Patents by Inventor Madhu Hariharan

Madhu Hariharan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10182989
    Abstract: Described herein are pharmaceutical enteric soft capsules that do not contain gelatin as a film-forming polymer. In particular, compositions and methods for manufacturing enteric soft capsules comprising carrageenans as film forming polymers are disclosed.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Qi Fang, Josh Heflin, Madhu Hariharan
  • Publication number: 20180235891
    Abstract: Described herein are pharmaceutical enteric soft capsules that do not contain gelatin as a film-forming polymer. In particular, compositions and methods for manufacturing enteric soft capsules comprising carrageenans as film forming polymers are disclosed.
    Type: Application
    Filed: April 23, 2018
    Publication date: August 23, 2018
    Inventors: Qi FANG, Josh HEFLIN, Madhu HARIHARAN
  • Patent number: 9980916
    Abstract: Enteric soft capsules containing carrageenans as the film-forming polymer have been developed. The enteric soft capsules comprise iota carrageenan and kappa carrageenan, methacrylic acid copolymers, modifeid starch fillers, plasticizers, water, and other excipients. Such enteric soft capsules are stable at pH 1.2 for at least 2 hours and dissolve at pH 6.8 within about 30 minutes. Methods for manufacturing enteric soft capsules comprising carrageenans are also exemplified.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 29, 2018
    Assignee: Patheon Softgels, Inc.
    Inventors: Qi Fang, Josh Heflin, Madhu Hariharan
  • Publication number: 20170348224
    Abstract: A kit for mucosally administering a metastable supersaturated solution of a pharmaceutical active agent to a human patient includes a first compartment comprising a first composition comprising a pharmaceutical active agent in solution at or below equilibrium solubility, and a second composition comprising an acidic buffer. The first and second compartments maintain separation of the first and second compositions during storage, and allow for mixing of the first and second compositions to form a supersaturated solution above equilibrium solubility of the pharmaceutical active agent for immediate mucosal administration to a human patient. In one embodiment, the second composition comprises an acidic buffer and the supersaturated solution has an acidic pH. Alternatively, the second composition comprises a basic buffer and the supersaturated solution has a basic pH.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Inventor: Madhu Hariharan
  • Patent number: 9682039
    Abstract: An oromucosally absorbable liquid composition for administration to a human patient comprises one liquid containing a pH-sensitive pharmaceutically active together with one or more optional suitable pharmaceutical excipients in a first compartment; and a second liquid at pH greater than 5 containing a buffer or alkaline components together with one or more optional suitable pharmaceutical excipients in a second distinct compartment; the first and second compartments maintaining separation of the first and second liquids during storage and allowing for mixing of the two liquids to form an oromucosally absorbable composition at the point of use.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: June 20, 2017
    Assignee: MUCODEL PHARMA LLC
    Inventor: Madhu Hariharan
  • Publication number: 20170151260
    Abstract: A kit for oromucosally administering a metastable supersaturated solution of a pharmaceutical active agent to a human patient includes a first compartment comprising a first composition comprising a pharmaceutical active agent in solution at or below equilibrium solubility, and a second composition comprising an acidic buffer. The first and second compartments maintain separation of the first and second compositions during storage, and allow for mixing of the first and second compositions to form a supersaturated solution above equilibrium solubility of the pharmaceutical active agent for immediate oromucosal administration to a human patient. In one embodiment, the second composition comprises an acidic buffer and the supersaturated solution has an acidic pH. Alternatively, the second composition comprises a basic buffer and the supersaturated solution has a basic pH.
    Type: Application
    Filed: February 10, 2017
    Publication date: June 1, 2017
    Inventor: Madhu Hariharan
  • Publication number: 20160038406
    Abstract: An oromucosally absorbable liquid composition for administration to a human patient comprises one liquid containing a pH-sensitive pharmaceutically active together with one or more optional suitable pharmaceutical excipients in a first compartment; and a second liquid at pH greater than 5 containing a buffer or alkaline components together with one or more optional suitable pharmaceutical excipients in a second distinct compartment; the first and second compartments maintaining separation of the first and second liquids during storage and allowing for mixing of the two liquids to form an oromucosally absorbable composition at the point of use
    Type: Application
    Filed: August 6, 2015
    Publication date: February 11, 2016
    Inventor: Madhu Hariharan
  • Publication number: 20160038425
    Abstract: Described herein are pharmaceutical enteric soft capsules that do not contain gelatin as a film-forming polymer. In particular, compositions and methods for manufacturing enteric soft capsules comprising carrageenans as film forming polymers are disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Qi FANG, Josh HEFLIN, Madhu HARIHARAN
  • Publication number: 20130266520
    Abstract: The present invention relates to rapidly dissolving edible film dosage form incorporating a physical-chemical identifier and/or indicia. The physical-chemical identifier and/or indicia may correspond to an active ingredient that may be evenly distributed throughout the film. The physical-chemical identifier and/or indicia may be associated with at least one section of the film composition and/or associated with a sealed pouch or package containing the film composition and provide information to the consumer, practitioner, producer or regulator that is relevant to the edible film dosage form.
    Type: Application
    Filed: May 27, 2011
    Publication date: October 10, 2013
    Applicant: MONOSOL RX, LLC
    Inventors: Richard C. Fuisz, Madhu Hariharan, Arlie Beuford Bogue, Greg Slominski
  • Publication number: 20120107402
    Abstract: The present invention is directed to a method of analyzing and establishing a proper dosage size in ingestible films for providing a more precise dosage delivery of an active ingredient.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 3, 2012
    Applicant: MONOSOL RX, LLC
    Inventors: Garry Myers, Beuford A. Bogue, Madhu Hariharan
  • Publication number: 20110290694
    Abstract: The present invention relates to rapidly dissolving edible film dosage form incorporating indicia. The indicia may correspond to an active ingredient that may be evenly distributed throughout the film. The indicia may be associated with at least one surface of the film composition and provide information to the consumer that is relevant to the edible film dosage form.
    Type: Application
    Filed: May 27, 2010
    Publication date: December 1, 2011
    Applicant: MONOSOL RX, LLC
    Inventors: Richard C. Fuisz, Madhu Hariharan
  • Publication number: 20110192754
    Abstract: The present invention provides a safe and effective package for housing a dosage, which is easily opened by a user yet provides a secure and contaminant-free environment for the dosage housed within. The package may include a guided tear condition extending along at least one edge of the package, allowing a user to safely and effectively open the package without risk of compromising the dosage housed therein. In some embodiments, the dosage is a substantially flat dosage, such as a film.
    Type: Application
    Filed: February 9, 2010
    Publication date: August 11, 2011
    Applicant: MONOSOL RX, LLC
    Inventors: Greg Slominski, Beuford A. Bogue, Madhu Hariharan, Kurt Easton, Theodore Clemente, JR.
  • Publication number: 20110160264
    Abstract: The invention relates to orally administrable, disintegrating film dosage forms which include ondansetron and methods of orally administering the film dosage forms.
    Type: Application
    Filed: December 27, 2010
    Publication date: June 30, 2011
    Applicant: MONOSOL RX, LLC
    Inventors: Garry L. Myers, Madhu Hariharan
  • Publication number: 20110142942
    Abstract: The present invention relates to an edible film dosage form that includes a film-forming polymer and a coated active composition capable of taste-masking an active contained therein. An edible film that includes an edible, water-soluble film forming polymer and an active with at least two coating layers is also disclosed.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 16, 2011
    Applicant: MONOSOL RX, LLC
    Inventors: A. Mark Schobel, Kevin Davidson, Laura Miloshoff, Pradeep Sanghvi, Madhu Hariharan