Patents by Inventor Linda May Rothblum Watkins

Linda May Rothblum Watkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220313785
    Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
    Type: Application
    Filed: June 21, 2022
    Publication date: October 6, 2022
    Applicants: Xalud Therapeutics, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Raymond A. Chavez, Linda May Rothblum Watkins, Robert Landry
  • Publication number: 20200093892
    Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
    Type: Application
    Filed: October 31, 2019
    Publication date: March 26, 2020
    Applicants: Xalud Therapeutics, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Raymond A. Chavez, Linda May Rothblum Watkins, Robert Landry
  • Publication number: 20140093476
    Abstract: Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
    Type: Application
    Filed: October 29, 2013
    Publication date: April 3, 2014
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: LINDA MAY ROTHBLUM WATKINS, ERIN MILLIGAN
  • Patent number: 8598133
    Abstract: Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: December 3, 2013
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Linda May Rothblum Watkins, Erin Milligan
  • Patent number: 8524678
    Abstract: Methods of delivering transgenes to target cells using plasmids comprising viral inverted terminal repeat (ITR) sequences are described. Such plasmids are capable of directing sustained transgene expression in target cells in rats provided that at least one adeno-associated virus (AAV) ITR sequence is present in the plasmid, regardless of whether that ITR is located upstream or downstream of the transgene. In a particular embodiment, plasmids comprising one or more AAV ITR sequence and an IL-10 transgene are shown to be effective in sustained reversal of pain in an animal model of neuropathic pain.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: September 3, 2013
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Linda May Rothblum Watkins, Travis Hughes, Raymond A. Chavez
  • Publication number: 20110275664
    Abstract: The present invention is directed to the use of ibudilast for treating addictions, including drug and behavioral addictions. In particular, ibudilast is used to diminish the dopamine-mediated reward associated with addictions and to treat withdrawal syndromes after discontinuance of addictive drug use or behavior. In addition, methods are provided for preventing or inhibiting relapse in human subjects having a history of methamphetamine addiction or dependence by the administration of an effective amount of ibudilast.
    Type: Application
    Filed: March 28, 2011
    Publication date: November 10, 2011
    Inventors: Kirk W. Johnson, Linda May Rothblum Watkins
  • Publication number: 20110251229
    Abstract: The invention provides 4,5-epoxymorphinan or a derivative thereof, a morphinan or a derivative thereof, or a pharmaceutical salt or a prodrug thereof. The present invention also provides compositions comprising the same, and methods for using the same. In particular, the invention relates to TLR antagonistic opioids and methods for using the same.
    Type: Application
    Filed: October 30, 2008
    Publication date: October 13, 2011
    Applicant: The Regents of the University of Colorado
    Inventors: Linda May Rothblum Watkins, Mark Rowland Hutchinson, Kenner C. Rice
  • Patent number: 7915285
    Abstract: The present invention is directed to the use of ibudilast for treating addictions, including drug and behavioral addictions. In particular, ibudilast is used to diminish the dopamine-mediated reward associated with addictions and to treat withdrawal syndromes after discontinuance of addictive drug use or behavior.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: March 29, 2011
    Assignees: The Regents of the University of Colorado, Medicinova, Inc.
    Inventors: Kirk W. Johnson, Linda May Rothblum Watkins
  • Publication number: 20100239523
    Abstract: The invention provides Toll-like receptor (TLR) modulators, compositions comprising the same, and methods for using the same.
    Type: Application
    Filed: October 30, 2008
    Publication date: September 23, 2010
    Applicant: The Regents of the University of Colorado
    Inventors: Linda May Rothblum Watkins, Mark Rowland Hutchinson
  • Patent number: 7749490
    Abstract: IL-10 sequence variants are disclosed that retain the therapeutically desirable anti-inflammatory properties of wild-type IL-10 but do not retain the hemoatopoeitic cell regulatory and cell proliferative activities. The mutant IL-10 polypeptides of the invention are used in methods of treating diseases involving inflammatory response, including neuropathic pain and other neurological disorders.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: July 6, 2010
    Assignee: The Regents of the University of Colorado
    Inventors: Jurg M. Sommer, Raymond A. Chavez, Kirk W. Johnson, Linda May Rothblum Watkins
  • Publication number: 20090208563
    Abstract: Methods of delivering transgenes to target cells using plasmids comprising viral inverted terminal repeat (ITR) sequences are described. Such plasmids are capable of directing sustained transgene expression in target cells in rats provided that at least one adeno-associated virus (AAV) ITR sequence is present in the plasmid, regardless of whether that ITR is located upstream or downstream of the transgene. In a particular embodiment, plasmids comprising one or more AAV ITR sequence and an IL-10 transgene are shown to be effective in sustained reversal of pain in an animal model of neuropathic pain.
    Type: Application
    Filed: May 26, 2006
    Publication date: August 20, 2009
    Inventors: Linda May Rothblum Watkins, Travis Hughes, Raymond A. Chavez
  • Publication number: 20090136453
    Abstract: Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 28, 2009
    Applicant: The Regents of the University of Colorado
    Inventor: Linda May Rothblum Watkins
  • Publication number: 20090035256
    Abstract: IL-10 sequence variants are disclosed that retain the therapeutically desirable anti-inflammatory properties of wild-type IL-10 but do not retain the hemoatopoeitic cell regulatory and cell proliferative activities. The mutant IL-10 polypeptides of the invention are used in methods of treating diseases involving inflammatory response, including neuropathic pain and other neurological disorders.
    Type: Application
    Filed: May 26, 2006
    Publication date: February 5, 2009
    Inventors: Jurg M. Sommer, Raymond A. Chavez, Kirk W. Johnson, Linda May Rothblum Watkins
  • Patent number: 7261882
    Abstract: Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: August 28, 2007
    Assignee: Reagents of the University of Colorado
    Inventor: Linda May Rothblum Watkins
  • Publication number: 20040258671
    Abstract: Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
    Type: Application
    Filed: December 18, 2003
    Publication date: December 23, 2004
    Inventor: Linda May Rothblum Watkins