Patents by Inventor Linda L. Cahalan

Linda L. Cahalan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5866113
    Abstract: A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: February 2, 1999
    Assignee: Medtronic, Inc.
    Inventors: Marc Hendriks, Michel Verhoeven, Linda L. Cahalan, Patrick T. Cahalan, Benedicte Fouache
  • Patent number: 5834051
    Abstract: To minimize the incidence and consequences of device related infection that occur after prosthetics implants of neuro-muscular stimulating devices, an infection resistant intra-muscular lead has been developed and is disclosed herein. Infection incidence has been decreased by using biomaterials able to release antibacterial drugs (gentamicin) at a controlled rate for the first 3-6 weeks after implant.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: November 10, 1998
    Assignee: Medtronic, Inc.
    Inventors: Jean A. Woloszko, Marc Hendriks, Patrick T. Cahalan, Michel L. P. M. Verhoeven, Linda L. Cahalan, Antoine N. J. Camps
  • Patent number: 5811151
    Abstract: A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: September 22, 1998
    Assignee: Medtronic, Inc.
    Inventors: Marc Hendriks, Michel Verhoeven, Linda L. Cahalan, Patrick T. Cahalan, Benedicte Fouache
  • Patent number: 5782908
    Abstract: A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
    Type: Grant
    Filed: November 14, 1996
    Date of Patent: July 21, 1998
    Assignee: Medtronic, Inc.
    Inventors: Linda L. Cahalan, Patrick T. Cahalan, Michel Verhoeven, Marc Hendriks, Benedicte Fouache
  • Patent number: 5755758
    Abstract: To minimize the incidence and consequences of device related infection that occur after prosthetics implants of neuro-muscular stimulating devices, an infection resistant intramuscular lead has been developed. Infection incidence has been decreased by using biomaterials able to release antibacterial drugs (gentamicin) at a controlled rate for the first 3-6 weeks after implant.
    Type: Grant
    Filed: November 7, 1995
    Date of Patent: May 26, 1998
    Assignee: Medtronic, Inc.
    Inventors: Jean A. Woloszko, Marc Hendriks, Patrick T. Cahalan, Michel L. P. M. Verhoeven, Linda L. Cahalan, Antoine N. J. Camps
  • Patent number: 5679659
    Abstract: An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH in the range of about 4.5-8. This mixture is reacted for at least 3 hours while protected from light and is then applied to the immobilized amine groups. This is an improvement over the prior art methods which included using an excess of periodate and then stopping the reaction at a desired point by the addition of glycerol since the conversion of only a few of the natural functional groups to aldehydes better preserves the antithrombotic bioeffectiveness of the heparin molecules bound to the surface. The invention also avoids the prior art steps of drying and reconstituting the heparin by providing a reacted mixture of heparin and periodate that can be stored as a stable liquid and applied directly to the aminated surface several days later.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: October 21, 1997
    Assignee: Medtronic, Inc.
    Inventors: Michel Verhoeven, Linda L. Cahalan, Marc Hendriks, Benedicte Fouache, Patrick T. Cahalan
  • Patent number: 5672638
    Abstract: An improved coating and spacer material for a medical device having a blood or tissue-contacting surface comprising a polyalkyleneimine layer which is crosslinked with a crosslinking agent which is at least difunctional in polymerizable vinyl groups which have adjacent strong electron-withdrawing groups and a biomolecule covalently bonded to the crosslinked polyalkyleneimine layer. For example, polyethyleneimine crosslinked with divinyl sulfone could be used. The resulting crosslinked spacer layer has improved uniformity and stability without materially limiting the covalent attachment of a biomolecule such as heparin.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: September 30, 1997
    Assignee: Medtronic, Inc.
    Inventors: Michel Verhoeven, Linda L. Cahalan, Marc Hendriks, Benedicte Fouache, Patrick T. Cahalan
  • Patent number: 5607475
    Abstract: A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: March 4, 1997
    Assignee: Medtronic, Inc.
    Inventors: Linda L. Cahalan, Patrick T. Cahalan, Michel Verhoeven, Marc Hendriks, Benedicte Fouache