Patents by Inventor Louis M. Weiner

Louis M. Weiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115670
    Abstract: Systems and methods are disclosed for the treatment of cancer. Specifically, techniques are disclosed for treating cancer through the administration of genetically modified immune cells that overexpress fibroblast activation protein. In other embodiments, the techniques include the treatment of cancer through the administration of fibroblast activation protein inhibitors to the tumor site.
    Type: Application
    Filed: January 27, 2022
    Publication date: April 11, 2024
    Inventors: Louis M. Weiner, Allison Fitzgerald
  • Publication number: 20200319163
    Abstract: Methods and compositions are provided for preventing the loss of cell surface adhesion molecules and thus prevent or delay acquisition of a ADCC resistance phenotype mediated by lower expression of several cell surface molecules that contribute to cell:cell interactions and immune synapse formation including tumor target antigens, MHC Class I/II molecules and cell adhesion proteins. In certain embodiments, the method and composition blocks STAT1 and/or p-STAT1. In another embodiment, the method and composition blocks HATp300 and/or PCAF. In another embodiment the method and composition blocks S100a9/a8. In yet other embodiments, cocktails of combinations of inhibitors of two or more of p-STAT1, S100a8/a9, HAT p300, and PCAF are employed to reduce, reverse or inhibit development of ADCC resistant phenotypes.
    Type: Application
    Filed: March 30, 2020
    Publication date: October 8, 2020
    Inventor: Louis M. Weiner
  • Patent number: 10450613
    Abstract: Compositions and methods for the treatment and diagnosis of cancer are disclosed.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: October 22, 2019
    Assignee: Fox Chase Cancer Center
    Inventors: Igor Astsaturov, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner
  • Patent number: 9677072
    Abstract: The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the group consisting of BLOC1S1, CDC2L1, CNOT1, DDX54, EIF3I, FANCG, FBP1, IER2, KIF1A, LCK, NR2F1, PNRC1, POLR2A, POLR2B, POLR2C, PRPF6, PSMB4, PSMC5, PSMD1, RPS2, SCNN1A, SF3A3, TAF2, TOB1 and TSC22D4.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 13, 2017
    Assignee: Georgetown University
    Inventors: Louis M. Weiner, Rochelle E. Nasto, Robert Clarke, Erica Golemis, Ilya Serebriiskii
  • Patent number: 9567641
    Abstract: A target substance used for combination treatment with an anti-c-Met antibody, a pharmaceutical composition for combination administration for preventing and/or treating cancer including an anti-c-Met antibody and an inhibitor against the target substance as active ingredients, a method for preventing and/or treating cancer including co-administering an anti-c-Met antibody and an inhibitor against the target substance, and a method for screening a drug for preventing and/or treating cancer using the target substance.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: February 14, 2017
    Assignees: SAMSUNG ELECTRONICS CO., LTD., GEORGETOWN UNIVERSITY
    Inventors: Bo Gyou Kim, Shangzi Wang, Ji Min Lee, Kyung Ah Kim, Louis M. Weiner
  • Publication number: 20170002426
    Abstract: Compositions and methods for the treatment and diagnosis of cancer are disclosed.
    Type: Application
    Filed: June 2, 2016
    Publication date: January 5, 2017
    Inventors: Igor Astsaturov, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner
  • Patent number: 9534050
    Abstract: Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided. The antibodies may be used in methods for treating tumors and for inhibiting angiogenesis in tumors.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: January 3, 2017
    Assignee: Institute for Cancer Research
    Inventors: Hossein Borghaei, Louis M. Weiner
  • Publication number: 20150353928
    Abstract: The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the group consisting of BLOC1S1, CDC2L1, CNOT1, CYR61, DDX54, EIF3I, FANCG, FBP1, IER2, KIF1A, LCK, NR2F1, PNRC1, POLR2A, POLR2B, POLR2C, PRPF6, PSMB4, PSMC5, PSMD1, PTK7, RPS2, SCNN1A, SF3A3, TAF2, TOB1, TSC22D4.
    Type: Application
    Filed: September 14, 2012
    Publication date: December 10, 2015
    Applicants: Georgetown University, Fox Chase Cancer Center
    Inventor: Louis M. WEINER
  • Patent number: 9101631
    Abstract: Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: August 11, 2015
    Assignees: Georgetown University, Fox Chase Cancer Center
    Inventors: Vladimir Ratushny, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner, Igor Astsaturov, Andrew Godwin
  • Patent number: 8980258
    Abstract: Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: March 17, 2015
    Assignees: The Regents of the University of California, Fox Chase Cancer Center
    Inventors: Gregory P Adams, Eva M. Horak, Louis M. Weiner, James D. Marks
  • Publication number: 20150064190
    Abstract: Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided. The antibodies may be used in methods for treating tumors and for inhibiting angiogenesis in tumors.
    Type: Application
    Filed: October 15, 2014
    Publication date: March 5, 2015
    Inventors: Hossein Borghaei, Louis M. Weiner
  • Publication number: 20150010575
    Abstract: A target substance used for combination treatment with an anti-c-Met antibody, a pharmaceutical composition for combination administration for preventing and/or treating cancer including an anti-c-Met antibody and an inhibitor against the target substance as active ingredients, a method for preventing and/or treating cancer including co-administering an anti-c-Met antibody and an inhibitor against the target substance, and a method for screening a drug for preventing and/or treating cancer using the target substance.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Inventors: Bo Gyou KIM, Shangzi Wang, Ji Min Lee, Kyung Ah Kim, Louis M. Weiner
  • Patent number: 8883978
    Abstract: Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided. The antibodies may be used in methods for treating tumors and for inhibiting angiogenesis in tumors.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: November 11, 2014
    Assignee: Institute for Cancer Research
    Inventors: Hossein Borghaei, Louis M. Weiner
  • Publication number: 20130331294
    Abstract: Compositions and methods for the treatment and diagnosis of cancer are disclosed.
    Type: Application
    Filed: July 15, 2013
    Publication date: December 12, 2013
    Applicant: Fox Chase Cancer Center
    Inventors: Igor Astsaturov, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner
  • Patent number: 8580263
    Abstract: Anti-EGFR family member antibodies and bispecific antibodies comprising one or more anti-EGFR family member antibodies are disclosed. These antibodies can be used to advantage to specifically target forms of cancer associated with the overexpression of members of the EGFR protein family.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: November 12, 2013
    Assignees: The Regents of the University of California, Fox Chase Cancer Center
    Inventors: Gregory P. Adams, Eva M. Horak, Louis M. Weiner, James D. Marks
  • Publication number: 20130058935
    Abstract: Antibodies that specifically bind to an epitope on the extracellular domain of TEM7R are provided. Nucleic acids encoding such antibodies and cells capable of expressing such antibodies are also provided. The antibodies may be used in methods for treating tumors and for inhibiting angiogenesis in tumors.
    Type: Application
    Filed: May 11, 2011
    Publication date: March 7, 2013
    Applicant: Fox Chase Cancer Center
    Inventors: Hossein Borghaei, Louis M. Weiner
  • Patent number: 8329873
    Abstract: Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: December 11, 2012
    Assignees: The Regents of the University of California, Fox Chase Cancer Center
    Inventors: Gregory P. Adams, Eva M. Horak, Louis M. Weiner, James D. Marks
  • Publication number: 20110281935
    Abstract: Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
    Type: Application
    Filed: December 14, 2009
    Publication date: November 17, 2011
    Inventors: Vladimir Ratushny, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner, Igor Astsaturov, Andrew Godwin
  • Publication number: 20110033461
    Abstract: Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
    Type: Application
    Filed: March 12, 2009
    Publication date: February 10, 2011
    Inventors: Vladimir Ratushny, Erica Golemis, Igor Astsaturov, Iiya G. Serebriiskii, Louis M. Weiner
  • Publication number: 20100239656
    Abstract: Compositions and methods for the treatment and diagnosis of cancer are disclosed.
    Type: Application
    Filed: May 10, 2010
    Publication date: September 23, 2010
    Inventors: Igor Astsaturov, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner