Patents by Inventor M. Reza Ghadiri

M. Reza Ghadiri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of cyclic peptides for treating and preventing atherosclerosis
    Patent number: 10092620
    Abstract: The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: October 9, 2018
    Assignee: The Scripps Research Institute
    Inventors: M. Reza Ghadiri, Luke J. Leman, Yannan Zhao, Bruce E. Maryanoff
  • Uses Of Cyclic Peptides For Treating And Preventing Atherosclerosis Uses of Cyclic Peptides for Treating and Preventing Atherosclerosis
    Publication number: 20160250280
    Abstract: The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.
    Type: Application
    Filed: April 2, 2014
    Publication date: September 1, 2016
    Inventors: M. Reza GHADIRI, Luke J. LEMAN, Yannan ZHAO, Bruce E. MARYANOFF
  • DNA array for high throughput solid-phase transfection and method for producing the same
    Patent number: 6905878
    Abstract: The present invention relates to a DNA array for high throughput and highly efficient solid-based transfection which comprises a plurality of dried spots on a solid support, said dried spot comprises (1) a plasmid DNA to be introduced into cells, (2) a transfection reagent and (3) a cell-adhesion protein and to a high throughput and highly efficient solid-based transfection method to introduce plasmid DNA into cells, using the same.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: June 14, 2005
    Assignee: The Scripps Research Institute
    Inventors: M. Reza Ghadiri, Masato Miyake
  • Porous semiconductor-based optical interferometric sensor
    Patent number: 6897965
    Abstract: The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: May 24, 2005
    Assignees: The Scripps Research Institute, The Regents of the University of California at San Diego
    Inventors: M. Reza Ghadiri, Kianoush Motesharei, Shang-Yi Lin, Michael J. Sailor, Keiki-Pua S. Dancil
  • Porous semiconductor-based optical interferometric sensor
    Publication number: 20040152135
    Abstract: The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
    Type: Application
    Filed: March 16, 2004
    Publication date: August 5, 2004
    Inventors: M. Reza Ghadiri, Kianoush Motesharei, Shang-Yi Lin, Michael J. Sailor, Keiki-Pua S. Dancil
  • DNA array for high throughput solid-phase transfection and method for producing the same
    Publication number: 20040121333
    Abstract: The present invention relates to a DNA array for high throughput and highly efficient solid-based transfection which comprises a plurality of dried spots on a solid support, said dried spot comprises (1) a plasmid DNA to be introduced into cells, (2) a transfection reagent and (3) a cell-adhesion protein and to a high throughput and highly efficient solid-based transfection method to introduce plasmid DNA into cells, using the same.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 24, 2004
    Applicant: The Scripps Research Institute
    Inventors: M. Reza Ghadiri, Masato Miyake
  • Porous semiconductor-based optical interferometric sensor
    Patent number: 6720177
    Abstract: The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: April 13, 2004
    Assignees: The Regents of the University of California, The Scripps Research Institute
    Inventors: M. Reza Ghadiri, Michael J. Sailor, Kianoush Motesharei, Shang-Yi Lin, Keiki-Pua S. Dancil
  • Porous semiconductor-based optical interferometric sensor
    Publication number: 20010044119
    Abstract: The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
    Type: Application
    Filed: February 28, 2001
    Publication date: November 22, 2001
    Inventors: M. Reza Ghadiri, Michael J. Sailor, Kianoush Motesharei, Shang-Yi Lin, Keiki-Pua S. Dancil
  • Porous semiconductor-based optical interferometric sensor
    Patent number: 6248539
    Abstract: The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: June 19, 2001
    Assignees: The Scripps Research Institute, The Regents of the University of California at San Diego
    Inventors: M. Reza Ghadiri, Kianoush Motesharei, Shang-Yi Lin, Michael J. Sailor, Keiki-Pua S. Dancil
  • Method for preparing metallopeptides having stabilized secondary structures
    Patent number: 5410020
    Abstract: The invention contemplates a metallopeptide and a method for producing the metallopeptide. The metallopeptide comprises a polypeptide bonded to a metal cation at two coordinating amino acid residues that are aqueous solvent-accessible, said metallopeptide having a secondary structure stabilized by said bonded metal cation.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: April 25, 1995
    Assignee: The Scripps Research Institute
    Inventor: M. Reza Ghadiri
  • Isolated metallopolypeptide: compositions and synthetic methods
    Patent number: 5408036
    Abstract: This invention contemplates an isolated metallopolypeptide comprising a polyvalent metal ion coordinately linked to 2 to about 8 polypeptide binding ligands, wherein at least 2 of said polypeptide binding ligands are covalently bonded to a linear amphiphilic peptide. The linear amphiphilic peptide has an alpha-helix, beta-sheet or beta-turn conformation. This invention further contemplates a metal ion-assisted, self-assembly method for producing a metallopolypeptide.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: April 18, 1995
    Assignee: The Scripps Research Institute
    Inventor: M. Reza Ghadiri