Publication number: 20120003212
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Type:
Application
Filed:
February 18, 2011
Publication date:
January 5, 2012
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, WYETH LLC
Inventors:
FRANK S. WALSH, MARGARET M. ZALESKA, DAVID S. HOWLAND, ERIKA L.F. HOLZBAUR-HOWLAND, LIOUDMILA TCHISTIAKOVA, RIYEZ KARIM, PAMELA KELLEY, XIANG-YANG TAN, SEUNG POON KWAK, KAREN WALLACE, NICHOLAS WEBER, MENELAS N. PANGALOS, WILLIAM KELLEY
Patent number: 7910107
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Type:
Grant
Filed:
July 24, 2009
Date of Patent:
March 22, 2011
Assignees:
WYETH LLC, The Trustees of the University of Pennsylvania
Inventors:
Frank S. Walsh, Margaret M. Zaleska, David S. Howland, Erika L. F. Holzbaur-Howland, Lioudmila Tchistiakova, Riyez Karim, Pamela Kelley, William Kelley, legal representative, Xiang-Yang Tan, Seung Poon Kwak, Karen Wallace, Nicholas Weber, Menelas N. Pangalos
Publication number: 20090285827
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Type:
Application
Filed:
July 24, 2009
Publication date:
November 19, 2009
Applicants:
Wyeth, The Trustees of the University of Pennsylvania
Inventors:
Frank S. Walsh, Margaret M. Zaleska, David S. Howland, Erika L. F. Holzbaur-Howland, Lioudmila Tchistiakova, Riyez Karim, Pamela Kelley, William Kelley, Xiang-Yang Tan, Seung Poon Kwak, Karen Wallace, Nicholas Weber, Menelas N. Pangalos
Patent number: 7615213
Abstract: This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
Type:
Grant
Filed:
June 9, 2005
Date of Patent:
November 10, 2009
Assignee:
Wyeth
Inventors:
Marion T. Kasaian, Lioudmila Tchistiakova, Geertruida M. Veldman, Kimberly Ann Marquette, Xiang-Yang Tan, Debra D. Donaldson, Laura Long Lin, Tania Shane, Amy Sze Pui Tam, Eric Feyfant, Nancy L. Wood, Lori J. Fitz, Angela M. Widom, Kevin D. Parris, Samuel J. Goldman, Jose W. Saldanha