Abstract: Systems and methods for an online donation marketplace are provided. An oiler of a non-cash item from a donor to be sold on an online open market is received. The offer includes a pricing structure and a selected charity. The item can be any of a service, a good, or an experience. The offer is displayed to potential buyers, and when buyer requests to make a purchase, the transaction is facilitated and the donated payment is provided to the selected charity. The buyer and donor receive recognition for their charitable activity. Sometimes the donor is a merchant that offers a deal in exchange for a required donation. In other embodiments, a seeker requests an item to be donated by a donor. The seeker can be a buyer, or may be simply a beneficiary of the transaction.

Abstract: The invention is generally directed to compositions and methods for affecting signal transduction using the casein kinase I (CKI) gene or gene product. The invention is more specifically directed to affecting the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose cancer, particularly breast and colon cancer. CKI&egr; is the preferred species. The field of the invention is compositions and methods for modulating signal transduction using the (CKI) gene or gene products and variants thereof. The invention is more specifically directed to modulating the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose disorders mediated by the Wnt signal pathway, especially hyperproliferative disorders, particularly breast and colon cancer.