Patents by Inventor Lili GUO

Lili GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220289661
    Abstract: A carbonylation-dehydration dual-functional catalyst precursor, a preparation method thereof, a carbonylation-dehydration dual-functional catalyst and use thereof are provided. The carbonylation-dehydration dual-functional catalyst precursor includes a modified silica-aluminum molecular sieve having an 8-member ring channel structure; a modified metal oxie loaded on the modified silica-aluminum molecular sieve having an 8-member ring channel structure by coupling, the coupling being performed using a silane coupling agent, wherein a modified component in the modified silica-aluminum molecular sieve having an 8-member ring channel structure includes at least one selected from the group consisting of copper oxide, zing oxide and iron oxide, and has a loading amount of 0.
    Type: Application
    Filed: March 8, 2022
    Publication date: September 15, 2022
    Inventors: Nuowei Zhang, Xinliang Lin, Binghui Chen, Lili Guo, Fan Cai, Songshou Ye, Jianrong Xie, Jinbao Zheng
  • Publication number: 20220288168
    Abstract: The present disclosure relates to the field of medicine. More particularly, the disclosure is in the field of treatment of diabetes, obesity and/or chronic weight management, dyslipidemia and/or NASH. The disclosure relates to compounds that agonize the amylin receptor and can lower food intake, body weight, glucose and/or triglycerides, so can be used to treat diabetes, obesity, and/or dyslipidemia. The present disclosure also includes pharmaceutical compositions containing such compounds and therapeutic uses of such compounds and compositions.
    Type: Application
    Filed: March 2, 2022
    Publication date: September 15, 2022
    Inventors: Milata Mary ABRAHAM, Daniel Anthony BRIERE, Lili GUO, Samantha Grace Lyons KEYSER, John LEE, Hongchang QU
  • Patent number: 11421199
    Abstract: Provided is a recombinant yeast expressing germacrene A synthetase or a fusion protein thereof, wherein the fusion protein is germacrene A synthetase and farnesyl pyrophosphate synthase. The recombinant yeast improves the yield of germacrene A, and is suitable for the industrialized production of ?-elemene and/or germacrene A.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: August 23, 2022
    Assignees: Tianjin institute of Industrial Biotechnology, Chinese Academy of Sciences, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
    Inventors: Xueli Zhang, Luqi Huang, Zhubo Dai, Dong Wang, Lili Zhang, Juan Guo, Yi Liu
  • Publication number: 20220259306
    Abstract: Provided are an antibody targeting NKG2A, a preparation method therefor and use thereof. Specifically, provided is a new mouse or humanized monoclonal antibody targeting NKG2A, and a method for preparing the monoclonal antibody. The monoclonal antibody can bind to an NKG2A antigen with high specificity, and has high affinity and significant activities such as anti-tumor activity.
    Type: Application
    Filed: November 6, 2019
    Publication date: August 18, 2022
    Inventors: Qing DUAN, Lile LIU, Dazhi YANG, Jing GAO, Lili HU, Ruirui SUI, Dongxu WANG, Ye HAN, Rongrong XIE, Yan LU, Xiaohui SHAO, Jie ZHANG, Wenming ZHOU, Cuicui GUO, Guozhen TONG, Lina WANG, Chaohui DAI, Mengying WANG
  • Patent number: 11373337
    Abstract: The present disclosure is related to an image processing method of virtual reality. The image processing method may include obtaining position information of a gaze point; performing a compression process on an original image to obtain a compressed image based on the position information of the gaze point; performing a compression process on a distorted image of the original image in an lens to obtain a compressed distorted image based on the position information of the gaze point; and performing an anti-distortion process on the compressed image to obtain an anti-distortion image based on a relationship between the compressed image and the compressed distorted image. The position information of the gaze point may be position information of a gaze point of a user's eye on an original image.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: June 28, 2022
    Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Jinghua Miao, Hao Zhang, Lili Chen, Yukun Sun, Yali Liu, Xi Li, Bin Zhao, Xuefeng Wang, Lixin Wang, Jianwen Suo, Wenyu Li, Ziqiang Guo, Ruifeng Qin, Guixin Yan, Feng Pan
  • Publication number: 20220193214
    Abstract: The present disclosure belongs to the technical field of veterinary biological products, and specifically relates to a triple vaccine for diseases caused by Salmonella typhimurium, Riemerella anatipestifer and Escherichia coli. In the triple vaccine, antigens are an inactivated Salmonella typhimurium E01 strain, an inactivated Riemerella anatipestifer R01 strain and an inactivated Escherichia coli E01 strain. The three strains used in the vaccine have high virulence, disable immunogenicity and disable cross-protection. The prepared vaccine has a desirable safety, causing no local or systemic adverse reactions. In a shelf life test, all indicators of the vaccine are stable and effective after a data analysis of traits, a safety test and an efficacy test; in addition, efficacy test results prove that the inactivated triple vaccine can produce desirable antibodies and relatively desirable attacking protection.
    Type: Application
    Filed: November 22, 2021
    Publication date: June 23, 2022
    Applicant: Qingdao Bolin Biological Technology Co., Ltd.
    Inventors: Yongda Zhao, Lili Guo, Lihua Ma
  • Publication number: 20220127315
    Abstract: The present invention relates to compounds having activity at the human glucose-dependent insulinotropic polypeptide (GIP) receptor. The present invention also relates to compounds having an extended duration of action at the GIP receptor. Such compounds may be useful in the treatment of diabetes, including type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.
    Type: Application
    Filed: January 11, 2022
    Publication date: April 28, 2022
    Inventors: Jorge ALSINA-FERNANDEZ, Andrea Renee GEISER, Lili GUO, Samantha Grace Lyons KEYSER, John LEE, Hongchang QU, William Christopher ROELL
  • Patent number: 11254721
    Abstract: The present invention relates to compounds having activity at the human glucose-dependent insulinotropic polypeptide (GIP) receptor. The present invention also relates to compounds having an extended duration of action at the GIP receptor. Such compounds may be useful in the treatment of diabetes, including type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: February 22, 2022
    Assignee: Eli Lilly and Company
    Inventors: Jorge Alsina-Fernandez, Andrea Renee Geiser, Lili Guo, Samantha Grace Lyons Keyser, John Lee, Hongchang Qu, William Christopher Roell
  • Publication number: 20210221865
    Abstract: Incretin analogs are provided that have activity at each of the GIP, GLP-1 and glucagon receptors. The incretin analogs have structural features resulting in balanced activity and extended duration of action at each of these receptors. Methods also are provided for treating diseases such as diabetes mellitus, dyslipidemia, fatty liver disease, metabolic syndrome, non-alcoholic steato-hepatitis and obesity.
    Type: Application
    Filed: December 14, 2018
    Publication date: July 22, 2021
    Inventors: Jorge Alsina-Fernandez, Tamer Coskun, Lili Guo, Hongchang Qu
  • Publication number: 20210223259
    Abstract: A method of enhancing a mass spectral signal is disclosed. The method can include contacting a sample to a separation column under conditions that permit sample components to bind to the substrate; applying a first mobile gradient to the separation column, wherein the first mobile phase gradient comprises trifluoroacetic acid (TFA) and a small molecule additive (e.g., an amino acid) or formic acid (FA) and a small molecule additive (e.g., an amino acid); applying a second mobile gradient to the separation column, wherein the second mobile phase gradient comprises TFA in acetonitrile (ACN) and a small molecule additive (e.g., an amino acid) or formic acid (FA) in ACN and a small molecule additive (e.g., an amino acid); and performing mass spectrometric analysis on eluted sample components.
    Type: Application
    Filed: January 7, 2021
    Publication date: July 22, 2021
    Inventors: Yuan Mao, Andrew Kleinberg, Yunlong Zhao, Lili Guo
  • Publication number: 20210032299
    Abstract: The present invention relates to compounds having activity at the human glucose-dependent insulinotropic polypeptide (GIP) receptor. The present invention also relates to compounds having an extended duration of action at the GIP receptor. Such compounds may be useful in the treatment of diabetes, including type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.
    Type: Application
    Filed: July 29, 2020
    Publication date: February 4, 2021
    Inventors: Jorge ALSINA-FERNANDEZ, Andrea Renee GEISER, Lili GUO, Samantha Grace Lyons KEYSER, John LEE, Hongchang QU, William Christopher ROELL
  • Patent number: 10894817
    Abstract: The present invention provides a compound or a pharmaceutically acceptable salt of the Formula: X1IVX2SLDVPIGLLQILX3EQEKQEKEKQQAK*TNAX4ILAQV-NH2 wherein the X1 denotes that the I residue is modified by either acetylation or methylation at the N-terminus; wherein X2 is L or T; wherein X3 is L or I; wherein X4 is Q or E; and wherein a modified K residue (“K*”) at position 29 is modified through conjugation to the epsilon-amino group of the K-side chain with a group of the formula —X5—X6, wherein X5 is selected from the group consisting of one to four amino acids; one to four ([2-(2-Amino-ethoxy)-ethoxy]-acetyl) moieties; and combinations of one to four amino acids and one to four ([2-(2-Amino-ethoxy)-ethoxy]-acetyl) moieties; and X6 is a C14-C24 fatty acid. In some embodiments, the group of the formula —X5—X6 is ([2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(?E)2-CO—(CH2)x—CO2H where x is 16 or 18.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: January 19, 2021
    Assignee: Eli Lilly and Company
    Inventors: Jorge Alsina-Fernandez, Lili Guo, John Lee
  • Publication number: 20200331980
    Abstract: Incretin analogs are provided that have activity at each of the GIP, GLP-1 and glucagon receptors. The incretin analogs have structural features resulting in balanced activity and extended duration of action at each of these receptors. Methods also are provided for treating diseases such as diabetes mellitus, dyslipidemia, fatty liver disease, metabolic syndrome, non-alcoholic steatohepatitis and obesity.
    Type: Application
    Filed: December 14, 2018
    Publication date: October 22, 2020
    Inventors: Jorge Alsina-Fernandez, Tamer Coskun, Lili Guo, Hongchang Qu
  • Patent number: 10788408
    Abstract: A method for determining the diffusion radius of in-situ injection and remediation of contaminated soil and groundwater. According to the triangle method, the hole spacing is perpendicular to the groundwater flow direction, the row spacing is along the groundwater flow direction, and the flow diffusion in the groundwater during the effective time of the remediation agent reaction is considered. Under high pressure rotary injection, the remediation agent and a certain proportion of bromide ions are simultaneously injected into the aquifer as a tracer. The diffusion of the agent is determined by observing the phenomenon of slurry-returning and slurry-channeling of adjacent injection points. After the completion of the injection, the groundwater is quickly sampled in fixed depth, the tracer concentration is quickly detected on site, and the concentration of bromide ions in the groundwater is compared with the background value. Comprehensive determination determines the optimal diffusion radius.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: September 29, 2020
    Assignee: BCEG Environmental Remediation Co., Ltd
    Inventors: Yuewei Yang, Shupeng Li, Yue Zhang, Xiaobin Zhang, Lili Guo, Shuangchao Cui, Xiaowei Song, Fan Chen, Pengcheng Yin, Peng Liu, Yan Liu, Qiang Niu
  • Patent number: 10787865
    Abstract: An in-situ injection of soil and groundwater—high pressure rotary jet grouting in-situ remediation system and method. The system has an agent dispensing station, high pressure grouting pump, air compressor, rotary jet grouting drilling machine, second double-pipe water flow joint, automatic lifting mechanism for grouting drill pipe of rotary jet grouting drilling machine, high pressure jet drill pipe, inner tube for high pressure jet triple drill pipe, outer tube for high pressure jet triple drill pipe, agent jet nozzle, an air jet nozzle, cemented carbide block and a drill bit. Parameters are arranged according to the triangle method to ensure that the remediation area is covered within the diffusion radius of the agent. After positioning the GPS measuring point, a guided-boring rig is positioned at the center of the injection point.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: September 29, 2020
    Assignee: BCEG Environmental Remediation Co., Ltd
    Inventors: Shupeng Li, Yuewei Yang, Lili Guo, Peng Liu, Yue Zhang, Xiaowei Song, Fan Chen, Pengcheng Yin, Fuwang Wang, Yan Liu, Qiang Niu, Fanyang Bu
  • Patent number: 10682680
    Abstract: An in-situ chemical oxidation high pressure injection optimization remediation method for soil and groundwater. A field test determines the diffusion radius of the injection agent in a typical formation, the maximum single-hole grouting amount per linear meter and the injectability parameter. Density-increased supplementary investigation, soil and groundwater data analysis, is divided by spatial distribution into four concentration main partitions, eight concentration sub-partitions. By optimizing the single-hole grouting amount per linear meter, the preparation concentration of the oxidant, and the parameters of the formulation of each partition, the optimization of the dosing ratio of remediation agent of each partition is achieved. The specific construction performance is to adjust the lifting speed of the high pressure injection drill pipe during the injection process for finally achieve the purpose of reducing the dosing ratio parameters of the agent in the remediation plot.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: June 16, 2020
    Assignee: BCEG ENVIRONMENTAL REMEDIATION CO., LTD.
    Inventors: Yuewei Yang, Shupeng Li, Yue Zhang, Fuwang Wang, Lili Guo, Xiaowei Song, Fan Chen, Pengcheng Yin, Shuangchao Cui, Yan Liu, Qiang Niu
  • Publication number: 20190224729
    Abstract: An in-situ chemical oxidation high pressure injection optimization remediation method for soil and groundwater. A field test determines the diffusion radius of the injection agent in a typical formation, the maximum single-hole grouting amount per linear meter and the injectability parameter. Density-increased supplementary investigation, soil and groundwater data analysis, is divided by spatial distribution into four concentration main partitions, eight concentration sub-partitions. By optimizing the single-hole grouting amount per linear meter, the preparation concentration of the oxidant, and the parameters of the formulation of each partition, the optimization of the dosing ratio of remediation agent of each partition is achieved. The specific construction performance is to adjust the lifting speed of the high pressure injection drill pipe during the injection process for finally achieve the purpose of reducing the dosing ratio parameters of the agent in the remediation plot.
    Type: Application
    Filed: May 16, 2017
    Publication date: July 25, 2019
    Inventors: Yuewei YANG, Shupeng LI, Yue ZHANG, Fuwang WANG, Lili GUO, Xiaowei SONG, Fan CHEN, Pengcheng YIN, Shuangchao CUI, Yan LIU, Qiang NIU
  • Publication number: 20190145190
    Abstract: An in-situ injection of soil and groundwater—high pressure rotary jet grouting in-situ remediation system and method. The system has an agent dispensing station, high pressure grouting pump, air compressor, rotary jet grouting drilling machine, second double-pipe water flow joint, automatic lifting mechanism for grouting drill pipe of rotary jet grouting drilling machine, high pressure jet drill pipe, inner tube for high pressure jet triple drill pipe, outer tube for high pressure jet triple drill pipe, agent jet nozzle, an air jet nozzle, cemented carbide block and a drill bit. Parameters are arranged according to the triangle method to ensure that the remediation area is covered within the diffusion radius of the agent. After positioning the GPS measuring point, a guided-boring rig is positioned at the center of the injection point.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 16, 2019
    Inventors: Shupeng LI, Yuewei YANG, Lili GUO, Peng LIU, Yue ZHANG, Xiaowei SONG, Fan CHEN, Pengcheng YIN, Fuwang WANG, Yan LIU, Qiang NIU, Fanyang BU
  • Publication number: 20190120741
    Abstract: A method for determining the diffusion radius of in-situ injection and remediation of contaminated soil and groundwater. According to the triangle method, the hole spacing is perpendicular to the groundwater flow direction, the row spacing is along the groundwater flow direction, and the flow diffusion in the groundwater during the effective time of the remediation agent reaction is considered. Under high pressure rotary injection, the remediation agent and a certain proportion of bromide ions are simultaneously injected into the aquifer as a tracer. The diffusion of the agent is determined by observing the phenomenon of slurry-returning and slurry-channeling of adjacent injection points. After the completion of the injection, the groundwater is quickly sampled in fixed depth, the tracer concentration is quickly detected on site, and the concentration of bromide ions in the groundwater is compared with the background value. Comprehensive determination determines the optimal diffusion radius.
    Type: Application
    Filed: May 16, 2017
    Publication date: April 25, 2019
    Inventors: Yuewei YANG, Shupeng LI, Yue ZHANG, Xiaobin ZHANG, Lili GUO, Shuangchao CUI, Xiaowei SONG, Fan CHEN, Pengcheng YIN, Peng LIU, Yan LIU, Qiang NIU
  • Publication number: 20180163202
    Abstract: The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or protein aggregates. In certain instances, the compositions and methods relate to modulators of one or more TRIM proteins or one or more STUbLs.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 14, 2018
    Inventors: Xialou Yang, Lili Guo