Patents by Inventor Lin-nar L. Teng

Lin-nar L. Teng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4820811
    Abstract: A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R.sup.1 and R.sup.2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms; andR, R' and R" are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms, ##STR2## where R.sup.1, R.sup.2 and R" are as defined above, ##STR3## where R.sup.3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms; and R.sup.1, R.sup.2, R.sup.3 and R' having the meanings given above; and ##STR4## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: April 11, 1989
    Assignee: Research Corporation
    Inventor: Lin-nar L. Teng
  • Patent number: 4654327
    Abstract: A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R.sup.1 and R.sup.2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms; andR, R' and R" are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms, ##STR2## where R.sup.1, R.sup.2 and R" are as defined above, ##STR3## where R.sup.3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms; and R.sup.1, R.sup.2, R.sup.3 and R and R' have the meanings given above; and ##STR4## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound.
    Type: Grant
    Filed: December 3, 1985
    Date of Patent: March 31, 1987
    Assignee: Research Corp.
    Inventor: Lin-nar L. Teng
  • Patent number: 4604376
    Abstract: A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R.sup.1 and R.sup.2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms; andR, R' and R" are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms, ##STR2## where R.sup.1, R.sup.2 and R" are as defined above, ##STR3## where R.sup.3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms; and R.sup.1, R.sup.2, R.sup.3 and R and R' have the meanings given above; and ##STR4## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: August 5, 1986
    Assignee: Research Corporation
    Inventor: Lin-nar L. Teng
  • Patent number: 4582820
    Abstract: An enterally effective, biologically active peptide or protein composition, comprising a sandwich complex comprising a hydrophobic core complex of a biologically active peptide or protein with an alkyl or alkenyl sulfate having 6-24 carbon atoms and 0-3 double bonds which form an electrostatic complex with a soft quaternary ammonium ion of the formula NR.sup.1 R.sup.2 R.sup.3 R.sup.4 wherein R.sup.1 represents a C.sub.1 -C.sub.12 -alkyl group; R.sup.2 and R.sup.3 independently represent hydrogen or a C.sub.1 -C.sub.12 -alkyl group; and R.sup.4 represents hydrogen or a radical of the formula ##STR1## where R.sup.5 is hydrogen, C.sub.1 -C.sub.5 n-alkyl group and R.sup.6 is a linear alkyl or alkenyl group having 6-22 carbon atoms and 0-3 double bonds; or R.sup.1 and R.sup.2 together represent a divalent radical of the formula --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.dbd.CH--N.dbd.CH--, or --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- and R.sup.3 and R.sup.
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: April 15, 1986
    Assignee: Research Corporation
    Inventor: Lin-nar L. Teng
  • Patent number: 4510135
    Abstract: An orally administrable heparin comprising: a complex of heparin with (1) a protonated tertiary organic ammonium ion having the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a branched or unbranched alkyl group of 1 to 12 carbon atoms, which may be unsubstituted or substituted with hydroxy or alkoxy groups, or R.sup.1 and R.sup.3 together with the N atom can form a pyrrolidine, imidazole or morpholine ring; or (2) an ester-containing quaternary ammonium ion having the formula: ##STR2## wherein R.sup.4, R.sup.5 and R.sup.6 each independently represent a branched or unbranched alkyl group of 1 to 12 carbon atoms, which may be unsubstituted or substituted with hydroxy or alkoxy groups, or R.sup.4 and R.sup.6 together with the N atom can form a pyrrolidine, imidazole or morpholine ring;R.sup.7 represents an alkyl group of 4 to 16 carbon atoms; andR.sup.8 represents a hydrogen atom or a methyl group.
    Type: Grant
    Filed: April 21, 1982
    Date of Patent: April 9, 1985
    Assignee: Research Corporation
    Inventor: Lin-nar L. Teng