarzyna Rolle, Stanisaw Nowak
  • Publication number: 20140005362
    Abstract: The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumour cells.
    Type: Application
    Filed: December 29, 2011
    Publication date: January 2, 2014
    Inventors: Anna Bujko, Magdalena Lukasiak, Jaroslaw Dastych, Miroslawa Skupinska, Ewelina Rodakowska, Leszek Rychlewski
  • Publication number: 20110275537
    Abstract: Immune-chips, which are arrays of peptides probes are used to obtain a pattern which characterizes the global immune reactivity status of the human or other organism, are described. The peptide probes participate in immune reactions with antibodies and immune receptors of the investigated organisms to generate an immune pattern on the chip, which are detected and stored as patterns in databases. The patterns are then compared with other patterns observed with the same array and obtained under physiological, pathological and experimental conditions from the same or other organisms. The comparison is used to classify the state of the investigated organisms based on similarity to other observed states. The immune chips and the obtained patterns can be used for clinical diagnosis and biological studies, such as the investigation of similarities between physiological, pathological or experimental processes.
    Type: Application
    Filed: July 19, 2011
    Publication date: November 10, 2011
    Inventors: Leszek Rychlewski, Jaroslaw Dastych
  • Patent number: 7923578
    Abstract: The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological properties it might be use as a composition for skin having excellent anti-aging effect to prevent the sagging of skin and loss of luster.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: April 12, 2011
    Assignee: Instytut Chemii Bioorganicznej Pan
    Inventors: Jan Barciszewski, Leszek Rychlewski, Lech Celewicz, Krzysztof Ciszewski, Eliza Wyszko, Katarzyna Rolle
  • Publication number: 20100184620
    Abstract: Immune-chips, which are arrays of peptides probes are used to obtain a pattern which characterizes the global immune reactivity status of the human or other organism, are described. The peptide probes participate in immune reactions with antibodies and immune receptors of the investigated organisms to generate an immune pattern on the chip, which are detected and stored as patterns in databases. The patterns are then compared with other patterns observed with the same array and obtained under physiological, pathological and experimental conditions from the same or other organisms. The comparison is used to classify the state of the investigated organisms based on similarity to other observed states. The immune chips and the obtained patterns can be used for clinical diagnosis and biological studies, such as the investigation of similarities between physiological, pathological or experimental processes.
    Type: Application
    Filed: January 21, 2010
    Publication date: July 22, 2010
    Inventors: Leszek RYCHLEWSKI, Jaroslaw Dastych
  • Publication number: 20100076053
    Abstract: The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.
    Type: Application
    Filed: July 30, 2007
    Publication date: March 25, 2010
    Applicants: INSTYTUT CHEMII BIOORGANICZNEJ PAN, BIOINFOBANK SP. Z O.O., UNIWERSYTET MEDYCZNY IM.KAROLA MARCINKOWSKIEGO
    Inventors: Jan Barciszewski, Miroslawa Barciszewska, Leszek Rychlewski, Eliza Wyszko, Iwona Gawronska, Ryszard Zukiel, Katarzyna Rolle, Stanisaw Nowak
  • Publication number: 20080249334
    Abstract: The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological properties it might be use as a composition for skin having excellent anti-aging effect to prevent the sagging of skin and loss of luster.
    Type: Application
    Filed: October 18, 2006
    Publication date: October 9, 2008
    Applicant: INSTYTUT CHEMII BIOORGANICZNEJ PAN
    Inventors: Jan Barciszewski, Leszek Rychlewski, Lech Celewicz, Krzysztof Ciszewski, Eliza Wyszko, Katarzyna Rolle