Patents by Inventor Lex M. Cowsert

Lex M. Cowsert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030220282
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Application
    Filed: February 7, 2003
    Publication date: November 27, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Sanjay Bhanot, Lex M. Cowsert, Jacqueline R. Wyatt, Brett P. Monia, Madeline M. Butler, Robert McKay, Susan M. Freier
  • Publication number: 20030211609
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of ARA70. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding ARA70. Methods of using these compounds for modulation of ARA70 expression and for treatment of diseases associated with expression of ARA70 are provided.
    Type: Application
    Filed: October 25, 2002
    Publication date: November 13, 2003
    Inventors: Lex M. Cowsert, Jacqueline Wyatt
  • Publication number: 20030212020
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Macrophage migration inhibitory factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Macrophage migration inhibitory factor. Methods of using these compounds for modulation of Macrophage migration inhibitory factor expression and for treatment of diseases associated with expression of Macrophage migration inhibitory factor are provided.
    Type: Application
    Filed: October 23, 2002
    Publication date: November 13, 2003
    Inventors: Susan F Murray, Lex M Cowsert, Jacqueline Wyatt
  • Publication number: 20030211607
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
    Type: Application
    Filed: November 21, 2002
    Publication date: November 13, 2003
    Inventors: C. Frank Bennett, Elizabeth J. Ackermann, Eric E. Swayze, Lex M. Cowsert
  • Publication number: 20030207831
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric repeat binding factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Telomeric repeat binding factor 2. Methods of using these compounds for modulation of Telomeric repeat binding factor 2 expression and for treatment of diseases associated with expression of Telomeric repeat binding factor 2 are provided.
    Type: Application
    Filed: May 28, 2002
    Publication date: November 6, 2003
    Inventors: Brett P. Monia, Lex M. Cowsert
  • Publication number: 20030199467
    Abstract: This invention provides compositions and methods for modulating expression of members of the human Rho gene family, which encode low molecular weight GTPases that act as molecular switches in signal transduction. In preferred embodiments, Rho family members include RhoA, RhoB, RhoC, RhoG, Rac1 and cdc42. This invention is also directed to methods for inhibiting hyperproliferation of cells; these methods can be used diagnostically or therapeutically. Furthermore, this invention is directed to treatment of conditions associated with expression of the human Rho family members, particularly in hyperproliferative disorders.
    Type: Application
    Filed: June 21, 2002
    Publication date: October 23, 2003
    Inventors: M. Luisa Roberts, Lex M. Cowsert
  • Publication number: 20030175793
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of NF-kappa-B p65 subunit. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding NF-kappa-B p65 subunit. Methods of using these compounds for modulation of NF-kappa-B p65 subunit expression and for treatment of diseases associated with expression of NF-kappa-B p65 subunit are provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: September 18, 2003
    Inventors: C. Frank Bennett, Brett P. Monia, Lex M. Cowsert
  • Publication number: 20030166592
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of liver glycogen phosphorylase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding liver glycogen phosphorylase. Methods of using these compounds for modulation of liver glycogen phosphorylase expression and for treatment of diseases associated with expression of liver glycogen phosphorylase are provided.
    Type: Application
    Filed: April 1, 2002
    Publication date: September 4, 2003
    Inventors: Brett P. Monia, Lex M. Cowsert
  • Patent number: 6613567
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Her-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-2. Methods of using these compounds for modulation of Her-2 expression and for treatment of diseases associated with expression of Her-2 are provided.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: September 2, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: C. Frank Bennett, Lex M. Cowsert
  • Publication number: 20030148974
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Akt-3. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding Akt-3. Methods of using these compounds for modulations of Akt-3 expression and for treatment of diseases associated with expression of Akt-3 are provided.
    Type: Application
    Filed: June 21, 2002
    Publication date: August 7, 2003
    Inventors: Brett P. Monia, Lex M. Cowsert, Richard A. Roth
  • Publication number: 20030147863
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
    Type: Application
    Filed: December 17, 2001
    Publication date: August 7, 2003
    Applicant: Isis Pharmaceuticals Inc.
    Inventors: Lex M. Cowsert, Susan M. Freier
  • Patent number: 6602857
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: August 5, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Lex M. Cowsert, Jacqueline Wyatt, Brett P. Monia, Madeline M. Butler, Robert McKay
  • Publication number: 20030144241
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Smad6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad6. Methods of using these compounds for modulation of Smad6 expression and for treatment of diseases associated with expression of Smad6 are provided.
    Type: Application
    Filed: December 20, 2002
    Publication date: July 31, 2003
    Inventors: Brett P. Monia, Lex M. Cowsert
  • Publication number: 20030113739
    Abstract: Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.
    Type: Application
    Filed: April 4, 2002
    Publication date: June 19, 2003
    Inventors: Lex M. Cowsert, Brenda F. Baker, John McNeil, Susan M. Freier, Henri M. Sasmor, Douglas G. Brooks, Cara Ohashi, Jacqueline R. Wyatt, Alexander H. Borchers, Timothy A. Vickers
  • Publication number: 20030108883
    Abstract: The present invention relates to methods for identifying compounds that inhibit PTP1B mRNA and protein expression in insulin resistant non-human mammals.
    Type: Application
    Filed: February 12, 2002
    Publication date: June 12, 2003
    Inventors: Cristina M. Rondinone, James M. Trevillyan, Bradley A. Zinker, Jeffrey F. Waring, Mike Jirousek, Madeline M. Butler, Lex M. Cowsert, Brett P. Monia, Jacqueline Wyatt
  • Publication number: 20030105044
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.
    Type: Application
    Filed: October 17, 2001
    Publication date: June 5, 2003
    Applicant: Isis Pharmaceuticals Inc.
    Inventors: Brenda F. Baker, Lex M. Cowsert
  • Publication number: 20030105041
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of SHH. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHH. Methods of using these compounds for modulation of SHH expression and for treatment of diseases associated with expression of SHH are provided.
    Type: Application
    Filed: November 16, 2001
    Publication date: June 5, 2003
    Inventors: C. Frank Bennett, Lex M. Cowsert
  • Publication number: 20030105038
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of CREB. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CREB. Methods of using these compounds for modulation of CREB expression and for treatment of diseases associated with expression of CREB are provided.
    Type: Application
    Filed: October 10, 2001
    Publication date: June 5, 2003
    Applicant: Isis Pharmaceuticals Inc.
    Inventors: Brett P. Monia, Lex M. Cowsert
  • Publication number: 20030100531
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Interleukin-15. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin-15. Methods of using these compounds for modulation of Interleukin-15 expression and for treatment of diseases associated with expression of Interleukin-15 are provided.
    Type: Application
    Filed: November 19, 2002
    Publication date: May 29, 2003
    Inventors: C. Frank Bennett, Lex M. Cowsert
  • Patent number: 6566133
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Dual specific phosphatase 9. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Dual specific phosphatase 9. Methods of using these compounds for modulation of Dual specific phosphatase 9 expression and for treatment of diseases associated with expression of Dual specific phosphatase 9 are provided.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: May 20, 2003
    Assignee: Isis Pharmaceuticals, Inc.
    Inventor: Lex M. Cowsert