Patents by Inventor Linheng Li

Linheng Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130252338
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: May 20, 2013
    Publication date: September 26, 2013
    Applicant: Stowers Institute for Medical Research
    Inventors: John M. PERRY, Linheng LI, Justin C. GRINDLEY
  • Patent number: 8476071
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 2, 2013
    Assignee: Stowers Institute for Medical Research
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Publication number: 20120309088
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: August 9, 2012
    Publication date: December 6, 2012
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Patent number: 8263403
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: September 11, 2012
    Assignee: Stowers Institute for Medical Research
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Publication number: 20120115172
    Abstract: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine ?-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.
    Type: Application
    Filed: December 15, 2011
    Publication date: May 10, 2012
    Inventors: Xi HE, Tong Yin, Qiang Tian, Weiguo Tao, Leroy Hood, Linheng Li
  • Patent number: 8106166
    Abstract: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine ?-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: January 31, 2012
    Assignee: Stowers Institute for Medical Research
    Inventors: Xi He, Tong Yin, Qiang Tian, Weiguo Tao, Leroy Hood, Linheng Li
  • Publication number: 20110053266
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: June 16, 2010
    Publication date: March 3, 2011
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Publication number: 20100196337
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: April 23, 2008
    Publication date: August 5, 2010
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Publication number: 20100099186
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: October 23, 2009
    Publication date: April 22, 2010
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Publication number: 20080248026
    Abstract: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine ?-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.
    Type: Application
    Filed: March 17, 2008
    Publication date: October 9, 2008
    Inventors: Xi He, Tong Yin, Qiang Tian, Weiguo Tao, Leroy Hood, Linheng Li
  • Publication number: 20070036769
    Abstract: The present invention relates to mutant BMP intestinal stem cells (ISCs), with these mutant ISCs possessing an inactive Bmpr1a receptor in which BMP binding is substantially inhibited. The present invention relates to vectors which comprise mutant Bmpr1a nucleic acid sequences, whereby the vectors can be used to promote an increase in the number of ISCs in vivo or in vitro.
    Type: Application
    Filed: June 3, 2004
    Publication date: February 15, 2007
    Inventors: Linheng Li, Xi He
  • Publication number: 20060073117
    Abstract: The present invention relates to mutant hair follicle stem cells possessing an inactive Bmpr1a receptor, wherein such mutant hair follicle stem cells proliferate and undergo self-renewal. Additionally, the present invention relates to compositions and methods for induction of hair follicle stem cell proliferation in vivo and in vitro. The present invention also relates to mutant Bmpr1a organisms and tumor cells.
    Type: Application
    Filed: October 1, 2004
    Publication date: April 6, 2006
    Inventor: Linheng Li
  • Publication number: 20050271638
    Abstract: The present invention relates to mutant BMP intestinal stem cells (ISCs), with these mutant ISCs possessing an inactive Bmpr1a receptor in which BMP binding is substantially inhibited. The present invention relates to vectors which comprise mutant Bmpr1a nucleic acid sequences, whereby the vectors can be used to promote an increase in the number of ISCs in vivo or in vitro.
    Type: Application
    Filed: June 3, 2004
    Publication date: December 8, 2005
    Inventors: Linheng Li, Xi He
  • Publication number: 20040162679
    Abstract: The present invention relates to methods of associating nucleic acid sequences of unknown function with particular sub-populations, and methods of associating cells of unknown function with particular sub-populations. The method includes collecting hybridization data, developing a gene expression map, and comparing a nucleic acid sequence of unknown function to the gene expression map to determine in what sub-population the gene is expressed. The present invention also relates to kits, arrays, maps, isolated sequences, and clustered sequences.
    Type: Application
    Filed: May 5, 2003
    Publication date: August 19, 2004
    Inventor: Linheng Li
  • Publication number: 20040143863
    Abstract: The present invention relates to an isolated population of osteoblastic cells, which are characterized by cell surface markers N-cad+ and CD45−, with such osteoblastic cells used in vitro to promote and support growth of HSCs. Additionally, the present invention relates to vectors, which include a Bmpr1a nucleic acid sequence, recombination sites, and a plasmid, wherein the vectors can be used to promote an increase in the HSC population in vivo.
    Type: Application
    Filed: August 14, 2003
    Publication date: July 22, 2004
    Inventors: Linheng Li, Jiwang Zhang
  • Patent number: 6703198
    Abstract: The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: March 9, 2004
    Assignees: The University of Washington, The Children's Hospital of Philadelphia
    Inventors: Linheng Li, Leroy Hood, Ian D. Krantz, Nancy B. Spinner
  • Patent number: 6136952
    Abstract: The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: October 24, 2000
    Assignee: University of Washington
    Inventors: Linheng Li, Leroy Hood