Patents by Inventor Lex Evan Flagel
Lex Evan Flagel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230203489Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: March 14, 2023Publication date: June 29, 2023Applicant: Monsanto Technology LLCInventors: Jodi Lynn BEATTIE, Michael John CRAWFORD, Brian Donovan EADS, Lex Evan FLAGEL, Mahak KAPOOR, Christina Marie TAYLOR
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Publication number: 20230035621Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: June 2, 2022Publication date: February 2, 2023Applicant: Monsanto Technology LLCInventors: Jodi Lynn BEATTIE, Michael John CRAWFORD, Brian Donovan EADS, Lex Evan FLAGEL, Mahak KAPOOR, Christina Marie TAYLOR
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Publication number: 20220361428Abstract: Methods are provided for genome editing. On example method includes editing a genome sequence of an organism with multiple edits simultaneously without precise knowledge of a phenotypic effect of each individual one of the multiple edits, wherein the multiple edits are selected based on a prediction of an aggregate phenotypic effect of the multiple edits on a phenotypic trait. The method also includes aggregating the multiple edits into multi-dimensional pools, whereby phenotypic effects of contrasting pools of edits are compared to ascertain which of the multiple edits are most likely to be causing large phenotypic effects while eliminating need to evaluate each edit separately.Type: ApplicationFiled: July 26, 2022Publication date: November 17, 2022Inventors: David Vincent BUTRUILLE, Lex Evan FLAGEL
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Patent number: 11377667Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: GrantFiled: February 4, 2020Date of Patent: July 5, 2022Assignee: Monsanto Technology LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Patent number: 11186837Abstract: The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through RNA interference.Type: GrantFiled: December 8, 2016Date of Patent: November 30, 2021Assignee: Monsanto Technology LLCInventors: James A. Baum, Lex Evan Flagel, Gerrit Cornelis Segers, James K. Roberts
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Publication number: 20210230594Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: March 11, 2021Publication date: July 29, 2021Applicant: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn BEATTIE, Michael John CRAWFORD, Brian Donovan EADS, Lex Evan FLAGEL, Mahak KAPOOR, Christina Marie TAYLOR
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Patent number: 10968449Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: GrantFiled: January 21, 2016Date of Patent: April 6, 2021Assignee: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Publication number: 20200165627Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: February 4, 2020Publication date: May 28, 2020Applicant: Monsanto Technology LLCInventors: Jodi Lynn BEATTIE, Michael John CRAWFORD, Brian Donovan EADS, Lex Evan FLAGEL, Mahak KAPOOR, Christina Marie TAYLOR
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Patent number: 10597676Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: GrantFiled: November 21, 2017Date of Patent: March 24, 2020Assignee: Monsanto Technology LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Publication number: 20180285520Abstract: Exemplary systems and methods for selecting from population of candidate edits and predicting an aggregate effect of the candidate edits are disclosed. One exemplary method includes identifying a population of candidate edits to a genomic sequence of said organism and ranking each of the candidate edits based on a predicted ability of each candidate edit to affect a trait of interest in said organism. The exemplary method further includes selecting one or more of the candidate edits based on the ranking and predicting, by the computing device, an aggregate effect of the selected one or more of the candidate edits for the trait of interest when expressed by a specimen of the organism having a genomic sequence and edited according to the selected one or more of the candidate edits, as compared to an unedited specimen of the organism.Type: ApplicationFiled: March 29, 2018Publication date: October 4, 2018Inventors: David Vincent BUTRUILLE, Lex Evan FLAGEL
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Publication number: 20180066278Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: November 21, 2017Publication date: March 8, 2018Applicant: Monsanto Technology LLCInventors: Jodi Lynn BEATTIE, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Publication number: 20180002691Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: January 21, 2016Publication date: January 4, 2018Applicant: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn BEATTIE, Michael John CRAWFORD, Brian Donovan EADS, Lex Evan FLAGEL, Mahak KAPOOR, Christina Marie TAYLOR
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Patent number: 9856495Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: GrantFiled: January 29, 2015Date of Patent: January 2, 2018Assignee: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Patent number: 9850496Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: GrantFiled: January 22, 2015Date of Patent: December 26, 2017Assignee: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Patent number: 9777288Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: GrantFiled: July 18, 2014Date of Patent: October 3, 2017Assignee: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Publication number: 20170183684Abstract: The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through RNA interference.Type: ApplicationFiled: December 8, 2016Publication date: June 29, 2017Inventors: James A. Baum, Renata Bolognesi, Lex Evan Flagel, Gerrit Cornelis Segers, Larry A. Gilbertson, David K. Kovalic, Thomas J. LaRosa, Maolong Lu, Tichafa R. I. Munyikwa, James K. Roberts, Wei Wu, Bei Zhang
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Publication number: 20160230185Abstract: The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through RNA interference.Type: ApplicationFiled: March 12, 2014Publication date: August 11, 2016Applicant: Monsanto Technology LLCInventors: James A. Baum, Renata Bolognesi, Lex Evan Flagel, Gerrit Cornelis Segers
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Publication number: 20150240258Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: January 22, 2015Publication date: August 27, 2015Applicant: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Publication number: 20150203867Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: January 29, 2015Publication date: July 23, 2015Applicant: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor
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Publication number: 20150143580Abstract: Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.Type: ApplicationFiled: July 18, 2014Publication date: May 21, 2015Applicant: MONSANTO TECHNOLOGY LLCInventors: Jodi Lynn Beattie, Michael John Crawford, Brian Donovan Eads, Lex Evan Flagel, Mahak Kapoor, Christina Marie Taylor