Patents by Inventor Luiz Belardinelli

Luiz Belardinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINING ELECTRONIC MONITORING WITH INHALED PHARMACOLOGICAL THERAPY TO MANAGE CARDIAC ARRHYTHMIAS INCLUDING ATRIAL FIBRILLATION
    Publication number: 20170238866
    Abstract: Disclosed herein are methods of treating cardiac arrhythmia with electronic monitoring in a timely manner. Also disclosed herein are systems for electronic monitoring of cardiac arrhythmia.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 24, 2017
    Inventors: Rangachari NARASIMHAN, Luiz BELARDINELLI, Carlos A. SCHULER
  • Compositions and methods of treating pulmonary hypertension
    Patent number: 9549926
    Abstract: Provided are formulations comprising therapeutically effective amounts of ambrisentan or a pharmaceutically acceptable salt thereof and tadalafil or a pharmaceutically acceptable salt thereof and methods of treating and/or preventing pulmonary hypertension by administration of the formulations.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: January 24, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Hunter Campbell Gillies, Faquan Liang, John Shryock, Suya Yang
  • COMPOSITIONS AND METHODS OF TREATING PULMONARY HYPERTENSION
    Publication number: 20160346280
    Abstract: Provided are formulations comprising therapeutically effective amounts of ambrisentan or a pharmaceutically acceptable salt thereof and tadalafil or a pharmaceutically acceptable salt thereof and methods of treating and/or preventing pulmonary hypertension by administration of the formulations.
    Type: Application
    Filed: August 9, 2016
    Publication date: December 1, 2016
    Inventors: Luiz Belardinelli, Hunter Campbell Gillies, Faquan Liang, John Shryock, Suya Yang
  • Myocardial perfusion imaging methods and compositions
    Patent number: 9289446
    Abstract: A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: March 22, 2016
    Assignee: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Mitchell Rosner
  • Methods of myocardial perfusion imaging
    Patent number: 9163057
    Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: October 20, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
  • MYOCARDIAL PERFUSION IMAGING METHODS AND COMPOSITIONS
    Publication number: 20150283162
    Abstract: A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
    Type: Application
    Filed: November 4, 2014
    Publication date: October 8, 2015
    Inventors: Luiz Belardinelli, Mitchell Rosner
  • METHODS OF TREATING PATIENTS HAVING IMPLANTABLE CARDIAC DEVICES
    Publication number: 20150283149
    Abstract: Described herein are methods for reducing ventricular tachycardia/ventricular fibrillation (VT/VF), methods for reducing implantable cardioverter-defibrillator device (ICD) shocks, methods for reducing CV hospitalization, ER visits, CV death or SCD in patients having implantable cardiac devices or CRT, and methods for reducing the use of ICD in a human patient without prior VT/VF, by administering an effective amount of the potent and selective late sodium ion channel blocker Compound 1.
    Type: Application
    Filed: March 20, 2015
    Publication date: October 8, 2015
    Inventors: Luiz Belardinelli, Ewa Prokopczuk, Dewan Zeng
  • Compound and methods for treating long QT syndrome
    Patent number: 9126989
    Abstract: Described herein is a method of treating long QT syndrome by administration of an effective amount of a potent and selective late sodium ion channel blocker.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: September 8, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Sridharan Rajamani, Dewan Zeng
  • Methods of treating hypertrophic cardiomyopathy
    Patent number: 9125916
    Abstract: The present disclosure relates to a compound of formula (I) or formula (II) or a pharmaceutically acceptable salt thereof, for use in the treatment of hypertrophic cardiomyopathy.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: September 8, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Ramin Farzaneh-Far
  • Method of treating atrial fibrillation
    Patent number: 9056108
    Abstract: The present invention relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof. Also provided are methods for modulating ventricular and atrial rhythm and rate. This invention also relates to pharmaceutical formulations that are suitable for such combined administration.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: June 16, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Charles Antzelevitch, Luiz Belardinelli, Alexander Burashnikov, John Shryock, Dewan Zeng
  • N-pyrazole Areceptor agonists
    Patent number: 9045519
    Abstract: The present disclosure provides a process for the preparation of 2-adenosine N-pyrazole compounds exemplified by the structure shown below that are potent and selective agonists for A2A adenosine receptor, compositions comprising these compounds, and methods for using these compound to stimulate mammalian coronary vasodilatation for imaging the heart.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 2, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Jeff A. Zablocki, Elfatih O. Elzein, Venkata P. Palle, Luiz Belardinelli
  • COMBINATION THERAPY FOR TREATING PULMONARY HYPERTENSION
    Publication number: 20150125546
    Abstract: Method of treating and/or preventing pulmonary arterial hypertension comprising administering effective amounts of ambrisentan or a pharmaceutically acceptable salt thereof and riociguat or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Applicant: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Hunter Campbell Gillies, Faquan Liang, Lina Yao
  • COMBINATION THERAPIES USING LATE SODIUM ION CHANNEL BLOCKERS AND POTASSIUM ION CHANNEL BLOCKERS
    Publication number: 20150045305
    Abstract: Described herein is a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising administration of an effective amount of one or more of a potassium channel blocker and an effective amount of one or more of a late sodium channel blocker. Also provided are methods for modulating ventricular and atrial rhythm and rate. Also provided are pharmaceutical formulations that are suitable for such combined administration.
    Type: Application
    Filed: January 25, 2013
    Publication date: February 12, 2015
    Inventors: Luiz Belardinelli, Sridharan Rajamani
  • COMPOUND AND METHODS FOR TREATING LONG QT SYNDROME
    Publication number: 20150038489
    Abstract: Described herein is a method of treating long QT syndrome by administration of an effective amount of a potent and selective late sodium ion channel blocker
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Applicant: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Sridharan Rajamani, Dewan Zeng
  • METHODS OF TREATING HYPERTROPHIC CARDIOMYOPATHY
    Publication number: 20150038487
    Abstract: The present disclosure relates to a compound of formula (I) or formula (II) or a pharmaceutically acceptable salt thereof, for use in the treatment of hypertrophic cardiomyopathy.
    Type: Application
    Filed: July 28, 2014
    Publication date: February 5, 2015
    Inventors: Luiz Belardinelli, Ramin Farzaneh-Far
  • METHODS OF MYOCARDIAL PERFUSION IMAGING
    Publication number: 20150023867
    Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 22, 2015
    Applicant: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
  • METHOD OF TREATING ATRIAL FIBRILLATION
    Publication number: 20140364417
    Abstract: The present disclosure relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a therapeutically effective amount of ivabradine or a pharmaceutically acceptable salt thereof and a therapeutically effective amount of ranolazine. Also provided are methods for modulating ventricular and atrial rate. This disclosure also relates to pharmaceutical formulations that are suitable for such combined administration.
    Type: Application
    Filed: May 2, 2014
    Publication date: December 11, 2014
    Inventors: Luiz Belardinelli, Richard Verrier, Dewan Zeng
  • Myocardial perfusion imaging methods and compositions
    Patent number: 8906878
    Abstract: A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: December 9, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Mitchell Rosner
  • COMBINATION THERAPY FOR THE TREATMENT OF ARRHYTHMIAS OR HEART FAILURE
    Publication number: 20140329755
    Abstract: The present invention relates to method of treating arrhythmias or heart failure comprising co-administration of a late INa inhibitor and a CAMK II inhibitor.
    Type: Application
    Filed: April 30, 2014
    Publication date: November 6, 2014
    Applicant: Gilead Sciences, Inc.
    Inventors: Luiz Belardinelli, Peidong Fan, Faquan Liang, Lina Yao
  • METHOD OF TREATING ATRIAL FIBRILLATION
    Publication number: 20140323493
    Abstract: The present invention relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof. Also provided are methods for modulating ventricular and atrial rhythm and rate. This invention also relates to pharmaceutical formulations that are suitable for such combined administration.
    Type: Application
    Filed: March 20, 2014
    Publication date: October 30, 2014
    Applicant: Gilead Sciences, Inc.
    Inventors: Charles Antzelevitch, Luiz Belardinelli, Alexander Burashnikov, John Shryock, Dewan Zeng