Patents by Inventor Lutz Weber

Lutz Weber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180029037
    Abstract: This document provides methods and devices for metering fluids. In some cases, the methods and devices include intersecting channels that include capillary-stop geometries at each intersection point that guides the fluids on a desired path, which is controlled by the opening and closing of valves. For example, a metering channel can intersect a loading channel and intersect an outflow channel and a metering portion can be defined by the geometry of the metering channel between the intersection points.
    Type: Application
    Filed: October 9, 2017
    Publication date: February 1, 2018
    Applicant: Daktari Diagnostics, Inc.
    Inventors: Lee Zamir, Aaron Oppenheimer, Lutz Weber
  • Publication number: 20170303376
    Abstract: A fastener system for ignition prevention triggered by a lightning strike. The fastener has a fastener body and a fastener head, and a fastening member configured to be mounted on a portion of the fastener body, wherein the fastener and the fastening member are configured to fasten at least a first part and a second part between the fastener head and the fastening member, and the fastener comprises an electrically insulating material. A structure comprises the fastener system, the first part that faces an outside from where the lightning strike may hit the first part and the second part.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 19, 2017
    Inventors: Michael Kaste, Lutz Weber
  • Patent number: 9782774
    Abstract: This document provides methods and devices for metering fluids. In some cases, the methods and devices include intersecting channels that include capillary-stop geometries at each intersection point that guides the fluids on a desired path, which is controlled by the opening and closing of valves. For example, a metering channel can intersect a loading channel and intersect an outflow channel and a metering portion can be defined by the geometry of the metering channel between the intersection points.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: October 10, 2017
    Assignee: Daktari Diagnostics, Inc.
    Inventors: Lee Zamir, Aaron Oppenheimer, Lutz Weber
  • Publication number: 20170203293
    Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 20, 2017
    Applicant: Daktari Diagnostics, Inc.
    Inventors: Aaron Oppenheimer, Lutz Weber, Matthias Kronsbein, Zachary Jarrod Traina, Philip Charles Walker, Andrew Boyce, Adam Casey
  • Publication number: 20170168074
    Abstract: The present invention relates to a method for diagnosing a G-protein coupled receptor-related disease in one or more target cells, comprising: selecting a G-protein coupled receptor, the receptor being characterized in that it is: (i) differentially expressed in the target cells as compared to healthy control cells, wherein the expression level in the target cells is at least 10 times the expression level in the control cells; (ii) activated by a peptide ligand or a protein ligand; and (iii) upon activation by binding of a ligand efficiently internalized into the one or more target cells together the peptide ligand or protein ligand, wherein an internalization of at least 30% of the G-protein coupled receptor initially present in the cell membrane of the one or more target cells within less than 30 minutes after activation is indicative for the diagnosis of a G-protein coupled receptor-related disease.
    Type: Application
    Filed: September 30, 2014
    Publication date: June 15, 2017
    Inventors: Robert RENNERT, David KOSEL, Lutz WEBER
  • Publication number: 20170157611
    Abstract: A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.
    Type: Application
    Filed: June 22, 2015
    Publication date: June 8, 2017
    Inventor: Lutz WEBER
  • Publication number: 20170157608
    Abstract: A flow cell having at least one storage zone connected to a duct for conducting fluid out of, into or/and through the storage zone. The duct includes a duct section which is delimited by a substrate and a film joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The film covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall which is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.
    Type: Application
    Filed: June 22, 2015
    Publication date: June 8, 2017
    Applicant: Thinxxs Microtechnology AG
    Inventor: Lutz WEBER
  • Publication number: 20170157150
    Abstract: The present invention relates to pharmaceutical solid dosage forms for oral administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.
    Type: Application
    Filed: February 22, 2017
    Publication date: June 8, 2017
    Applicant: Alphaptose GmbH
    Inventors: Wolfgang Richter, Lutz Weber
  • Patent number: 9644794
    Abstract: An arrangement composed of a flow cell and an apparatus for operating the flow cell, wherein the flow cell has at least two layers, between which the operator device can produce a cavity structure or alter an existing cavity structure with curvature of at least one of the two layers.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: May 9, 2017
    Assignee: THINXXS MICROTECHNOLOGY AG
    Inventor: Lutz Weber
  • Patent number: 9610579
    Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: April 4, 2017
    Assignee: Daktari Diagnostics, Inc.
    Inventors: Aaron Oppenheimer, Lutz Weber, Matthias Kronsbein, Zachary Jarrod Traina, Philip Charles Walker, Andrew Boyce, Adam Casey
  • Publication number: 20160207041
    Abstract: A method for forming a microchannel or microfluidic reservoir is described. Methods provided herein include applying a covering over a recess formed in a substrate and bonding the covering to the substrate along seams. Methods provided herein use a substrate having elevated edge regions bordering the recess that project from the surface of the substrate. Bonding seams nm a distance from the elevated edge regions of the recess such that the covering and the elevated edge regions are pressed against each other. Devices for bonding substrates and coverings to make microchannels and microfluidic reservoirs are also provided herein. Devices provided herein can include pressing elements for holding the substrate and the covering together. Pressing elements provided herein can include recesses and/or elastic layers positioned opposite to one or more recesses in a substrate.
    Type: Application
    Filed: September 10, 2014
    Publication date: July 21, 2016
    Inventor: Lutz WEBER
  • Publication number: 20160167047
    Abstract: A microfluidic flow cell having a dry substance arranged within the flow cell in a cavity for interaction with a fluid located in the cavity. A passage opens into the cavity and a carrier element that can be inserted into the passage is provided with a carrier surface for the dry substance, adjoining the cavity.
    Type: Application
    Filed: July 4, 2014
    Publication date: June 16, 2016
    Inventors: Lutz WEBER, Tina RĂ–SER
  • Patent number: 9211538
    Abstract: The invention relates to a microfluid storage device having at least one supply chamber (5) formed by bulging a film (7) or membrane (19), a target break point (10) for forming an opening in the supply chamber (5), and a transport path (9) leading from the supply chamber (5) to an opening (11) in the supply chamber, for example, an interface between the storage device and a microfluid processing unit (2). According to the invention, the initially closed transport path (9) may be opened to form a transport channel (15) corresponding to the fluid stream escaping from the supply chamber (5), preferably by the escaping fluid itself, which allows the fluid to be removed from the storage device in a bubble-free manner.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: December 15, 2015
    Assignee: THINXXS MICROTECHNOLOGY AG
    Inventor: Lutz Weber
  • Publication number: 20150290642
    Abstract: A flow cell and a method for connecting components of a microfluidic flow cell, in particular for integrating component parts into a carrier structure of the flow cell, in which a gap is formed between the components to be connected. The gap is filled with a solvent. The material of at least one component bordering the gap dissolves in the solvent and the material completely fills the width of the gap and partially fills the height thereof after evaporation of the solvent.
    Type: Application
    Filed: December 5, 2013
    Publication date: October 15, 2015
    Applicant: thinXXS Microtechnology AG
    Inventor: Lutz Weber
  • Patent number: 9149802
    Abstract: A flow cell with a temperature-control chamber for holding a fluid, the temperature of which is to be controlled, whose boundary wall is formed at least partially by a thin foil for transferring heat between a temperature-control element and the fluid. The foil has several layers joined with one another, such that the layer that faces the fluid is a plastic layer, and at least one other layer is of a metal.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: October 6, 2015
    Assignee: THINXXS MICROTECHNOLOGY AG
    Inventor: Lutz Weber
  • Publication number: 20150238626
    Abstract: The present invention refers to neuropeptide Y receptor 1 (NPY-1) binding ligands linked to cytotoxic molecules and their use for the treatment of cancer and other diseases.
    Type: Application
    Filed: September 17, 2013
    Publication date: August 27, 2015
    Inventors: Annette G. Beck-Sickinger, Lutz Weber, Wolfgang Richter, Verena Ahrens, Robert Rennert
  • Patent number: 9108192
    Abstract: A micro reservoir, particularly for integration in a microfluidic flow cell, with a storage space for receiving a fluid and being in connection with an outlet duct for the fluid, wherein a cancelable lock for the fluid is formed. A mechanism is provided for canceling the lock without pressure of the fluid acting on the lock. The mechanism preferably mechanically destroys the lock.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: August 18, 2015
    Assignee: THINXXS MICROTECHNOLOGY AG
    Inventors: Lutz Weber, Michel Neumeier, Stefan Keck
  • Publication number: 20150190802
    Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.
    Type: Application
    Filed: January 6, 2015
    Publication date: July 9, 2015
    Inventors: Aaron Oppenheimer, Lutz Weber, Matthias Kronsbein, Zachary Jarrod Traina, Philip Charles Walker, Andrew Boyce, Adam Casey
  • Patent number: 9045414
    Abstract: The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: June 2, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christoph Burdack, Cedric Kalinski, Vladimir Khazak, Gunther Ross, Lutz Weber
  • Patent number: 9005546
    Abstract: A flow cell having a support surface, and an integrated fluid reservoir made of two foil layers arranged on the support surface and joined with each other to enclose a storage space and a transport channel. The transport channel extends from a burst point that closes the storage space to a connecting opening and can be opened by fluid flowing from the storage space. A first of the foil layers of the fluid reservoir faces away from the support surface and projects beyond a second of the foil layers of the fluid reservoir that faces the support surface, and is bonded with the support surface in a projecting region.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: April 14, 2015
    Assignee: Thinxxs Microtechnology AG
    Inventor: Lutz Weber