Abstract: The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.

Abstract: Methods are disclosed for treating periodontal disease, peri-implantitis, or to preserve a tooth socket in a subject. These methods include selecting a subject with periodontal disease, peri-implantitis, or in need of tooth socket preservation; and locally administering into the periodontium of the subject a therapeutically effective amount of a tissue-nonspecific alkaline phosphatase (TNAP) polypeptide, or a nucleic acid molecule encoding the recombinant TNAP polypeptide. Methods are also disclosed for i) promoting alveolar bone regeneration in the subject; ii) increasing attachment of a periodontal ligament to a root surface of a tooth in the subject; iii) increasing cementum formation; and/or iv) increasing mineralization in a tooth in the subject. Pharmaceutical compositions are also disclosed that are of use in these methods.

Abstract: Described herein are methods of treating atherosclerosis, including administering a tissue-nonspecific alkaline phosphatase (TNAP) inhibitor to a patient. Described herein are also methods of reducing microcalcifications in an atherosclerotic plaque, including administering a TNAP inhibitor to a patient. Described herein are also methods of preventing, arresting, or reducing the development of plaque calcifications in a patient, including administering a TNAP inhibitor to a patient.

Abstract: The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.

Abstract: The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.

Abstract: A new and useful fire starter system, method and system components are that can be transported by a person (e.g. a hiker) in the wilderness and used to start a fire for that person.

Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Abstract: The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.

Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Abstract: The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.

Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Abstract: A new and useful system, method and system components are provided, for helping a vehicle operator to ease his/her driving, when is driving at certain speed and is approaching from at a substantial distance to a street intersection so that the decision of whether the vehicle speed should be reduced or maintained can be made at convenient time. By providing with anticipated information relative to an imminent light change, a vehicle operator will have the sufficient time to react calmly to any situation that could put at risk his/her own integrity and/or the integrity of some others. This new and improved traffic control system is designed in a manner that is efficient and effective, in a manner that is useful and helpful, in a manner that is designed in a compact and low profile design; It is designed the best and the most simple way to provide and give to a vehicle operator a better, safely, relaxing and a pleasant driving.

Abstract: The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.

Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Abstract: A new and useful system, method and system components are provided, for helping a vehicle operator to ease his/her driving, when is driving at certain speed and is approaching from at a substantial distance to a street intersection so that the decision of whether the vehicle speed should be reduced or maintained can be made at convenient time. By providing with anticipated information relative to an imminent light change, a vehicle operator will have the sufficient time to react calmly to any situation that could put at risk his/her own integrity and/or the integrity of some others. This new and improved traffic control system is designed in a manner that is efficient and effective, in a manner that is useful and helpful, in a manner that is designed in a compact and low profile design; It is designed the best and the most simple way to provide and give to a vehicle operator a better, safely, relaxing and a pleasant driving.

Abstract: A new and useful fire starter system, method and system components are that can be transported by a person (e.g. a hiker) in the wilderness and used to start a fire for that person.

Abstract: A new and useful vacuum apparatus is provided, for sweeping and cleaning a residential and commercial spaces, in a manner that is efficient and effective and a manner that minimize effort and time. The apparatus includes a flexible container that encloses some of the vacuum, sweeping and cleaning components that are part of a vacuum system, the flexible container configured to be worn by a person operating the apparatus, and having a flexibility that enables it to conform to the contour of the back of a person wearing the flexible container, and the flexible container is also configured to enable certain components of the vacuum system to be located outside of the container when the container is being worn by a person operating the vacuum system.

Abstract: A new and useful system, method and system components are provided, for helping a person to survive in certain situations at different scenarios when find him/herself trapped on it, while performing outdoor activities, in a manner that is efficient and effective, and in a manner that is designed in a compact and a low profile design, in a manner that is lightweight, comfortable and easy to wear it, in a manner that is handy and helpful. It has been designed to help a person to improve his/her skills and/or increase his/her opportunity of survive while trapped in a difficult situation.

Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.