Patents by Inventor Louis B. Hersh

Louis B. Hersh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9044503
    Abstract: Methods for treatment and/or prevention of Alzheimer's disease comprising inactivating peripheral AP in serum to a reduce A(3 in the brain. Methods comprise expression of amyloid peptide inactivating enzyme on bone marrow cells; and coupling of amyloid peptide inactivating enzyme to hematopoietic cells.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: June 2, 2015
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Louis B. Hersh, Hanjun Guan
  • Patent number: 8632989
    Abstract: In one aspect, the present invention provides an isolated mutant insulin degrading enzyme (IDE) having an amino acid sequence that is at least 90% identical to SEQ ID NO:1 over its entire length and comprises at least one amino acid substitution at any of amino acid residues 332, 339, 341, 359, 360, 361, 374, 429, 609, 898, 899 or 901 of the sequence. The mutant IDE has a differential activity relative to that of wild-type IDE. Also provided is a polynucleotide encoding the polypeptide of the invention.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: January 21, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: David W. Rodgers, Louis B. Hersh, Nicholas Noinaj, Eun Suk Song
  • Patent number: 7807396
    Abstract: Estrogen has been shown to increase the expression and activity of amyloid peptide inactivating enzymes in the brain. Peptides have been shown to increase the activity of an amyloid peptide inactivating enzyme. Methods of identifying compounds for, and methods of treating patients with, Alzheimer's Disease is disclosed.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: October 5, 2010
    Inventor: Louis B. Hersh
  • Publication number: 20080317732
    Abstract: Methods for treatment and/or prevention of Alzheimer's disease comprising inactivating peripheral AP in serum to a reduce A(3 in the brain. Methods comprise expression of amyloid peptide inactivating enzyme on bone marrow cells; and coupling of amyloid peptide inactivating enzyme to hematopoietic cells.
    Type: Application
    Filed: August 26, 2005
    Publication date: December 25, 2008
    Inventors: Louis B. Hersh, Hanjun Guan
  • Publication number: 20030165481
    Abstract: Estrogen has been shown to increase the expression and activity of amyloid peptide inactivating enzymes in the brain. Peptides have been shown to increase the activity of an amyloid peptide inactivating enzyme. A method of treating patients with Alzheimer's Disease is disclosed.
    Type: Application
    Filed: June 3, 2002
    Publication date: September 4, 2003
    Inventor: Louis B. Hersh
  • Publication number: 20030083277
    Abstract: The peptidase insulin degrading enzyme (IDE) has been shown to cleave A&bgr; peptides. Cleavage of A&bgr;1-42 by recombinant IDE abolishes its cell toxicity. Recombinant IDE is expressed on the surface of cells or secreted from cells in plaque forming regions of the brain. Primary hippocampal and cortical cells are treated with A&bgr; peptides in the presence or absence of IDE and cell toxicity measured. Cells are recombinantly engineered to express IDE on the cell surface or secrete it. The membrane bound and secreted forms of IDE are then expressed in a mammal.
    Type: Application
    Filed: February 26, 2001
    Publication date: May 1, 2003
    Inventor: Louis B. Hersh
  • Patent number: 5200426
    Abstract: The present disclosure relates to inhibitors of neutral endopeptidase (NEP) which are proposed as novel agents for the treatment of CALLA+ positive cancers as well as other conditions such as hypertension.
    Type: Grant
    Filed: August 14, 1990
    Date of Patent: April 6, 1993
    Assignee: Board of Regents, The University of Texas
    Inventors: Louis B. Hersh, R. C. Bateman, Jr.