Patents by Inventor Lindsey E. McQuade

Lindsey E. McQuade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8709743
    Abstract: The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: April 29, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Lindsey E. McQuade, Evgeny A. Nudler
  • Publication number: 20110201042
    Abstract: The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
    Type: Application
    Filed: December 17, 2008
    Publication date: August 18, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Lindsey E. McQuade, Evgeny A. Nudler