Patents by Inventor Lihua Chen

Lihua Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200253868
    Abstract: A cell autophagy inhibitor using a rubiaceae-type cyclopeptide as the active ingredient, and is particularly used for inhibiting KRAS mutation, especially protective autophagy of KRAS dependent tumor cells, and promoting tumor cell apoptosis; the inhibitor is preferably a nano-micelle injection, which can be used to the preparation of a medicament for treating and preventing KRAS-related cancers including colon cancer, rectal cancer, lung cancer and pancreatic cancer. The cell autophagy inhibitor of the present invention can effectively inhibit the protective autophagy of tumor cells, and its active ingredient rubiaceae-type cyclopeptides have a wide range of sources, mature extraction processes, diversified dosage forms and administration methods, and can be used to the treatment and prevention of KRAS-related cancers and have broad clinical application prospects.
    Type: Application
    Filed: January 22, 2018
    Publication date: August 13, 2020
    Inventors: Ninghua TAN, Lijuan CHEN, Lihua SONG, Jianhong YANG, Zhe WANG
  • Patent number: 10737575
    Abstract: A computer includes a processor; and a memory. The memory stores instructions executable by the processor to determine, based on a measurement performed in a vehicle, that a parameter of a power device is outside of a predetermined range; and actuate components in the vehicle to heat the power device.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: August 11, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Petros Taskas, Lihua Chen, Shuitao Yang, Fan Xu, Mohammed Khorshed Alam, Baoming Ge
  • Publication number: 20200252020
    Abstract: A vehicle includes an inverter having first and second half bridges configured to provide multiphase voltage to an electric machine. The vehicle further includes a controller configured to activate a switch of the first half bridge and pulse width modulate a switch of the second half bridge to conduct resonant output on a rail of the inverter to the electric machine such that the multiphase voltage is created for at least a sixth of a cycle of the electric machine. Thee activation is responsive to a torque command.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 6, 2020
    Inventors: Baoming Ge, Lihua Chen
  • Publication number: 20200223314
    Abstract: A controller of a vehicle power system closes a pre-charge contactor and one of a pair of main contactors to electrically connect a battery and inverter such that current flows through a pre-charge resistor. The controller also opens the pair to electrically disconnect the battery and inverter, and closes a switch configured to complete a circuit such that charge acquired by a capacitor of the inverter is dissipated via the pre-charge resistor.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 16, 2020
    Inventors: Boris Curuvija, Lihua Chen, Baoming Ge, Fan Xu
  • Patent number: 10715042
    Abstract: A variable voltage converter transfers charge between a battery and a DC link. A first inductor couples a positive battery node and a first node. A first transistor selectably couples the first node to a negative battery node. A first capacitor has a negative terminal coupled to the negative battery node. A second inductor couples a positive terminal of the first capacitor to a second node. A second capacitor has a positive terminal coupled to the first node. A second transistor selectably couples the second node to a negative terminal of the second capacitor. When the transistors are non-conducting, the second inductor charges the DC link and the first inductor charges the first and second capacitors. When the transistors are conducting, the inductors are energized in parallel by the battery and the first and second capacitors. High voltage gain is obtained at relatively low values for the PWM duty cycle.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: July 14, 2020
    Assignee: FORD GLOBAL TECHNOLOGIES, LLC
    Inventors: Baoming Ge, Lihua Chen
  • Patent number: 10707771
    Abstract: A traction inverter system includes a capacitor module, a power module, a cold plate between and in contact with the modules, and an end plate defining an inlet and outlet. The modules and plates define a bore spanning the modules and plates, and a passageway in fluid communication with the inlet and outlet. The traction inverter system also includes a mechanical fastener occupying the bore, spanning the modules and plates, and clamping the modules and plates together.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: July 7, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Lihua Chen, Fan Wang, Fan Xu, Boris Curuvija, Baoming Ge, Shahram Zarei
  • Patent number: 10700681
    Abstract: Power electronics circuitry includes a pair of parallel switching elements. Each of the switching elements includes two power terminals, two control terminals, and an additional terminal. Corresponding ones of the two power terminals from each of the pair are connected via respective first and second power paths. Corresponding ones of the two control terminals from each of the pair are connected via respective first and second control paths. The additional terminals are connected via an additional path. The circuitry also includes a gate driver tapping the first and second control paths, and a magnet surrounding the additional terminals to couple inductance of the additional path.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 30, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Fan Xu, Lihua Chen
  • Publication number: 20200141069
    Abstract: The present invention provides a pavement deicing or snow-melting system, comprising a water-permeable pavement, a drainage device and a heating device, wherein the water-permeable pavement comprises, successively from the top down, a water-permeable asphalt concrete coating, a porous cement stabilized macadam layer, a reflecting layer, a waterproof layer, a semi-rigid base and a semi-rigid cushion; the drainage device comprises a drainage ditch and a sheet cover; a water inlet is formed on the drainage ditch; a lower edge of the drainage ditch is not lower than the waterproof layer; curbs are arranged on edges of the water-permeable asphalt concrete coating and the porous cement stabilized macadam layer; and, the heating device is arranged between the water-permeable asphalt concrete coating and the porous cement stabilized macadam layer.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Inventors: Henglin XIAO, Ming HAN, Zhi CHEN, Qiang MA, Lihua LI, Zhiyong YANG, Mi TIAN, Hefu PU, Shilin WAN
  • Patent number: 10632396
    Abstract: The present disclosure discloses a microwave flash evaporation process and apparatus and uses thereof. A microwave flash evaporation process, wherein the process makes integration of those technologies for liquid spraying, liquid droplet flash evaporation, microwave enhancement, vacuum steam discharge, and simulation and optimization of multi-mode resonant cavity, wherein through the coupling effect of the microwave, by means of one stage microwave flash evaporation, the effect normally achieved by multi-effect evaporation and flash evaporation is obtained and a liquid droplet micro-system with microwave energy transfer in situ is formed so as to prevent a circulation pump and a steam heat exchange system from being corroded under high temperature and high pressure, and prevent scaling on a heat exchanger, and improve evaporation efficiency.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 28, 2020
    Assignee: KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Shaohua Ju, Jinhui Peng, Zhanyong Guo, Hua Chen, Jun Sun, Shenghui Guo, Chao Liu, Lei Xu, Linqing Dai, Lihua Zhang, Shihong Tian
  • Publication number: 20200122582
    Abstract: A shared resistor performs precharging and discharging functions of capacitors in an electric vehicle drive system. In a precharge state, the shared resistor is connected between the capacitors and a DC source via a precharge relay. In a discharge state, the resistor is connected across the capacitors via a discharge transistor. Otherwise, the resistor is disconnected. A bypass switch is connected between the resistor and an input capacitor. The bypass switch is rendered conductive during the precharge state and during the discharge state. The discharge transistor is activated only during the discharge state. As a result, the invention uses less components by virtue of eliminating separate resistance elements for pre-charging and discharging and by eliminating discharge switches dedicated to separate resistances. The circuit integration and the placement of components outside the inverter module improves overall system cost and packaging size.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 23, 2020
    Inventors: Boris Curuvija, Fan Xu, Lihua Chen, Baoming Ge
  • Publication number: 20200115379
    Abstract: Provided are certain Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 17, 2018
    Publication date: April 16, 2020
    Inventors: Hongbin LIU, Yue RONG, Huajie ZHANG, Zhifang CHEN, Rui TAN, Chengxi HE, Zhifu LI, Zuwen ZHOU, Haohan TAN, Kai RAN, Xianlong WANG, Zongyao ZOU, Lihua JIANG, Yanxin LIU, Xingdong ZHAO, Weibo WANG, Jiemin FU
  • Patent number: 10622712
    Abstract: The invention provides an electrical device, comprising a transformer (22) with a ferrite core (24) and an RF antenna (14). The antenna (14) is electrically isolated from said transformer (22), and a geometric dimension of the antenna (14) has a maximum dimension along or around a surface of the RF antenna (i.e. within the plane of the antenna or around a curved surface defining the antenna), and the RF antenna (14) is spatially spaced from a nearest part of the ferrite core (24) by less than the maximum dimension. This design makes use of the ferrite core of a transformer to provide isolation of the antenna from other parts of the device. This assists in reducing the impact of those parts of the device on the performance of the antenna, in particular the reception range.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: April 14, 2020
    Assignee: SIGNIFY HOLDING B.V.
    Inventors: Peiliang Dong, You Li, Lihua Lin, Zhi Chen
  • Patent number: 10618423
    Abstract: A powertrain for a vehicle includes a Y-wound generator, a Y-wound motor, a generator inverter, a motor inverter, and a traction battery. The Y-wound generator and Y-wound motor are coupled via each respective neutral terminal. The generator inverter is coupled between the Y-wound generator and a generator bus and the motor inverter is coupled between the Y-wound motor and a motor bus. The traction battery has a first terminal coupled to each neutral terminal and a second terminal coupled to bus terminals of the generator and motor bus.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: April 14, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Baoming Ge, Lihua Chen, Yan Zhou, Shuitao Yang, Fan Xu
  • Patent number: 10618428
    Abstract: A vehicle includes an inverter connected to an energy store having a variable output voltage and including a first pair of battery partitions. The vehicle includes a controller configured to operate a first set of switches to arrange electrical connections between the first pair such that the variable output voltage is greater than battery voltage of a one of the battery partitions. The operation of switches is responsive to a parameter indicative of speed of an electric machine electrically coupled to the inverter exceeding a first predetermined threshold.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: April 14, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Baoming Ge, Lihua Chen, Shuitao Yang, Yan Zhou, Fan Xu, Khorshed Khorshed Alam
  • Patent number: 10611246
    Abstract: A vehicle powertrain includes a monolithically integrated load switch, mirror switch, and temperature array, and a gate driver. The gate driver includes a first comparator configured to filter a current level of the mirror switch, and a second comparator configured to provide a reference to the first comparator based on temperature array output such that a gate discharge rate of the switch, enabled by the first comparator, varies proportionally with a temperature adjusted filtered current level.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: April 7, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Yan Zhou, Lihua Chen, Shuitao Yang, Fan Xu, Mohammed Khorshed Alam, Baoming Ge
  • Publication number: 20200094685
    Abstract: A vehicle electric drive includes a controller programmed to operate a power converter to boost voltage from a battery for a DC bus and to limit voltage output from the power converter to a predefined maximum voltage value that varies with temperature of coolant used to cool the power converter.
    Type: Application
    Filed: September 24, 2018
    Publication date: March 26, 2020
    Inventors: Lihua Chen, Boris Curuvija, Baoming Ge
  • Patent number: 10576828
    Abstract: A variable voltage converter for an electric drive system has upper and lower switching devices in series between positive and negative buses. An inductance couples a junction between the switching devices to a DC battery. A controller is configured to drive the switches according to PWM gate signals based on an expected boost ratio of the converter. The PWM gate signals have a nominal dead-time insertion for both the upper and lower switching devices when the expected boost ratio is greater than a predetermined boost ratio. In order to extend a range of achievable boost ratios during regeneration operation, the PWM gate signals are without dead-time insertion for the upper switching device and the lower switching device remains continuously off when the expected boost ratio is less than the predetermined boost ratio.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: March 3, 2020
    Assignee: FORD GLOBAL TECHNOLOGIES, LLC
    Inventors: Jogendra S. Thongam, Shuitao Yang, Mohammed Khorshed Alam, Lihua Chen, Fan Xu, Yan Zhou
  • Patent number: 10581361
    Abstract: A vehicle may include an electric machine including windings having a nonzero phase offset. The vehicle may further include first and second inverters configured to drive the electric machine as a result of toggling of switches. The switches may be toggled according to respective pulse width modulation (PWM) signals. One or more gate drivers may be configured to generate the PWM signals. The PWM signals may be based on fundamental waveforms having a phase shift that is based on the nonzero phase offset of the electric machine.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: March 3, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Lihua Chen, Baoming Ge, Shuitao Yang, Shahram Zarei
  • Patent number: 10581363
    Abstract: A powertrain for a vehicle includes a Y-wound generator and Y-wound motor coupled via respective neutral terminals, a generator inverter coupled between the Y-wound generator and a generator bus, and a motor inverter coupled between the Y-wound motor and a motor bus. The powertrain further includes a traction battery having first and second terminals each selectively coupled to the neutral terminals. The second terminal is further coupled to bus terminals of the generator and motor bus.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: March 3, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Baoming Ge, Lihua Chen
  • Patent number: 10574223
    Abstract: Power electronics circuitry has a pair of parallel power semiconductors each including a gate and a current sensor, a first differential mode choke defining a portion of a gate path connecting the gates, a second differential mode choke defining a portion of a sensor path connecting the current sensors, and a gate driver tapping the gate and current sensor paths.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: February 25, 2020
    Assignee: Ford Global Technologies, LLC
    Inventors: Fan Xu, Lihua Chen