Patents by Inventor M. DeZwaan Todd

M. DeZwaan Todd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the identification of inhibitors of C4 Long Chain Base Hydroxylase activity in plants
    Publication number: 20040265836
    Abstract: The present inventors have discovered that LCBH is essential for plant growth. Specifically, the inhibition of LCBH gene expression in Arabidopsis results in reduced growth and abnormal development. Thus, LCBH is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of a LCBH in the presence and absence of a compound, where an alteration of LCBH activity in the presence of the compound indicates the compound as a candidate for a herbicide.
    Type: Application
    Filed: June 30, 2003
    Publication date: December 30, 2004
    Inventors: M. DeZwaan Todd, Lining Guo, Keith Davis, Adel Zayed, Susanne Kjemtrup, Douglas Boyes, Brenda Warrick, Joseph Cameron Mitchell, Robert Ascenzi, Carol Hamilton, Jeffrey Woessner, Jorn Gorlach, Neil Hoffman, Rao Mulpuri
  • Methods for the identification of inhibitors of CAX1-like Ca+2/H+ antiporter activity in plants
    Publication number: 20040229208
    Abstract: The present inventors have discovered that CAX1-like H+/Ca+2 antiporter is essential for plant growth. Specifically, the inhibition of CAX1-like H+/Ca+2 antiporter gene expression in plant seedlings results in reduced growth and abnormal development. Thus, CAX1-like H+/Ca+2 antiporter is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of a CAX1-like H+/Ca+2 antiporter in the presence and absence of a compound, where an alteration of CAX1-like H+/Ca+2 antiporter activity in the presence of the compound indicates the compound as a candidate for a herbicide.
    Type: Application
    Filed: May 12, 2003
    Publication date: November 18, 2004
    Inventors: M. DeZwaan Todd, Lining Guo, Keith Davis, Adel Zayed, Susanne Kjemtrup, Douglas Boyes, Brenda Warrick, Joseph Cameron Mitchell, Robert Ascenzi, Carol Hamilton, Jeffrey Woessner, Jorn Gorlach, Neil Hoffman, Rao Mulpuri
  • Methods for the identification of inhibitors of Methylenetetrahydrofolate reductase as antibiotics
    Publication number: 20030228650
    Abstract: The present inventors have discovered that Methylenetetrahydrofolate reductase is essential for fungal pathogenicity. Specifically, the inhibition of Methylenetetrahydrofolate reductase gene expression in fungi results in an inability to form lesions and non-pathogenicity. Thus, Methylenetetrahydrofolate reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Methylenetetrahydrofolate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: May 13, 2003
    Publication date: December 11, 2003
    Inventors: Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, M. DeZwaan Todd, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger
  • Methods for the identification of inhibitors of chitin synthase 2 as antibiotics
    Publication number: 20030228645
    Abstract: The present inventors have discovered that Chitin Synthase 2 is essential for fungal pathogenicity. Specifically, the inhibition of Chitin Synthase 2 gene expression in fungi results in no signs of successful infection or lesions. Thus, Chitin Synthase 2 can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Chitin Synthase 2 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: May 12, 2003
    Publication date: December 11, 2003
    Inventors: Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, M. DeZwaan Todd, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro