Patents by Inventor Liliana Maria Tejidor

Liliana Maria Tejidor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reconstitution of purified membrane proteins into preformed liposomes
    Patent number: 6706861
    Abstract: The present application relates to a method of making liposomes having membrane proteins incorporated therein, the method comprising: providing the membrane protein in solution; providing a solution of preformed liposomes; and incubating the mixture. Prior to the step of providing a solution of preformed liposomes, the liposomes are formed by combining a mixture of phospholipids with a solution of at least one type of unsaturated fatty acid. The methods of the present invention further relate to the method of making a reagent comprising tissue factor reconstituted into preformed liposomes. The method of the present invention for making a tissue factor reagent comprises: providing tissue factor in solution; providing a solution of preformed liposomes comprising a mixture of phospholipids and at least one type of unsaturated fatty acid; and incubating the mixture.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: March 16, 2004
    Assignee: Dade Behring, Inc.
    Inventors: Pratap Singh, Jianfang Wang, Liliana Maria Tejidor
  • Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
    Patent number: 6596543
    Abstract: The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native thromboplastin or purified or recombinant tissue factor and phospholipids from a natural or synthetic source. The present invention relates to methods to make a diagnostic reagent that includes a membrane-bound protein incorporated into a liposome and having additional empty liposomes (liposomes without membrane-bound protein incorporated therein) added to the solution.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: July 22, 2003
    Assignee: Dade Behring Inc.
    Inventors: Jianfang Wang, Kevin Bruce Johnson, Liliana Maria Tejidor, Hema Doobay
  • Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
    Publication number: 20020182225
    Abstract: The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native thromboplastin or purified or recombinant tissue factor and phospholipids from a natural or synthetic source. The present invention relates to methods to make a diagnostic reagent that includes a membrane-bound protein incorporated into a liposome and having additional empty liposomes (liposomes without membrane-bound protein incorporated therein) added to the solution.
    Type: Application
    Filed: March 22, 2001
    Publication date: December 5, 2002
    Inventors: Jianfang Wang, Kevin Bruce Johnson, Liliana Maria Tejidor, Hema Doobay
  • Reconstitution of purified membrane proteins into preformed liposomes
    Publication number: 20020012699
    Abstract: The present application relates to a method of making liposomes having membrane proteins incorporated therein, the method comprising: providing the membrane protein in solution; providing a solution of preformed liposomes; and incubating the mixture. Prior to the step of providing a solution of preformed liposomes, the liposomes are formed by combining a mixture of phospholipids with a solution of at least one type of unsaturated fatty acid. The methods of the present invention further relate to the method of making a reagent comprising tissue factor reconstituted into preformed liposomes. The method of the present invention for making a tissue factor reagent comprises: providing tissue factor in solution; providing a solution of preformed liposomes comprising a mixture of phospholipids and at least one type of unsaturated fatty acid; and incubating the mixture.
    Type: Application
    Filed: March 22, 2001
    Publication date: January 31, 2002
    Inventors: Pratap Singh, Jianfang Wang, Liliana Maria Tejidor