Patents by Inventor Luciano Lattuada

Luciano Lattuada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Manufacturing process for preparing gadoteridol
    Patent number: 11905257
    Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: February 20, 2024
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Fretta, Luciano Lattuada, Gabriele Meli
  • MANUFACTURING PROCESS FOR PREPARING GADOTERIDOL
    Publication number: 20230391735
    Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.
    Type: Application
    Filed: December 1, 2021
    Publication date: December 7, 2023
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Luciano LATTUADA, Gabriele MELI
  • Dimeric contrast agents
    Patent number: 11401262
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: August 2, 2022
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • PHARMACEUTICAL COMPOSITIONS COMPRISING GD-COMPLEXES AND POLYARYLENE ADDITIVES
    Publication number: 20220062444
    Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).
    Type: Application
    Filed: December 17, 2019
    Publication date: March 3, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Giuseppe FERRAUTO, Eliana GIANOLIO, Luciano LATTUADA, Alessandro MAIOCCHI
  • GADOLINIUM BEARING PCTA-BASED CONTRAST AGENTS
    Publication number: 20210196840
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Application
    Filed: March 11, 2021
    Publication date: July 1, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
  • Contrast agents
    Patent number: 11021451
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: June 1, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Contrast agents
    Patent number: 11007283
    Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 18, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • Gadolinium bearing PCTA-based contrast agents
    Patent number: 10973934
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: April 13, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Napolitano, Luciano Lattuada, Zsolt Baranyai, Nicole Guidolin, Giuseppe Marazzi
  • DIMERIC CONTRAST AGENTS
    Publication number: 20210024500
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: October 1, 2020
    Publication date: January 28, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • Dimeric contrast agents
    Patent number: 10882849
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 5, 2021
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada
  • Synthesis of NIR fluorescent probe
    Patent number: 10870649
    Abstract: The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: December 22, 2020
    Assignee: BRACCO IMAGING SPA
    Inventors: Luciano Lattuada, Federica Buonsanti, Federico Crivellin, Fulvio Ferretti, Federico Maisano, Laura Orio, Lorena Pizzuto
  • GADOLINIUM BEARING PCTA-BASED CONTRAST AGENTS
    Publication number: 20200376145
    Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
    Type: Application
    Filed: August 6, 2019
    Publication date: December 3, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
  • Mechanochemical synthesis of radiographic agents intermediates
    Patent number: 10836710
    Abstract: The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: November 17, 2020
    Assignee: BRACCO IMAGING SPA
    Inventors: Alessandro Barge, Francesca Baricco, Giancarlo Cravotto, Roberta Fretta, Luciano Lattuada
  • Solid phase synthesis of NIR fluorescent probe
    Patent number: 10822371
    Abstract: The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 3, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Raphael Campanella, Anthony Clouet, Luciano Lattuada
  • DIMERIC CONTRAST AGENTS
    Publication number: 20200331893
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: July 25, 2019
    Publication date: October 22, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA
  • CONTRAST AGENTS
    Publication number: 20200325108
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
  • SOLID PHASE SYNTHESIS OF NIR FLUORESCENT PROBE
    Publication number: 20200317722
    Abstract: The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
    Type: Application
    Filed: December 5, 2018
    Publication date: October 8, 2020
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Raphael CAMPANELLA, Anthony CLOUET, Luciano LATTUADA
  • Dimeric contrast agents
    Patent number: 10793533
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: October 6, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
  • Contrast agents
    Patent number: 10781188
    Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 22, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
  • MECHANOCHEMICAL SYNTHESIS OF RADIOGRAPHIC AGENTS INTERMEDIATES
    Publication number: 20200079728
    Abstract: The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 12, 2020
    Applicant: BRACCO IMAGING SPA
    Inventors: Alessandro BARGE, Francesca BARICCO, Giancarlo CRAVOTTO, Roberta FRETTA, Luciano LATTUADA